1,720,994 research outputs found
ACCURATE 3D CUTTING FORCE PREDICTION USING CUTTING-CONDITION-INDEPENDENT COEFFICIENTS IN BALL-END MILLING
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Journal of Manufacturing Science and Engineering, Transactons of the ASME: Preface
No full textarchiving status unknown11scopu
Application of Gelatin Bioinks and Cell-Printing Technology to Enhance Cell Delivery Capability for 3D Liver Fibrosis-on-a-Chip Development
No full textLiver fibrosis is a critical liver disease which can lead to liver cirrhosis, cancer, and liver failure. Among various etiological factors, activated stellate cells are a major factor that can induce liver fibrosis. Several studies have presented in vitro models to identify drugs for liver fibrosis; however, there are still limitations in terms of the 2D culture conditions, random co-culture of liver cells, and lack of extracellular matrix components. Therefore, a 3D liver fibrosis-on-a-chip was developed with three liver cell types (hepatocytes, activated stellate cells, and endothelial cells) using a novel cell-printing technique with gelatin bioinks, which were used to deliver each nonparenchymal liver cell type as a multilayer construct. Liver fibrosis-specific gene expression, collagen accumulation, cell apoptosis, and reduced liver functions caused by activated stellate cells were also evaluated. Furthermore, previously reported chemicals were added to the 3D liver fibrosis-on-a-chip to examine the downregulation of activated hepatic stellate cells. In conclusion, the developed 3D liver fibrosis-on-a-chip could be used as a potential in vitro model in the research field.11Nsciescopu
Bioprinting of 3D Tissue Models Using Decellularized Extracellular Matrix Bioink
No full textBioprinting provides an exciting opportunity to print and pattern all the components that make up a tissue—cells and extracellular matrix (ECM) material—in three dimensions (3D) to generate tissue analogues. A large number of materials have been used for making bioinks; however, majority of them cannot represent the complexity of natural ECM and thus are unable to reconstitute the intrinsic cellular morphologies and functions. We present here a method for making of bioink from decellularized extracellular matrices (dECMs) and a protocol for bioprinting of cell-laden constructs with this novel bioink. The dECM bioink is capable of providing an optimized microenvironment that is conducive to the growth of 3D structured tissue. We have prepared bioinks from different tissues, including adipose, cartilage and heart tissues and achieved high cell viability and functionality of the bioprinted tissue structures using our novel bioink
3D printing of cell-laden constructs for heterogeneous tissue regeneration
No full textThree-dimensional (3D) printing of relevant components of tissue, such as cells and matrix material, has been used for fabrication of tissue analogs. However, fabrication using existing cell printing systems is difficult for printing of tissues with complex shapes and compositions. In this study, we successfully printed 3D cell-laden constructs using the principle of hybrid structure fabrication. A sacrificial layer process, in combination with current 3D printing technology, was used to fabricate complex shaped tissues. We demonstrated practicality of using 3D printing to fabricate cell-laden constructs, where cells were localized as intended. The cell viability of the fabricated constructs was high.1129scopu
Rapid prototyping technology for bone regeneration
No full textBone is a dynamic, highly vascularized tissue with a unique capacity to heal and remodel without scarring. Tissue engineering (TE) offers a promising new approach for bone repair, and the development of scaffolds used to restore damaged bone tissue is increasingly used in bone TE. Various methods for manufacturing scaffolds to replace bone tissue have been developed. However, scaffolds developed using conventional fabrication techniques have severe disadvantages in precision and reproducibility. To overcome these, tissue engineers have devised strategies, such as solid free-form (SFF) fabrication techniques, to fabricate porous, fully interconnected scaffolds for bone TE applications. In addition, cell-printing technology has been used to manufacture cell-laden bone regeneration constructs. This chapter reviews RP-based three-dimensional bone-graft analogues fabricated using state-of-the-art computer-assisted tissue-fabrication strategies for bone TE. © 2020 Elsevier Ltd. All rights reserved.11Nscopu
Erratum to: Development and analysis of three-dimensional (3D) printed biomimetic ceramic (International Journal of Precision Engineering and Manufacturing, (2016), 17, 12, (1711-1719), 10.1007/s12541-016-0198-2)
No full textThe title of the above article should be corrected as follows: Development and Analysis of Three-Dimensional (3D) Printed Biomimetic Ceramic Ossicles. ? 2017, Korean Society for Precision Engineering and Springer-Verlag Berlin Heidelberg.1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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