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Dopaminergic sensitivity in the prefrontal cortex is associated with variations in general cognitive abilities and is a target for working memory training
No full textAn individual’s performance across diverse tests of cognitive ability tends to co-vary, indicative of a common source of underlying variance (i.e., "general intelligence"). Recent evidence indicates that the processing efficacy of working memory predicts the level of general intelligence in humans and general cognitive abilities (GCA) in non-human animals (e.g. rodents and monkeys). One component of working memory, namely selective attention, has been reported to highly co-vary with general intelligence, and evidence suggests that dopamine D1 signaling in the medial prefrontal cortex (mPFC) critically modulates attentional abilities. Here, we characterized the GCA of 48 CD-1 outbred mice based on their aggregate performance across five diverse tests of learning. Using immunohistochemical techniques following administration of a D1 agonist (SKF82958, 1 mg/kg), we examined the relationship between GCA and endogenous sensitivity of D1 receptors in the mPFC, the dlPFC, and the striatum. Results indicate a differential sensitivity of D1 receptors in the mPFC (but not the dlPFC or striatum) between animals of high GCA and low GCA (quantified by cFos activation in response to the D1 agonist). In Experiment 2, we assessed whether the enhancement in D1 receptor sensitivity levels were the result of an increased amount of D1 receptors in the mPFC. Results indicated that animals of high GCA and low GCA express no differences in the density of D1 receptors in the mPFC. Subsequently we examined whether the imposition of a working memory training regimen (with a high demand on selective attention) modulates the same dopaminergic signaling mechanisms that were associated with innate GCA. Working memory training promoted an increase in animals’ GCA and enhanced the sensitivity of D1 receptors in the mPFC. These findings suggest that the sensitivity (but not number) of D1 receptors in the mPFC may both regulate GCA and may be a target for working memory training that promotes GCA.M.S.Includes bibliographical referencesby Christopher David Was
Christopher David Macfarlane grave marker, Ephraim, Utah, 1999 (2 of 5)
No full textChristopher David Macfarlane grave marker, Ephraim Park Cemetery in Ephraim, Utah (651 North Main Street) shows an oval headstone with a color photo of a young boy. In the bottom right corner there is an engraved image of a teddy bear on a gurney hooked up to an IV
Christopher David Lee
No full textChristopher David Lee was born and raised in Bedford, Indiana. He graduated from that city’s Bedford North Lawrence High School in 1985, before enrolling at DePauw University in Greencastle, Indiana. A member of the DePauw varsity football and track teams, Lee was elected Student Body President during his senior year. He graduated from DePauw with a B. A. in Political Science in 1989. Later that year he enrolled at the Indiana University School of Law. Lee received his JD degree from the law school in 1993.
Chris Lee has spent his entire legal career in Southern Indiana. He rose to become a partner at the Evansville firm of Kahn, Dees, Donovan & Kahn, and is currently partner at Wooden McLaughlin. Lee has a broad based civil litigation practice, frequently managing complex litigation involving multiple attorneys and parties. He is a frequent speaker on trial practice and advocacy issues.
As a member of the Indiana National Guard, Lee was deployed to Bosnia in 2001 and Afghanistan in 2004. While in Afghanistan he founded the Afghanistan Relief Fund, which supports three orphanages, three hospitals, several refute camps, and a school. Lee was awarded the Army Bronze Star for his service in Afghanistan. Lee is a recipient of the Evansville Bar Association\u27s James Bethel Gresham Freedom Award, the Raymond L. White Award for Distinguished Military Service, and is one of the youngest attorneys to have been named an Indiana Super Lawyer. Additionally, Christopher D. Lee received a 2014 Indiana University Maurer School of Law Distinguished Service Award.https://www.repository.law.indiana.edu/notablealumni/1220/thumbnail.jp
Christopher David Lee
No full textChristopher David Lee was born and raised in Bedford, Indiana. He graduated from that city’s Bedford North Lawrence High School in 1985, before enrolling at DePauw University in Greencastle, Indiana. A member of the DePauw varsity football and track teams, Lee was elected Student Body President during his senior year. He graduated from DePauw with a B. A. in Political Science in 1989. Later that year he enrolled at the Indiana University School of Law. Lee received his JD degree from the law school in 1993.
Chris Lee has spent his entire legal career in Southern Indiana. He rose to become a partner at the Evansville firm of Kahn, Dees, Donovan & Kahn, and is currently partner at Wooden McLaughlin. Lee has a broad based civil litigation practice, frequently managing complex litigation involving multiple attorneys and parties. He is a frequent speaker on trial practice and advocacy issues.
As a member of the Indiana National Guard, Lee was deployed to Bosnia in 2001 and Afghanistan in 2004. While in Afghanistan he founded the Afghanistan Relief Fund, which supports three orphanages, three hospitals, several refute camps, and a school. Lee was awarded the Army Bronze Star for his service in Afghanistan. Lee is a recipient of the Evansville Bar Association\u27s James Bethel Gresham Freedom Award, the Raymond L. White Award for Distinguished Military Service, and is one of the youngest attorneys to have been named an Indiana Super Lawyer. Additionally, Christopher D. Lee received a 2014 Indiana University Maurer School of Law Distinguished Service Award.https://www.repository.law.indiana.edu/notablealumni/1220/thumbnail.jp
Christopher David Macfarlane grave marker, Ephraim, Utah, 1999 (5 of 5)
No full textChristopher David Macfarlane grave marker, Ephraim Park Cemetery in Ephraim, Utah (651 North Main Street) shows the backside of a headstone engraved with mountains and a sun in the background. There is a Y on the mountain side representing Brigham Young University (BYU). Evergreen trees can be seen on each side of the river. There is a tent on the left hand side of the image
Christopher David Macfarlane grave marker, Ephraim, Utah, 1999 (1 of 5)
No full textChristopher David Macfarlane grave marker, Ephraim Park Cemetery in Ephraim, Utah (651 North Main Street) shows the backside of a headstone engraved with mountains and a sun in the background. There is a Y on the mountain side representing Brigham Young University (BYU). Evergreen trees can be seen on each side of the river. There is a tent on the left hand side of the image
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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