1,271 research outputs found
Christopher Merrett’s Pinax rerum naturalium britannicarum (1666): annotations to what is believed to be the author’s personal copy.
No full textIn 1666 Christopher Merrett published Pinax rerum naturalium britannicarum, this essentially being a catalogue of British plant localities known at the time together with a few other items of natural history. What is thought to be the author's personal annotated copy is held in the British Library. These annotations have been examined and the hand-writing compared to surviving examples known to be either of the author or of one of his sons and are now transcribed. Brief biographical notes relating to Merrett and to the background to his production of the Pinax are also given
Supplemental_Material_Covalent_BTK_by_Harris,_et_al – Supplemental material for Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase
No full textSupplemental material, Supplemental_Material_Covalent_BTK_by_Harris,_et_al for Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase by Christopher M. Harris, Sage E. Foley, Eric R. Goedken, Mark Michalak, Sara Murdock and Noel S. Wilson in SLAS Discovery</p
The digital divide in a world city
No full textFoley lead author.
Commisioned by Greater London Authority, LondonConnects and the London Development agency.http://static.london.gov.uk/gla/publications/e-london/digital_divide.pd
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
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No full textEsse trabalho discute o foley brasileiro através da apresentação de aspectos técnicos, estéticos e históricos dessa atividade. A partir de entrevistas com profissionais da área e da experiência profissional da autora em foley, é traçado um panorama da atividade que compreende: os usos do foley na trilha sonora cinematográfica; técnicas de gravação; o desenvolvimento da atividade no país dos anos 1950 até hoje; e a observação dos estúdios e artistas de foley brasileiros mais proeminentes em atividade.The present work discusses the Brazilian foley by presenting technical, aesthetic and historical aspects of the activity. Through interviews with foley professionals and the professional expertise of the author, this overview of Brazilian foley comprehends: the use of foley in the film soundtrack, recording techniques, the development of the activity in Brasil since the 1950´s, and the observation of the most prominent foley studios and foley artists in Brazil at the present
Supplemental Material, DS1_VET_10.1177_0300985818758469 - Apical Elongation of Molar Teeth in Captive <i>Microtus</i> Voles
No full textSupplemental Material, DS1_VET_10.1177_0300985818758469 for Apical Elongation of Molar Teeth in Captive Microtus Voles by Denise M. Imai, Risa Pesapane, Christopher J. Conroy, Christina N. Alarcón, Nora Allan, Russell A. Okino, Jennifer Fung, Brian G. Murphy, Frank J. M. Verstraete, and Janet E. Foley in Veterinary Pathology</p
A Quantitative Study of Robustness Characteristics in Steel Framed Structures
No full textRobustness is a desirable property in any structural design. Robustness may be thought of as the building\u27s inherent structural ability to resist loads other than those anticipated during design. Examples of unanticipated loads are damage to a column or beam due to impact; damage due to the concussion of a blast; strength reduction due to extreme heat during a fire; and localized accidental overload of a beam or column. Each of these events, although very different in their nature, has one major point in common; in each case the path of load resistance changes in a way that was not and perhaps could not be anticipated during the original design.
A three-story, pre-Northridge Boston building was chosen as the basis for this study. Although the building is generic, it is representative of typical office buildings constructed in non-seismic areas of the Central and Eastern United States.
The building was modeled using structural engineering software capable of performing a second-order, inelastic analysis with user defined connection characteristics. Ten connection models with varying parameters were considered for evaluation and comparison of their capabilities to withstand loading after a column has been rendered ineffective. The varied parameters include connection placement; bolt quantity; inclusion or exclusion of a seat angle; inclusion or exclusion of the tensile capacity of a reinforced composite floor slab; and depth of concrete in the composite floor slab. Both two-dimensional and three-dimensional frameworks are evaluated.
A robustness measure was defined as the relative change in applied load ratio compared to the applied load ratio of a base system. The base system was identified as one that would be the result of a design considering efficiency in strength and serviceability to withstand code required load combinations.
Models that include both a seat angle and tensile capacity of slab reinforcement produced the most robust system. Adding one additional bolt produced only modest improvement in robustness. Adding depth of concrete was counterproductive due to increased weight. A three-dimensional analysis is very important to adequately quantify robustness in a particular framework. The opposing girders and beams along the gridlines, along with the infill framing, work together to resist unanticipated loading and their total contributions are significant
Connecting people: Tackling exclusion? An examination of the impact on and use of the internet by socially excluded groups in London
No full textFoley lead author.
Foreword by Ken Livingstone, Mayor of London and response by Clive Ansell, Director BT, London.
Commisioned by: Greater London Authority, London Development Agency, LondonConnects and BThttp://static.london.gov.uk/gla/publications/e-london/connecting-commties.pd
Symptoms as a predictor of the placebo-controlled efficacy of PCI in stable coronary artery disease
No full textBackground: placebo-controlled evidence from ORBITA-2 (Objective Randomised Blinded Investigation with Optimal Medical Therapy of Angioplasty in Stable Angina-2) found that percutaneous coronary intervention (PCI) in stable coronary artery disease with little or no antianginal medication relieved angina, but residual symptoms persisted in many patients. The reason for this was unclear.Objectives: this ORBITA-2 secondary analysis investigates the relationship between presenting symptoms and disease severity (anatomic, noninvasive, and invasive ischemia) and the ability of symptoms to predict the placebo-controlled efficacy of PCI.Methods: prerandomization symptom severity and nature were assessed using the ORBITA smartphone application and symptom and quality of life questionnaires including the World Health Organization Rose angina questionnaire (Rose). Disease severity was assessed using quantitative coronary angiography, stress echocardiography, fractional flow reserve, and instantaneous wave-free ratio. Bayesian ordinal regression was used.Results: at prerandomization, the median number of daily angina episodes was 0.8 (Q1-Q3: 0.4-1.6), 64% had Rose angina, quantitative coronary angiography diameter stenosis was 61% (Q1-Q3: 49%-74%), stress echocardiography score was 1.0 (Q1-Q3: 0.0-2.7), fractional flow reserve was 0.63 (Q1-Q3: 0.49–0.75), and instantaneous wave-free ratio was 0.78 (Q1-Q3: 0.55-0.87). There was little relationship between symptom severity and nature and disease severity: angina symptom score with quantitative coronary angiography ordinal correlation coefficient: 0.06 (95% credible interval [CrI]: 0.00-0.08); stress echocardiography: 0.09 (95% CrI: 0.02-0.10); fractional flow reserve: 0.04 (95% CrI: −0.03 to 0.07); and instantaneous wave-free ratio: 0.04 (95% CrI: −0.01 to 0.07). However, Rose angina and guideline-based typical angina were strong predictors of placebo-controlled PCI efficacy (angina symptom score: OR: 1.9; 95% CrI: 1.6-2.1; probability of interaction [PrInteraction] = 99.9%; and OR: 1.8; 95% CrI: 1.6-2.1; PrInteraction = 99.9%, respectively).Conclusions: although symptom severity and nature were poorly associated with disease severity, the nature of symptoms powerfully predicted the placebo-controlled efficacy of PCI.<br/
Ischemia on dobutamine stress echocardiography predicts efficacy of PCI: results from the ORBITA-2 trial
No full textBackground: ORBITA-2 (The Placebo-Controlled Trial of Percutaneous Coronary Intervention for the Relief of Stable Angina) found that percutaneous coronary intervention (PCI) relieved angina in patients with single-vessel and multivessel stable coronary artery disease (CAD) on little or no antianginal medication. Whereas symptom characteristics and invasive physiological assessments can predict PCI efficacy, the role of noninvasive imaging with dobutamine stress echocardiography (DSE) remains unclear.Objectives: this DSE-stratified secondary analysis of ORBITA-2 investigates the relationship between ischemia, assessed by DSE, and the placebo-controlled efficacy of PCI.Methods: participants with angina, single-vessel or multivessel CAD, and ischemia were enrolled. Following discontinuation of antianginal medications, patients were evaluated prerandomization using the ORBITA-app, questionnaires, DSE, and exercise treadmill testing. Stress echocardiography scores were calculated for each left ventricular segment at peak stress, with normal, hypokinetic, akinetic, dyskinetic, and aneurysmal segments scoring 0 to 4, respectively. Bayesian proportional odds modeling was used.Results: prerandomization DSE data were available for 262 patients. The median age was 65.5 years (Q1-Q3: 59-71 years), and 208 (79.4%) were male. At baseline, the median stress echocardiography score was 1.42 in the PCI group (n = 133) and 1.00 in the placebo group (n = 129), with an overall median score of 1.25 (Q1-Q3: 0.33-2.92). Higher stress echocardiography scores were strongly associated with greater placebo-controlled improvements in angina symptom score following PCI (OR: 1.23; 95% credible interval [CrI]: 1.13-1.35; Pr(interaction) > 99.9%). Higher scores also predicted significant reduction in daily angina episodes (OR: 1.36; 95% CrI: 1.24-1.49; Pr(interaction) > 99.9%), as well as improvement in the Seattle Angina Questionnaire angina frequency score (8.22; 95% CrI: 0.96-15.50; Pr(interaction) = 98.7%), and Seattle Angina Questionnaire quality of life score (8.95; 95% CrI: 2.05-16.00; Pr(interaction) = 99.3%). The relationship between stress echocardiography score and reduction in daily angina episodes remained consistent, irrespective of symptom characteristics.Conclusions: in patients with single- and multivessel stable CAD on little or no antianginal medication, the placebo-controlled efficacy of PCI was predicted by the degree of ischemia detected on DSE. The greater the burden of baseline ischemia, the greater the improvement in symptoms and quality of life with PCI
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