1,720,974 research outputs found
L'ipotesi autoimmune nel disturbo ossessivo-compulsivo: studio immunologico su un campione di pazienti adulti
No full textAB Background: An autoimmune hypothesis has been suggested for a subtype of Obsessive-Compulsive Disorder (OCD); this hypothesis was investigated particularly in children, while only two studies assessed samples of adult patients. Aim of the study: To evaluate in a sample of adult OCD patients: a) the proportion of subjects with antibodies directed towards neuronal structures; b) with high ASLO titers and/or with markers of autoimmunity measured in the practice of neurology and internal medicine. Materials and methods: 74 OCD patients consecutively referred to the Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin were recruited; as control group, 44 patients with a current major depressive episode consecutively referred to the same Unit were recruited. Structured and semi-structured interviews were used to collect data. Anti-brain antibodies were tested by immunohistochemistry and western-blotting methods. Results: 5.4% of the OCD sample resulted positive for anti-brain antibodies and there was an association with an earlier onset of symptoms. 10.3% of OCD subjects had high mean ASLO titers and this was correlated with a pre-pubertal onset of symptoms. No other significant differences in antibody parameters were found. Conclusions: In a small proportion of OCD patients autoimmune reactions towards neuronal structures are present. Further investigations are needed to demonstrate a possible autoimmune etiopathogenesis in this subtype of OCD, in order to open new therapeutic scenarios
Sindrome metabolica e disturbi psichiatrici: confronto stratificato per età e sesso tra disturbo bipolare e disturbo ossessivo-compulsivo
No full textMetabolic syndrome in Italian patients with bipolar disorder
No full textObjective: This study aimed to evaluate the prevalence of metabolic syndrome (MetS) in Italian patients with bipolar disorder (BD) and to
determine the sociodemographic and clinical correlates of MetS in this patient population.
Method: Subjects with BD I and II were included. Sociodemographic and clinical characteristics, lifestyle information (alcohol and smoking
habits and rate of physical exercise) and comorbidity for cardiovascular diseases and diabetes were collected. Patients were assessed for MetS
according to both National Cholesterol Education Program Adult Treatment Panel III and International Diabetes Federation (IDF) criteria.
Results: MetS was evaluated in 99 patients out of 108 who were enrolled. MetS was present in 25.3% of the sample. Abdominal obesity was
present in 50%, hypertension in 40%, high triglycerides in 34.7%, low HDL-C levels in 32.3% and fasting hyperglycemia in 11% of the
sample. Prevalence of MetS was 30% when IDF criteria were employed. Of the investigated variables, age, duration of illness, rate of obesity
and cardiovascular disease were higher in patients with MetS. After the regression analysis, only age and obesity were associated to MetS.
Conclusions: MetS is highly prevalent in Italian patients with BD. Our 25.3% prevalence rate is consistent with the 21–22% reported in
other European studies and lower than that in U.S. studies. Elderly and obese patients with BD are at particularly high risk for MetS.
© 2008 Elsevier Inc. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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