19,030 research outputs found
Third Annual Conference on Privacy, Security and Trust
No full textThis pre-print appears as a courtesy only. Please see the conference proceedings for the definitive version. Ching-Lung Fu is the corresponding author
sj-docx-2-tar-10.1177_17534666221132731 – Supplemental material for Sequential treatment in advanced non–small cell lung cancer harboring EGFR mutations
No full textSupplemental material, sj-docx-2-tar-10.1177_17534666221132731 for Sequential treatment in advanced non–small cell lung cancer harboring EGFR mutations by Ping-Chih Hsu, John Wen-Cheng Chang, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Yueh-Fu Fang and Chiao-En Wu in Therapeutic Advances in Respiratory Disease</p
sj-tif-1-tar-10.1177_17534666221132731 – Supplemental material for Sequential treatment in advanced non–small cell lung cancer harboring EGFR mutations
No full textSupplemental material, sj-tif-1-tar-10.1177_17534666221132731 for Sequential treatment in advanced non–small cell lung cancer harboring EGFR mutations by Ping-Chih Hsu, John Wen-Cheng Chang, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Yueh-Fu Fang and Chiao-En Wu in Therapeutic Advances in Respiratory Disease</p
Development of taxane resistance in a panel of human lung cancer cell lines
No full textUsing a selection process designed to reflect clinically relevant conditions, a panel of taxane-selected variants were developed to study further the mechanisms of resistance in lung cancer. Unlike continuous or pulse exposure to high concentrations of chemotherapeutic drugs which yield high resistance and often cross resistance, most variants developed here displayed low level resistance to the selecting drug with slight cross-resistance. Pulsing with taxol resulted in more highly resistant clones (up to 51.4-fold). Analysis of taxol and taxotere in the four major lung cancer cell types showed the taxanes to be more effective against NSCLC (with the exception of SKMES-taxane selected variants) than against the SCLC. Comparison of taxol and taxotere shows that taxol induces higher levels of resistance than taxotere. Further, in taxotere-selected cell lines, the cells are more resistant to taxol than taxotere, suggesting that taxotere may be a superior taxane from a clinical view. Taxol treatment resulted in increased cross-resistance to 5-FU in all classes of lung cancer except DMS-53. The high levels of Pgp in the DMS-53 and selected variant suggests this mechanism is not related to Pgp expression. Analysis of the Pgp and MRP-1 status by combination inhibitory assays and Western blotting showed no consistent relationship between expression of the membrane pumps Pgp or MRP-1 and resistance. However, where high level resistance was seen, the parent cell line expressed Pgp or MRP-1 and was accompanied by increased levels in the variants. Overall we found that the clinically relevant models used here are useful for investigating mechanisms of taxane resistance
Neutrosophic combinatorics and its applications
No full textBased on the combined method in Chinese ancient I-Ching and theory of Taiji,
this paper presents the Neutrosophic combinatorics by means of the combinations of the truth, the falsehood, and the indeterminacy in Smarandache’s Neutrosophy. For the Neutrosophic combinatorics we can say that “Changes originate in the Taiji; from the Taiji come the 3 spheres
The Sao Style fu of the Middle Tang: Liu Zongyuan's Sao-style Fu中唐的騷學——柳宗元騷體文的命題藝術
No full textChinese Fu (Rhapsody): Genre Studies and Theories197-216Singapor
The Forced Migration of Wealthy People Fu-hu 富戸 to Pei-ching in the Early Ming Dynasty
No full textIn 1430, after the usurpation of the throne during the civil war of Ching-nan 靖難, Ch’eng-tsu 成祖 changed the name of the former capital to “Pei-ching” in order to take the first step towards transferring the capital to Pei-ching. Immediately after that, the Ming Dynasty started to force wealthy people mainly from all parts of the Chiang-nan region to move to Pei-ching. Past studies of this migration have been mainly based on the fu-hu sections in the 19th volume of the Ming-hui-tien 明会典. These studies concluded that the migrants and their descendants had been in large reduced to ruin by state expropriation. However, from the list of successful applicants in the highest examination and from inscriptions on tombs, we find that some of the migrants and their descendants succeeded in the imperial examinations and became bureaucrats. This paper identifies the individual migrants from these biographical materials and tries to present a concrete picture of the migration. The following conclusions were made.The migrants were selected out of the large landowners engaged in agricultural engagement. They were not forced to migrate with their clan and relatives. Migrants went to the northern parts of Pei-ching-ch’eng either single or with their families. After migration they engaged in agriculture or commerce. The Ming Dynasty intended to impose the corvee and the responsibility for providing government offices with food and materials in kind as well as include them in the lowest units of the administrative organization by appointing them as hsiang-chang 廂長 to manage the corvee. However, from the second generation of the migrants, severe state exploitation gave rise to desertion and the ruin of the fu-hu. In order to cope with this problem the Ming Dynasty devised the various counterplans for the security of the fu-hu. But in these plans the initial accent on the aforesaid location of fu-hu had become weaker, and the direct exploitation more severe. Especially since the silver commutation of fu-hu corvee which was introduced in 1492, the population of fu-hu residents in Pei-ching had decreased sharply. However, in the limited period of one hundred years since the migration, the fu-hu who passed the imperial examinations became bureaucrats. Through this period the process of “polarization” of the successful and the unsuccessful progressed.journal articl
Marilyn and Shen Fu : Studies in Connoisseurship, Chinese Paintings from the Arthur M. Sackler Collection in New York and Princeton
No full textChing-lang Hou. Marilyn and Shen Fu : Studies in Connoisseurship, Chinese Paintings from the Arthur M. Sackler Collection in New York and Princeton. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 64, 1977. pp. 332-334
Neutrosophic Interpretation of Tao Te Ching
No full textThe purpose of this book is to extend the foundation and application range of \u27Tao Te Ching\u27. The reasons for this are as follows. Firstly, we are willing to point out that \u27Tao Te Ching\u27 already has some limitation, because many questions we are interested in cannot be answered within \u27Tao Te Ching\u27. For example, \u27Tao Te Ching\u27 basically discussed the matters in China, however considering all possible situations it should matter in foreign countries as well, i.e. the “global village”. This was impossible in Lao Tzu’s time. Secondly, if the original “Tao Te Ching” is regarded as “Positive Tao Te Ching”, its opposite is “Negative Tao Te Ching”, while the intermediate or compound state is “Neutral Tao Te Ching”. Thus, our book presents the way to extend the original “Tao Te Ching” in various neutrosophic interpretations
The concept of peace in the Tao Te Ching
No full textThis thesis represents a first attempt to analyze Lao Tzu's main method of resolving the social and political problems in Ch'un Ch'iu and Warring States Periods. Lao Tzu, the founder of Taoism, suggested many solutions that could bring an end to the conflicts and to the ending of the disunity of China. Examples of these include the reform or abolishment of some ancient Chinese institutions as well as new principles for the enhancement and preservation of life. All these ideas were to become crystallised in Tao Te Ch'ing, which became an important religious text. In particular, the aspect of Lao Tzu's methods for solving the social and political problems of China in the Warring States Period needs more attention. In each chapter of the Tao Te Ch'ing there was a main emphasis on peace as the main method of developing social cohesion and as a cure to all fundamental human problems. Therefore, Lao Tzu's ideas about peace and his methods of solving the problems of the Warring States period are significant and from the main focus of the thesis
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