55,483 research outputs found
Overexpression of Cyclin D1 and C-Myc Gene Products in Human Primary Epithelial Ovarian Cancer
No full textCyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. To date, data on the relationship of expression of these proteins and histologic subtype of epithelial ovarian cancer are still scarce and discordant. Immunohistochemical analysis was performed on 12 normal ovaries and 47 cases of serous, mucinous, endometrioid, and clear cell ovarian carcinomas. No abnormal expression of cyclin D1 or c-Myc was demonstrated in any of the 12 normal ovarian specimens. However, compared to normal ovarian tissues, overexpression of cyclin D1 and c-Myc was observed in 42.6% (20/47) and 65.9% (31/47) of tumors examined, respectively. There was no significant difference of overexpression of cyclin D1 or c-Myc gene products between these four histologic subtypes of ovarian adenocarcinomas. This study shows that cyclin D1 and c-Myc are frequently overexpressed in epithelial ovarian carcinomas, but they are not correlated with a particular histologic subtype. Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D 1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis and deserve further study
Time course of Ca2+ concentration triggering exocytosis in neuroendocrine cells.
No full textWe have used the secretory response of chromaffin cells to estimate the submembrane intracellular Ca2+ concentration ([Ca2+]i) "seen" by secretory granules during short depolarizations. The rate of secretion during a depolarization was assessed by combining the electrochemical method of amperometry and electrical capacitance measurements. The rate was then related to [Ca2+]i based on a previous characterization of how Ca2+ affects the dynamics of vesicle priming and fusion in chromaffin cells [Heinemann, C., Chow, R. H., Neher, E. & Zucker, R. S. (1994) Biophys. J. 67, in press]. Calculated [Ca2+]i rose during the depolarization to a peak of < 10 microM, then decayed over tens of milliseconds. In synapses, vesicles are presumed to be located within nanometers of Ca2+ channels where [Ca2+]i is believed to rise in only microseconds to near steady-state levels of hundreds of micromolar. Channel closure should lead to a decrease in [Ca2+]i also in microseconds. Our findings of the slower time course and the lower peak [Ca2+]i suggest that in chromaffin cells, unlike synapses, Ca2+ channels and vesicles are not strictly colocalized. This idea is consistent with previously published data on dense-core vesicle secretion from diverse cell types
Important Lessons from Studying the Chinese Economy
Full text linkIn 1979 the United States and China established normal diplomatic relations, allowing me to visit China and study the Chinese economy. After doing so for thirty years since and advising the government of Taiwan in the 1960s and the 1970s and the government of the People’s Republic of China in the 1980s and the 1990s this is an opportune moment for me to summarize the important lessons that I have learned. The lessons will be summarized in four parts: on economic science, on formulating economic policy and providing economic advice, on the special characteristics of the Chinese economy and on the experience of China’s economic reform. At the beginning I should comment on the quality of Chinese official data on which almost all quantitative studies referred to in this article were based. Chow (2006(a)) has presented the view that by and large the official data are useful and fairly accurate. The main justification is that every time I tested an economic hypothesis or estimated an economic relation using the official data the result confirmed the well-established economic theory. It would be a miracle if I had the power to make the Chinese official statisticians fabricate data to support my hypotheses. Even if I had had the power, most of the data had already been published for years before I conceived the ideas of the studies reported in this article.China, Chinese economy, Taiwan, economic reforms, data
Letter from C. H. Gensler, Havasupai Agency to Carl Hayden
No full textLetter from C. H. Gensler expressing concern on behalf of the Havasupai Tribe regarding the proposed park boundaries
Citations of the author H C Rajpoot
No full textThe list of the articles, research papers, theses, and book chapters globally citing the author H. C. Rajpoot</p
Letter from Carl Hayden to C. H. Gensler
No full textLetter from Carl Hayden to C. H. Gensler informing him of the proposed Grand Canyon National Park bill
Application of H-titanate nanofibers for degradation of Congo Red in an annular slurry photoreactor
No full textAnatase nanofibers (TiO2-N) were synthesized as photocatalyst for the application in an annular slurry photoreactor (ASP). The unique properties of TiO2-N have facilitated its high reactivity and suitability for water treatment. The influence of operational variables: TiO2-N loading, pH, aeration rate and dye concentration on the photo-degradation kinetics and efficiency to remove a model compound of Congo Red (CR) were investigated. The photo-degradation kinetics of CR followed the Langmuir-Hinshelwood regime at lower pH. The Langmuir adsorption constant, KL-H was determined as 7.695×102 dm3 mol−1. The optimal photo-degradation rate of 3.47×10−2 moldm−3 min−1 was achieved at 60ppm CR, pH 3, aeration rate of 5 dm3 min−1 and TiO2-N loading of 4 g dm−3. Batch settling tests based on Kynch's theory revealed that the TiO2-N photocatalysts could produce a settling velocity of 8.38×10−4 ms−1. It was expected that these novel TiO2-N particles can deliver a true engineering solution as an industrial process for photocatalytic water treatment.Meng Nan Chong, Bo Jin, H.Y. Zhu, C.W.K. Chow and Chris Sain
Letter from C. H. Gensler, Havasupai Agency to Carl Hayden
No full textLetter from C. H. Gensler to Carl Hayden asking for a meeting in regards to the Havasupai pasture land in light of the national park bill
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