1,721,254 research outputs found
A new scale for prognostication in Parkinson disease: Of animals and men
No full textPrognosis has always represented one the main goals of medicine. For example, stroke prognosis was discussed by Ibn Sina (Avicenna) in his Canon of Medicine published in 1025. 1 Not too far off from our current concepts, Ibn Sina stated that stroke prognostic factors were respiratory status and impairment of the swallowing reflex. In modern medicine, oncology is the area in which the determination of prognostic factors has reached the highest reliability, with development of the first version of TNM staging by Pierre Denoix during the 1940s. 2 The awareness of the necessity to develop prognostic rating scales in the area of neurodegenerative disorders is more recent, probably driven by the increasing range of available therapies and therapeutic trials. However, it is largely recognized that attaining a reliable outcome prediction in neurodegenerative disorders is complex, due to their clinical and pathogenic heterogeneity
Prevalence of Parkinson's disease in Northwestern Italy: Comparison of tracer methodology and clinical ascertainment of cases
No full textGOMPERTZIAN ANALYSIS OF AMYOTROPHIC-LATERAL-SCLEROSIS MORTALITY IN ITALY, 1957-1987 - APPLICATION TO BIRTH COHORTS
No full textGlobal epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The NGS technology for the identification of genes associated with the ALS. A systematic review
Full text linkBackground: More than 30 causative genes have been identified in familial and sporadic amyotrophic lateral sclerosis (ALS). The next-generation sequencing (NGS) is a powerful and groundbreaking tool to identify disease-associated variants. Despite documented advantages of NGS, its diagnostic reliability needs to be addressed in order to use this technology for specific routine diagnosis. Material and Methods: Literature database was explored to identify studies comparing NGS and Sanger sequencing for the detection of variants causing ALS. We collected data about patients’ characteristics, disease type and duration, NGS and Sanger properties. Results: More than 200 bibliographic references were identified, of which only 14 studies matching our inclusion criteria. Only 2 out of 14 studies compared results of NGS analysis with the Sanger sequencing. Twelve studies screened causative genes associated to ALS using NGS technologies and confirmed the identified variants with Sanger sequencing. Overall, data about more 2,000 patients were analysed. The number of genes that were investigated in each study ranged from 1 to 32, the most frequent being FUS, OPTN, SETX and VCP. NGS identified already known mutations in 21 genes, and new or rare variants in 27 genes. Conclusions: NGS seems to be a promising tool for the diagnosis of ALS in routine clinical practice. Its advantages are represented by an increased speed and a lowest sequencing cost, but patients’ counselling could be problematic due to the discovery of frequent variants of unknown significance
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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