57,694 research outputs found
Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells.
No full textWe have studied the effects of thyrotropin (TSH) on the growth and on the levels of the mRNAs of the cellular proto-oncogenes, c-myc, and c-fos, in the specific target of TSH action, the thyroid follicular cell. FRTL5 cells, a cloned line from normal rat thyroid gland that depends upon TSH for its replication, were maintained in a quiescent state for 5 days by keeping them in a medium devoid of serum or TSH. The addition of bovine TSH (bTSH, 1 nM) increased DNA synthesis and stimulated cell proliferation after a lag period of 24 h. This growth response was anteceded by prompt, but transient, increases in the levels of c-myc and c-fos mRNAs, with peak responses at 60 and 30 min, respectively. The minimally and maximally effective concentrations of bTSH were 0.01 mM and 1.0 nM, respectively. Dibutyryl cAMP (Bt2cAMP) stimulated cell growth and increased the level of c-myc mRNA in a concentration-dependent manner, with maximum effects at a Bt2cAMP concentration of 1 mM. At the single concentration tested (1 mM), Bt2cAMP also increased the level of c-fos mRNA. Hence, bTSH-stimulated mitogenesis in quiescent FRTL5 cells is associated with rapid, but short-lived, increases in the levels of the mRNAs of the proto-oncogenes, c-myc and c-fos. Since bTSH is known to stimulate adenylate cyclase in these cells, and since the effect of TSH on c-myc and c-fos mRNAs is mimicked by Bt2cAMP, it is possible that these responses to bTSH are mediated, at least in part, by cAMP
Fishery resources and environmental conditions: The case of South Pacific albacore stocks (Thunnus alalunga)
No full textChin chin chinaman [music] : from the Japanese musical play The geisha /
No full textH & C 3774 (Publisher number). For voice and piano. Includes tonic sol-fa notation.; Cover title.; Pl. no.: H & C 3774.; "Sung by Mr Huntley Wright".; Also available online http://nla.gov.au/nla.mus-vn4601763.The geisha. Chin chin chinama
Two-to-one internal resonances in parametrically excited buckled beams
No full textThe response of a buckled beam possessing a two-to-one internal resonance to a principal parametric resonance of the higher mode is analyzed. The analysis assumes a unimodal static buckled deflection, considers quadratic nonlinearities only, and determines the amplitude and phase modulation equations via the method of multiple scales. Frequency- and force-response curves are generated. The force-response curves exhibit the saturation phenomenon. The equilibrium solutions of the modulation equations undergo saddle-node, pitchfork, and Hopf bifurcations. Dynamic solutions of the modulation equations are explored and a variety of bifurcation phenomena are documented, including period-doubling bifurcations, intermittency of type I, chaos, and crises
Letter from C. H. Gensler, Havasupai Agency to Carl Hayden
No full textLetter from C. H. Gensler expressing concern on behalf of the Havasupai Tribe regarding the proposed park boundaries
Citations of the author H C Rajpoot
No full textThe list of the articles, research papers, theses, and book chapters globally citing the author H. C. Rajpoot</p
Letter from Carl Hayden to C. H. Gensler
No full textLetter from Carl Hayden to C. H. Gensler informing him of the proposed Grand Canyon National Park bill
Letter from C. H. Gensler, Havasupai Agency to Carl Hayden
No full textLetter from C. H. Gensler to Carl Hayden asking for a meeting in regards to the Havasupai pasture land in light of the national park bill
chin music
No full textchin nGenerally "Chin music" refers to tunes sung without an accompanying instrument. Specifically, if refers to hymns sung in church witout an organ - not because of choice, but because the organist is not present, and there is nobody in the congregation to substitute for the organist. ( To wit - yesterday (Sunday) ... I went with my family to Gushue's Pong, only to be reminded after my return that "we had chin music in church today." Strangely enough the remark was derogatory, as in a village church where even the choir sings in "unison" and not always in the same key at the same time, "chin music" is the closest one can get to "cats howling in the wind."yesDNE-cit JH 4/72Used I and SupUsed I and SupNot usedCHIN MUSIC, MOUTH MUSICChecked by Cathy Wiseman on Sun 26 Apr 2015; Card marked DNE-cit, but not used
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