1,720,958 research outputs found
Prognostic Significance of Epithelial to Mesenchymal Transitions-Related Markers in Oral Squamous Cell Carcinoma
Get PDFThesis (M.Sc., Biomedical Sciences)--Prince of Songkla University, 2018Objective: We aimed to evaluate the association between the expression of E-cadherin and vimentin with clinicopathological characteristics and 5-year overall survival in oral squamous cell carcinoma (OSCC).
Material and methods: A total of 200 surgically resected OSCC patients treated during 2008-2011 were included. The protein expression analysis was performed using immunohistochemical technique on paraffin-embedded microarray tissue slides Immunoreactivity of proteins were classified into two groups using score of intensity multiplied by percentage of positive tumor cells. A combined analysis was performed using both E-cadherin and vimentin expression to determine Epithelial to mesenchymal transition (EMT) status. Kaplan-Meier method and log-rank test were used to compare the differences among survival curves. Cox-regression analysis was used to obtain independent prognostic factors.
Results: The median survival time was 48 months. Twenty-eight (14%) tumors showed loss of E-cadherin expression and 172 (86%) showed preserved E-cadherin expression. Vimentin was negative in 113 (56.5%) tumors and positive in 87(43.5%). E-cadherin (P=0.008) and EMT status (P=0.02) were significantly associated with lymph node metastasis. E-cadherin and vimentin were significantly associated with 5-year overall survival with HR 1.94, 95%CI (1.19-3.16) and HR 1.85, 95% CI (1.26-2.7) respectively. EMT status was also significantly associated with 5-year overall survival, the hazard ratio increased with EMT progression. Complete EMT (loss of E-cadherin expression and positive vimentin) status had higher hazard ratio then individual proteins (HR 2.88, 95% CI (1.44-5.79)).
Conclusion: Though both E-cadherin and vimentin expression could act as an independent prognostic factor, a combined evaluation of E-cadherin and vimentin expression to evaluate EMT status could provide a stronger indicator of prognosis in OSCC in addition to age, stage and treatment modality in surgically resected oral squamous cell carcinoma
The histopathological characteristics of gastric carcinoma in Bhutanese population: a Retrospective study
Get PDFIntroduction: Gastric cancer is not only the most common cancer, but also the cancer with the highest mortality in Bhutan. The baseline data on the histological phenotype of gastric cancer in Bhutan is not established. Different histological phenotypes have distinct etiology, clinical features, and prognosis. We aimed to assess the histological phenotypes of gastric carcinoma, evaluate the grading, staging, and the association of depth of invasion with the clinicopathological findings.
Methods: We conducted a retrospective study, involving 494 cases diagnosed with gastric carcinoma from January 2018 to June 2021. The histopathological characteristics of the patients were presented in frequency, percentage, and mean ± standard deviation.
Results: Gastric carcinoma was most prevalent in males (60.7%) and predominantly diagnosed in patients more than 60 years of age (67.6%). Antrum (76.5%) was the most common location for gastric carcinoma, and tubular adenocarcinoma (81.6%) was the most common histological phenotype in this study followed by poorly cohesive carcinoma, signet-ring-cell type (12.8%). Most of the patients were at an advanced stage (pT4) at the time of diagnosis (32.7%).
Conclusions: The histopathological characteristics of gastric carcinoma in the Bhutanese population were similar to regions with high gastric cancer incidence with the preponderance of distal location of the tumor and tubular adenocarcinoma being the most common subtype. As established in other regions, gastric carcinomas were more prevalent among males and patients over 60 years in Bhutan
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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