1,720,991 research outputs found
IMPROVED ENZYMATIC-HYDROLYSIS OF HAIR
No full textAn enzymatic hair extraction method is proposed for drug analysis. Pronase digestion of various aliquots of hair from a cocaine abuser was preceded by a 2-h incubation with a dithiothreitol solution. The extraction solution was tested to identify possible interferences in the radioimmunoassay and was compared with other hydrolysis methods to assess the results of extraction
SEGMENTAL HAIR ANALYSIS FOR COCAINE AND HEROIN ABUSE DETERMINATION
No full textSegmental hair analysis was performed to obtain information about the history of drug abuse of subjects in a rehabilitation programme. The analytical data from hair samples were correlated, when possible, with urine analysis and to toxicological anamnesis. Toxicological analysis of hair seems to be a valid tool in this specific field
MATRICI NON CONVENZIONALI IN TOSSICOLOGIA FORENSE.
No full textL’uso di matrici biologiche cosiddette ‘alternative’ (rispetto a quelle considerate ‘convenzionali’ come il sangue e l’urina) deriva dalla necessità di individuare strumenti più versatili ed in grado di fornire dati tossicologici precisi ed attendibili, anche riguardo ai tempi di assunzione di sostanze psicoattive.
L’avanzamento delle tecniche analitiche rende oggi possibile l’utilizzo di matrici biologiche più complesse e/o di cui sono disponibili quantità inferiori, più facili da prelevare e più difficilmente adulterabili. Viene effettuata una panoramica delle possibilità, delle caratteristiche di diversi campioni biologici, delle applicazioni e delle metodiche analitich
Solid-phase microextraction (SPME) and gas-chromatographic analysis of anorectic compounds in human urine
No full textSPME has been applied for the determination of anorectic compounds in urine of user
DRUG DISTRIBUTION IN THE HEAD, AXILLARY AND PUBIC HAIR OF CHRONIC ADDICTS
No full textThis study investigates the distribution of some drugs in hair samples taken from different parts of the body (head, pubis and axillae). Samples drawn from 15 subjects who died from drug overdose were analysed. The concentrations of the drugs detected in the biological fluids did not appear to be correlated with those present in hair. The highest drug levels were observed in pubic hair. The concentration differences observed in the various types of hair can hypothetically be ascribed to a likely incorporation of the drugs from the outside
La ricerca delle sostanze d'abuso in campioni di capelli
No full textvengono descritte le più attuali metodologie per la preparazione ed analisi di campioni di capelli per la determinazione di droghe d'abus
Application of hair analysis to document coercive heroin administration to a child.
No full textThis paper describes the application of hair analysis in a judicial case to document coercive heroin administration to a 5-year-old child, who was admitted with overdose symptoms to an intensive care division. Segmental hair analysis was performed in order to determine if drug consumption had continued. Quantitative results showed the presence of morphine and O-6-monoacetylmorphine (MAM) in increasing amounts from the second to the distal segment of hair, each approximately corresponding to a period of time of one month. MAM concentrations ranged from 0.2 ng/mg in the second segment of hair to 0.6 ng/mg in the distal segment; morphine concentrations ranged from 0.1 to 0.3 ng/mg. Limits of detection were 0.1 ng/mg for morphine and 0.2 ng/mg for MAM. The proximal segment of hair, which corresponded to the period that the child was housed in a social center, was negative for opiates
Hair analysis in anti-doping tests: Potential and prospects [L'analisi dei capelli nei controlli antidoping: Potenzialita e prospettive]
No full textUnder current IOC (International Olympic Committee) regulations an athletes dope test is only described as positive if the actual presence (in some cases in concentrations above a certain threshold limit) can be identified of drugs and/or their metabolites which appear on the IOC's own list of prohibited substances and methods. The present paper describes the use of keratin matrices for antidoping test purposes and discusses their potential and limitations. Particular attention is paid to analysing hair samples for traces of drugs and/or metabolites with reference to the specific classes of prohibited substances. The possibility of using hair sample analysis as a means of distinguishing between the occasional and regular intake of given drugs is examined in particular detail in the belief that it may be possible to obtain experimental data of a pharmacokinetic nature which would make it possible to differentiate between the illegal use of a prohibited substance for performance-enhancing purpose and its ingestion for legitimate medical reasons. Finally the paper examines aspects relating to the applicability of hair tests in the framework of the IOC's anti-doping surveillance with emphasis on the importance of guaranteeing at least the same level of confidentiality, reliability and reproducibility as currently apply to urine test
Analytical techniques in androgen anabolic steroids (AASs) analysis for antidoping and forensic purposes.
No full textA survey on the main analytical challenges related to the analysis of Androgen Anabolic Steroids (AAS) is reported. AAS analysis is an issue regarding antidoping analyses as well as forensic toxicology applications. This paper reports an overview of the more recent literature regarding various aspects of sample preparation, analytical techniques and interpretation of results for AAS identification in biological samples. New analytical approaches, mainly for their application to the antidoping field, are reported. The application of AAS in forensic cases is also described, taking into consideration mainly the different biological samples that can be analysed for forensic purposes. Particular attention was played on the application of hair analysis as alternative biological specimen for the determination of AAS abuse
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