3,879 research outputs found
Bull, Christopher
No full textMemorial Statement for Professor Christopher Bull who died in 2002. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
Prediction of the binding free energies of inhibitors of epidermal growth factor receptor kinase and the identification of the dynamics thereof
No full textEpidermal Growth Factor Receptor (EGFR) kinase is a signalling protein implicated in a number of cancers, including non-small cell lung cancer (NSCLC). As well as activating mutations of EGFR kinase being oncogenic, the prognosis of NSCLC correlates with the impact of EGFR mutations on inhibitor binding affinities. However, treatment with tyrosine kinase inhibitors is particularly vulnerable to resistance mutations. The exact mechanisms by which EGFR kinase mutations impart activation or resistance has not been clearly defined at an atomistic level, and attempts to elucidate these mechanisms in silico are hindered by the long time scales over which the conformational dynamics of EGFR kinase occur. In this thesis rigorous free energy calculations are employed to investigate the relative binding free energy of inhibitors of EGFR kinase, and elucidate the hydration of the binding pocket. Additionally, various enhanced molecular dynamics (MD) sampling methods are utilised alongside conventional MD to investigate their ability to overcome the challenge of the long time scales of conformational change in EGFR kinase. The complementary use of dimensionality reduction techniques such as principal components analysis and locally scaled diffusion map analysis is shown to be useful in characterising long time scale dynamics, as well as in validating the sampling of enhanced MD methods. Using these techniques alongside traditional analyses, new insight into the role of three activating mutations was gained; however, the results suggest that accessible simulation times are still too short, implying a continuing role for enhanced MD methods in the future
Oral History Interview: Peter Bull
No full textThis interview is one of series conducted concerning the Oral History of Appalachia. Peter Bull was an English actor and author. He discusses: Greece; books he has written; long and detailed discussions of teddy bears; his family; people he has known; astrology; his career in theater; movies he has starred in; other movies and plays; his pet dogs; and other topics.https://mds.marshall.edu/oral_history/1566/thumbnail.jp
AME025 configuration
No full text<p>The AME025 is based on the WED025_NEMO_chrisbull.tar.gz created by Christopher Bull. More details can be found at https://zenodo.org/record/3767939.</p>
GP benchmark: Engineering a crowd-sourcing platform for real-time understanding of personality and cognitive biases in clinical error
No full textErrors in medicine are a significant problem, highlighted as a global safety priority. General Practice is one clinical arena where error is more likely due to clinical decisions being made on a background of clinical complexity, undifferentiated symptoms and diseases, and multiple other factors as yet unquantified. Interventions designed to reduce error are either underutilised, untested, fail to produce lasting results, are designed on inadequate knowledge, or have failed to appreciate the interaction of multiple factors, both cognitive and systemic. We present a potential solution, in the form of GP Benchmark. GP Benchmark is an online simulation environment and tool designed to test clinical decision making in a group of practicing General Practitioners. Its aim is to address two pressing requirements: 1) the need to capture clinical decision making in real-time, in the context of personality, cognitive bias and environmental factors, and 2) the need to provide a validated platform that models the clinical environment so future intervention decisions may be tested without risking patient safety. We highlight the requirements satisfied for implementing GP Benchmark, the plans for validation, and discuss how GP Benchmark will be used to identify further requirements necessary to develop the environment into a tool for testing clinical decision support systems and error prevention strategies
Christopher Bull Politics in Packaged Software Implementation Politics in Packaged Software Implementation
No full textThe academic literature relating to the political issues of information systems is fairly well established. However, there are relatively few empirical studies relating to the political issues associated with the organisational implementation of package software. The aim of this paper is to offer a modest contribution via case study research with an analysis of a packaged software implementation at an organisation based in the United Kingdom. The study raises issues that support and question some of the notions inherent in many political theories relating to information systems. The study also highlights the multifarious and complex nature of politics in the development of packaged software implementation
Real-time through-thickness and in-plane strain measurement in carbon fibre reinforced polymer composites using planar optical Bragg gratings
No full textA new strain sensor is proposed which can measure both through-thickness and in-plane strains within a laminated fibre-reinforced composite material. The planar sensor uses novel embedded planar optic sensors and is demonstrated on a carbon fibre composite test coupon. The planar optical sensor was fabricated via flame hydrolysis deposition and was physically machined to reduce the substrate thickness to <50µm. Strain components are decoupled through monitoring the transverse electric and transverse magnetic effective refractive indices of two orthogonal planar waveguides. The work investigates if the embedded planar sensors have any mechanical knock down effects on the composite structure and demonstrates their effectiveness at decoupling three orthogonal strain components
What Happens in Peer-Support, Stays in Peer-Support: Software Architecture for Peer-Sourcing in Mental Health
No full textDigital health technology utilizing wearables, IoT and mobile devices has been successfully applied in the monitoring of numerous diseases and conditions. However, intervention, in response to monitored data, is yet to benefit from technological support and continues to follow a traditional point-of-care delivery model by providers and health professionals. Mental health is an example of a critical health area in dire need for technology solutions to enable timely, effective and scalable interventions. This is especially the case with an increasing prevalence of mental health conditions and a declining capacity of the healthcare professional workforce. Numerous studies reveal the potential for peer support groups as an effective, scalable, cost-effective, first-line of response in mental health interventions. Peer support helps participants, at low and moderate risk, better understand their diseases or conditions and empowers them to take control of their own health. Peer support interactions also seems to inform health professionals with insights and intricate knowledge, making it effectively a learning health system. This paper proposes a software architecture to better enable "peer-sourcing". We present related work and show how the proposed architecture might draw similarity to and differences from crowd-sourcing architectures. We also present a study in which we interacted with service users (mental health patients) and mental healthcare professionals to better understand and elicit the key requirements for the software architecture
Ear's cutting of American Pitt Bull terriers and Staffordshire bull terriers
No full textL’auteur, devant le nombre d’essorillages demandé sur les Pit Bull Terriers américains et les Staffordshire Bull Terriers, a codifié une technique de chirurgie esthétique.In front of the number of request for ears’s cutting of american Pit Bull Terriers and Staffordshire Bull Terriers, the author gives the rules of this plastic surgery
Papal bull granting Spain possession of lands discovered by Columbus
No full textA broadside, titled in Spanish, containing a copy of the Latin text of the bull, Inter cetera, of May 4, 1493 of Pope Alexander VI, granting Spain possession of lands discovered by Christopher Columbus
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