1,129 research outputs found
Richard M. Sheirich research collection : materials about Richard Beer-Hofmann 1866-2002
No full textThis collection consists of Richard M. Sheirich’s materials pertaining to his research on Richard Beer-Hofmann’s private correspondence and works. In addition to the original papers, correspondence, notes, and photos of Richard Beer-Hofmann and his family that Richard M. Sheirich gathered, the collection contains Sheirich’s correspondence with Richard Beer-Hofmann’s daughter Miriam Beer-Hofmann Lens, his and other scholars’ works on Beer-Hofmann, several photocopies of the original Beer-Hofmann papers, and Sheirich’s notes.Richard M. Sheirich's book, 'Der Briefwechsel mit Paula 1896-1937’ is available in the LBI Library.Richard M. Sheirich was born on October 9, 1927 in Erie, Pennsylvania. He studied German at Colgate University, Northwestern University and at Universität Hamburg, and earned a Ph. D. in German at Harvard University in 1965; his dissertation was titled “Die Historie von König David.”After teaching German at the University of California at Berkeley, Richard M. Sheirich became a faculty member at Pomona College in 1962 and retired from the same institution in 1996. Sheirich’s research interest was the Austrian literary movement Das Junge Wien and specifically Richard Beer-Hoffman’s work. He started working on Beer-Hofmann’s writings in the 1950s. His work in this field was the preparation of an inventory of the Richard Beer-Hofmann papers for Harvard University. As part of his research, Sheirich travelled to Vienna, Austria several times and conducted a long correspondence with Richard Beer-Hofmann’s daughter Miriam Beer-Hofmann Lens. Alongside other smaller publications, the result of Sheirich’s research was the publication of Der Briefwechsel mit Paula, 1896-1937, Richard Beer-Hofmann’s correspondence with his wife Paula.Richard M. Sheirich died at his home in Claremont on Dec. 11, 2011.Richard Beer-Hofmann was a Viennese author, poet, dramatist and theater director.Processeddigitize
Re-Examination of Cyclized Products from Lycopodine and Clavolonine
No full textTitle: Re-Examination of Cyclized Products from Lycopodine and Clavolonine, Author: Norman M. C. You, Location: ThodeCyclized products derived from lycopodine and clavolonine through
the Hofmann and von Braun reactions were prepared and examined. From
evidence obtained new structures are proposed for the Hofmann products
of lycopodine and clavolonine.ThesisMaster of Science (MS
Author response
No full textTranscription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we discern the functional architecture of human NELF through X-ray crystallography, protein crosslinking, biochemical assays, and RNA crosslinking in cells. We identify a NELF core subcomplex formed by conserved regions in subunits NELF-A and NELF-C, and resolve its crystal structure. The NELF-AC subcomplex binds single-stranded nucleic acids in vitro, and NELF-C associates with RNA in vivo. A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. These results reveal the three-dimensional architecture and three RNA-binding faces of NELF
Protective Immunity against Infection with <i>Mycoplasma haemofelis</i>
No full textHemoplasmas are potentially zoonotic mycoplasmal pathogens, which are not consistently cleared by antibiotic therapy. Mycoplasma haemofelis is the most pathogenic feline hemoplasma species. The aim of this study was to determine how cats previously infected with M. haemofelis that had recovered reacted when rechallenged with M. haemofelis and to characterize the immune response following de novo M. haemofelis infection and rechallenge. Five specific-pathogen-free (SPF)-derived naive cats (group A) and five cats that had recovered from M. haemofelis infection (group B) were inoculated subcutaneously with M. haemofelis. Blood M. haemofelis loads were measured by quantitative PCR (qPCR), antibody response to heat shock protein 70 (DnaK) by enzyme-linked immunosorbent assay (ELISA), blood lymphocyte cell subtypes by flow cytometry, and cytokine mRNA levels by quantitative reverse transcriptase PCR. Group A cats all became infected with high bacterial loads and seroconverted, while group B cats were protected from reinfection, thus providing the unique opportunity to study the immunological parameters associated with this protective immune response against M. haemofelis. First, a strong humoral response to DnaK was only observed in group A, demonstrating that an antibody response to DnaK is not important for protective immunity. Second, proinflammatory cytokine interleukin-6 (IL-6) mRNA levels appeared to increase rapidly postinoculation in group B, indicating a possible role in protective immunity. Third, an increase in IL-12p35 and -p40 mRNA and decrease in the Th2/Th1 ratio observed in group A suggest that a Th1-type response is important in primary infection. This is the first study to demonstrate protective immunity against M. haemofelis reinfection, and it provides important information for potential future hemoplasma vaccine design.</p
Geographical map of Upper Austria.
No full text<p>A detailed analysis of seroprevalences [%] marked in green, yellow, orange and red of all districts is shown. Areas in grey are those with no available data. Copyright: The map of Austria is adapted from Statistik Austria and modified by Niklas N., <a href="http://www.statistik.at/web_de/services/interaktive_karten" target="_blank">http://www.statistik.at/web_de/services/interaktive_karten</a>; The map of Upper Austria is adapted from wikipedia, author AleXXw and modified by Hofmann M., <a href="http://de.wikipedia.org/wiki/Datei:Karte_A_Ooe_ohne.svg" target="_blank">http://de.wikipedia.org/wiki/Datei:Karte_A_Ooe_ohne.svg</a></p
Analysis of interleukin-4 receptor α chain variants in multiple sclerosis
No full textA recent candidate gene study employing microsatellite markers suggested a possible linkage of multiple sclerosis (MS) with the interleukin-4 receptor (IL4R) gene. Consequently, we investigated the association of different IL4R variants with MS in 341 german MS patients and 305 healthy controls. Analysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production. However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS but revealed an increased frequency of the R551 Variant in MS patients with primary progressive MS (PPMS, n=48) as compared to patients with relapsing remitting MS or secondary progressive MS (RR/SPMS n=284; P=0.005 for genotype differences) and to 305 healthy controls (P=0.001 for genotype differences). This association was statistically independent of the presence of the well-known MS susceptibility allele HLA-DRB1 15. After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant. These results indicate, that the IL4R variant R551 may influence the genetic predisposition for PPMS but does not represent a general genetic risk factor for MS. (C) 2001 Elsevier Science B.V. All rights reserved
Syntheses and transformations of multimetallic nanoparticles
No full textMultimetallic nanoparticles have had increased interest in recent years. In this thesis, we analyze Au, Ag, and Cu nanoparticles and multimetallic nanoparticles containing these three coinage metals. The incorporation of two or more metals together within nanoparticles allows for synergistic enhancements in their properties. Specifically, these nanoparticles containing at least two of the metals Au, Ag, or Cu have been studied for their potential in applications including: imaging, catalysis, sensing, and biomedical uses. With further investigation of these applications, transformations of these nanomaterials can have impact on their overall performance. Cu and Ag nanoparticles specifically are prone to oxidation and dissolution. Multimetallic nanoparticles have the potential to replace their monometallic counterparts but further investigation needs to be completed to see how they are affected by these transformations. Au, Ag and Cu multimetallic nanoparticles have been analyzed for oxidation but dissolution studies have not been completed.
In Chapter 1, multimetallic nanoparticles and their properties are introduced. A brief history on the transition of metallurgy from the Bronze Age to the use of multiple metals in nanoparticles is described. The properties of monometallic nanoparticles and the synergistic enhancement that multimetallic nanoparticles display compared to them is outlined. We detail the structures and synthetic strategies for multimetallic nanoparticles. Finally, oxidation and dissolution of Cu nanoparticles are described and the potential for multimetallic nanoparticles to counteract dissolution is hypothesized.
Before nanoparticles could be investigated for their transformation, a reproducible, tunable synthesis for monodisperse, multimetallic nanoparticles must be investigated. In Chapter 2, we develop a novel two-phase synthesis for AuCu and AuAg nanoparticles that is inspired by the Brust synthesis for monodisperse Au nanoparticles. The synthesis takes advantage of complex ions to incorporate greater proportions of Cu into the nanoparticles. Nanoparticles were found to be monodisperse in size and shape. The compositions of the nanoparticles were tunable from 100% Au to 100% Cu. The reproducible synthesis for monodisperse, ultrasmall AuCu nanoparticles allowed for the nanoparticles to be analyzed for their transformations without the results being due to polydisperse sizes, shapes, or compositions.
The transformations of AuCu nanoparticles including oxidation and dissolution are analyzed in Chapter 3. Oxidation of the Cu within the particles was studied using X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and energy electron-loss spectroscopy (EELS). Results found that the particles initially do not display obvious oxidation but some Cu+ may be present in the nanoparticles with higher percentages of Cu. Overtime the particles were found to display more Cu2+ character which can indicate CuO formation. The 1:1 (Au:Cu) composition exhibited increased levels of CuO within the particles compared to the other AuCu compositions and the Cu nanoparticles. The dissolution of the nanoparticles was investigated naturally within purified water and when initiated using cyanide. The dissolution of AuCu in natural waters found that the 1:3 composition displayed the highest levels of Cu ions when compared with the other compositions. The forced dissolution of the particles using cyanide found that Cu nanoparticles had the highest rate of dissolution and Au nanoparticles had the lowest rate. As Cu was added to the Au nanoparticles, the rate of dissolution initially increased but the rate decreased as more Cu was incorporated into the nanoparticles with the 1:3 (Au:Cu) composition having the lowest rate of dissolution. This information details that bimetallic AuCu nanoparticles can lower dissolution of Cu by using specific composition for the suited applications.
Development of synthetic methodology was also applied to anisotropic multimetallic nanoparticles. In Chapter 4, we detail a novel synthesis for AuAgCu “miniature” nanorods. This synthesis was inspired by previous research in the Murphy group for Au “miniature” nanorods. The trimetallic “miniature” nanorods were found to have widths of less than 10 nm and aspect ratios that were tuned by the amount of Cu added to the growth solution. Elemental mapping revealed that Au, Ag, and Cu were found throughout the nanorods to indicate the particles were disordered alloys. Finally, the oxidation state of Ag and Cu were analyzed within the particles using XPS. Results found that there may be evidence of Cu+ and Ag+ within the particles synthesized with the highest amount of Cu in the growth solution.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-05-01The student, Daniel Hofmann, accepted the attached license on 2020-04-23 at 13:05.The student, Daniel Hofmann, submitted this Dissertation for approval on 2020-04-23 at 13:17.This Dissertation was approved for publication on 2020-04-23 at 15:14.DSpace SAF Submission Ingestion Package generated from Vireo submission #15046 on 2020-08-25 at 17:28:04Made available in DSpace on 2020-08-26T23:55:53Z (GMT). No. of bitstreams: 2
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Teleiopsis albifemorella Hofmann 1867
No full text<i>Teleiopsis albifemorella</i> (Hofmann, 1867) <p>(Figs 1–6, 11–14, 19–21, 25–28, 33–35)</p> <p> <i>Gelechia albifemorella</i> Hofmann, 1867: 204.</p> <p> <b>Diagnosis.</b> Species of the <i>Teleiopsis diffinis</i> -group are very similar in phenotypic appearance and in genitalia morphology. <i>T. albifemorella</i> differs from the sibling <i>T. paulheberti</i> <b>sp. nov.</b> in several somewhat weak characters (see below), from <i>T. rosalbella</i> by less contrasting white bands and the absence of a salmon-pink tinge of the forewing and from <i>T. diffinis</i>, <i>T. bagriotella</i>, <i>T. laetitiae</i> and <i>T. lunariella</i> (Walsingham, 1908) by the cream-white ground colour of the forewing. In male genitalia it differs from all other species of the group (except the newly described) by the apically pointed uncus and in female genitalia by a combination of characters such as the entrance and pouch of the antrum (see i.e. Pitkin 1988).</p> <p> <b>Description.</b> Adult (Figs 1–6). Head cream-white; second segment of labial palpus cream-white, brown at base and apex, and tinged brown medially; thorax and tegula mottled cream and light brown, or rarely plain cream. Forewing length 3, 9.2–11.6 mm, Ƥ, 7.8–10.1 mm; forewing ground colour whitish to whitish-cream, with more or less extensive greyish mottling; oblique fascia of raised black scales from basal part of costa to dorsum; three black dots of raised scales edged with ochreous in middle of forewing; further two spots before whitish subapical fascia; apical part greyish with black spots along termen; fringes grey. Hind wing light grey, nacreous.</p> <p>Male genitalia (including pregenital abdomen) (Figs 11–14, 19–21). Eighth tergite with tongue-shaped posterior lobe, distinct lateral brush of strong coremata and a single stiff spine with small apical hook arising from a small lateral protuberance and extending slightly beyond apex of posterior lobe; anterior part of tergite with deep U-shaped emargination, lateral lobes with brush of long coremata; eighth sternite about half length and two times width of medial part of tergite, posterior margin broadly convex, densely covered with coremata, anterior margin with lateral sclerotized ridges connected to tergite. Uncus narrow, gradually tapered to distinct apical tip, extending to about apex of gnathos; gnathos about same width as uncus, apex broadly rounded; tegumen anteriorly widened, with broad pedunculi, separated by sinusoid emargination with medial sclerite; costa needle-shaped, distinctly shorter than sacculus, base of costa about level with sclerotized medial teguminal margin; sacculus basally broad, distal half more or less abruptly narrowing, apical part weakly curved with dentate apex; phallus long and slender, weakly curved, anteriorly fused with broad and long tube connected to anterior edge of vinculum; ductus ejaculatorius with long, sclerotized lamina.</p> <p>Female genitalia (Figs 25–28, 33–35). Apophysis posterior about three times length of apophysis anterior; eighth segment smooth, without pouches or other particular structures; antrum tubular with cylindrical posterior half, about length of eighth segment including apophysis anterior, entrance with elongated sub-rectangular emargination dorsally, anteriorly a small though distinct sclerotized patch, longitudinal sclerotized fold from about one-third to anterior end of antrum; ductus about length of antrum, slender; corpus bursae round; signum variable, pair of serrated-edged lobes of different width separated by broad medial ridge.</p> <p> <b>Bionomics.</b> <i>T. albifemorella</i> is a characteristic species of alpine scree on limestone substrate. The adults are on the wing from late May to early October, but the majority of records dates from June to August. Late records of freshly emerged specimens from October have been found only at low altitudes and indicate a partial second generation. The moths are attracted to artificial light at night. The peculiar habitats of the species are obviously related to the only known larval host-plant, <i>Rumex scutatus</i>, a species of Polygonaceae exclusively restricted to alpine scree, preferably on limestone with sparse vegetation. The larva has been reported to feed from tubes spun between the basal parts of the food-plant and the soil (Burmann 1977). According to this author it hibernates and is fully grown in May or June but considering the prolonged flight period these data may vary from year to year depending on the snow cover and from region to region. The vertical distribution ranges exceptionally from as low as 400 m to about 2300 m.</p> <p> <b>Distribution</b> (Map 1). <i>T. albifemorella</i> is widely distributed in the Eastern Alps (Austria, Germany, Slovenia, Italy) though absent in the Central part of these mountains, an area where limestone as suitable substrate is extremely scattered and rare. Material from the area of Monte Baldo (Italy: Verona) is attributed to this species and not to the south-western form <i>sensu</i> Pitkin (1988). A unique record from the Western Alps (Switzerland: Wallis) (Sauter 1983) is doubtful, whereas specimens from the Jura mountains, examined by P.H. in 1996, most probably belong to nominotypical <i>T. albifemorella</i>. The only published record from the Balkan Peninsula is based on two specimens collected in Montenegro (Huemer & Jakšic 1996).</p> <p> <b>Remarks.</b> <i>Gelechia albifemorella</i> was described from four allegedly male specimens collected between 1863 and 1865 in the northern limestone Alps of Tyrol (Austria) and Bavaria (Germany) (Hofmann 1867). Pitkin (1988) designated a female specimen from Kaisergebirge in north-eastern Tyrol as the lectotype. Though we have not examined the lectotype, the identity of the species is without any doubts and we have been able to study a considerable topotypical series from Tyrol.</p> <p> The description and figures of <i>T. albifemorella</i> in Huemer & Karsholt (1999) partially refer to <i>T. paulheberti</i> <b>sp. nov.</b> Adult figures 50a and 50c in this book depict the new species, whereas figures of the genitalia are correct for <i>T. albifemorella</i>.</p> <p> <b>MAP 1.</b> The distribution of <i>Teleiopsis albifemorella</i> and <i>T. paulheberti</i> <b>sp. nov.</b> in Europe (exclusively based on examined material). Major COI-haplogroups figured with extra symbols.</p>Published as part of <i>Huemer, Peter & Mutanen, Marko, 2012, Taxonomy of spatially disjunct alpine Teleiopsis albifemorella s. lat. (Lepidoptera: Gelechiidae) revealed by molecular data and morphology — how many species are there?, pp. 1-23 in Zootaxa 3580</i> on pages 6-8, DOI: <a href="http://zenodo.org/record/283033">10.5281/zenodo.283033</a>
Gravitational waves from precessing GRBs
No full textIn the framework of a transient accretion disk at the core of a gamma-ray burst we compute possible periods of Lense-Thirring precession. Next, we evaluate the putative gravitational waves associated with such dynamical setup. Assuming a characteristic time-profile for the gamma-ray emission of a disk-jet system, we obtain light-curves presenting a time microstructure similar to that reported in some GRB events. After adjustment of the parameters out of two specific GRBs we evaluate the detectability of the gravitational waves produced by the precession of this accretion disk. As a conclusion, our analysis shows that some GRBs are likely to be probed with Advanced LIGO.Fil: Romero, Gustavo Esteban. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Reynoso, Matias Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Físicas de Mar del Plata. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Físicas de Mar del Plata; ArgentinaFil: Christiansen, Hugo R.. Universidade Estadual Vale do Acara,; Brasil25th Texas Symposium on Relativistic AstrophysicsHeidelbergAlemaniaMax-Planck-Institut für Kernphysi
Gamma-ray flares from black hole coronae
No full textWe present results of a study of non-thermal, time-dependent particle injection in a corona around an accreting black hole. We model the spectral energy distribution of high-energy flares in this scenario. We consider particle interactions with magnetic, photon and matter fields in the black hole magnetosphere. Transport equations are solved for all species of particles and the electromagnetic output is predicted. Photon annihilation is taken into account for the case of systems with early-type donor stars.Fil: Vieyro, Florencia Laura. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Romero, Gustavo Esteban. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina25th Texas Symposium on Relativistic AstrophysicsHeidelbergAlemaniaMax-Planck-Institut für Kernphysi
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