16 research outputs found
Integrated digital survey methodologies for the knowledge and enhancement of the ancient city walls. The “Curtain” of Santa Chiara in Cagliari (Italy)
No full textThe contribution shows some results of a multidisciplinary research in which architectural surveying and representation methods are supported by archival documents analysis. The procedure is applied in a limited area of the ancient walls of Cagliari (Sardinia, Italy). The sector consists in the meet point between the sixteenth century bastion called “Curtain” of Santa Chiara realized in the period 1575-1578 by the military engineer Giorgio Paleari and the curtain of de Cardona commissioned by the Viceroy in the 30s of the same century. The historical documents indicates the presence of medieval structures, vaulted chamber and passages designed and built during this period. This source, supported by the knowledge of construction techniques indicated in the military treaties, allows a first graphic representation of the sixteenth century bastion, of which today we can only recognize a part of the vaulted gun chamber positioned along the curtain of de Cardona
Hair analysis for beta‐blockers and calcium‐channel blockers by using liquid chromatography‐tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy
No full textAdherence to therapy is the key to a successful therapeutic intervention, especially in cardiovascular diseases in which a lack of adherence may have serious consequences in terms morbidity and/or mortality. In this context, hair analysis can be an excellent tool to monitor adherence to therapy. Indeed, drugs present in blood are incorporated into the hair matrix, where drugs and metabolites can stay unaltered for a long time protected from metabolism and degradation. In the present study, a simple, specific, and sensitive ultra-high performance liquid-chromatography-tandem mass spectrometry (UHPLC-MS/MS) method set up to determine in human hair seven beta-blockers (viz., metoprolol, sotalol, labetalol, atenolol, nebivolol, bisoprolol, and nadolol) and two calcium-channel blockers (lercanidipine and amlodipine), which are widely prescribed to treat medium-to-severe hypertensive conditions. The optimized method was successfully validated in terms of accuracy, repeatability, reproducibility, matrix effect and extraction recovery. Moreover, the applicability of the method was evaluated by analyzing 34 real samples of hair obtained from patients under long-term therapy with calcium channel blockers and beta-blockers
Integrated methodologies for the knowledge, representation and protection of historical military architecture. Construction systems and vaulted paths along the western bastions of Cagliari (Sardinia, Italy)
No full text[EN] The integrated method is been applied in the meet point between the curtain of Santa Chiara and the curtain of de Cardona, in a limited area of the ancient walls of Cagliari (Sardinia, Italy). The sector consists
of a bastion called “curtain of Santa Chiara” designed in 1575 and realized in the period 1575-1578 by
the military engineer Giorgio Paleari and the “curtain of de Cardona”, a military work commissioned by
the Viceroy in the 1930s of the same century and interested by modification until the seventeenth century.
The archive documents offer a lot of informations on the presence of gunboats and vaulted passages
designed and built in this area during this period. This source –accompanied by an architectural survey
of the existing military work and the knowledge of the construction techniques used at the time and indicated in the military treaties– may direct a subsequent investigation with geophysical methods. To this
aim, a first graphic representation of the study area in the sixteenth century is proposed.Pirinu, A.; Bagnolo, V.; Argiolas, R.; Utzeri, M. (2020). Metodologie integrate per la conoscenza, la tutela e la rappresentazione dell’architettura militare storica. Sistemi costruttivi e percorsi voltati lungo i bastioni occidentali di Cagliari (Sardegna, Italia). Editorial Universitat Politècnica de València. 1343-1350. https://doi.org/10.4995/FORTMED2020.2020.11378OCS1343135
Metodologie integrate per la conoscenza, la tutela e la rappresentazione dell’architettura militare storica. Sistemi costruttivi e percorsi voltati lungo i bastioni occidentali di Cagliari (Sardegna, Italia)
No full textThe integrated method is been applied in the meet point between the curtain of Santa Chiara and the curtain of de Cardona, in a limited area of the ancient walls of Cagliari (Sardinia, Italy). The sector consists of a bastion called “curtain of Santa Chiara” designed in 1575 and realized in the period 1575-1578 by the military engineer Giorgio Paleari and the “curtain of de Cardona”, a military work commissioned by the Viceroy in the 1930s of the same century and interested by modification until the seventeenth century.
The archive documents offer a lot of informations on the presence of gunboats and vaulted passages designed and built in this area during this period. This source –accompanied by an architectural survey of the existing military work and the knowledge of the construction techniques used at the time and indicated in the military treaties– may direct a subsequent investigation with geophysical methods.
To this aim, a first graphic representation of the study area in the sixteenth century is proposed
Deepening the knowledge of military architecture in an urban context through digital representations integrated with geophysical surveys. The city walls of Cagliari (Italy)
No full textThis paper shows some results of a multidisciplinary study including digital surveys integrated with geophysical investigations. The procedure is applied in the city of Cagliari, Italy, in the area of the ancient walls between the bastion of Santa Croce and the fourteenth-century Elephant Tower. This sector consists of the curtain of Santa Chiara, designed in 1575 and completed in the years 1576-1578 by the military engineer Giorgio Paleari. The archival documents offer precise indications on the collapses and the reconstructions/expansions that took place in that period, so facilitating a recognition of the events. Compared to the medieval walls, the work of Paleari brought forward the line of defense by means of a robust embankment and incorporated two of the fifteenth-century towers described in the drawings of the military engineers of the time. In the eighteenth century, the front was completed with the construction of a lowered embankment leaning against the southern side of the bastion of Santa Croce and the curtain of Santa Chiara. More recently, both the bastion and the sixteenth century curtain have been reinforced by means of several restoration and consolidation works. The latter changed the profile of the parapet –in the origin it was inclined- and the static balance of the constructive system by means of reinforced concrete piles. The survey methods and techniques used in this study provide interesting information about the current structure of the bastion system, such as the presence of vaulted passages functional to the military work. A further study campaign mainly based on seismic tomography techniques is proposed
Indagini per la conoscenza e la tutela dell'architettura militare storica. Il fronte occidentale delle fortificazioni di Cagliari (Sardegna, Italia)
No full textThis contribution shows some results of a multidisciplinary survey, which includes the integration of architectural surveying methods and geophysical methods. The operative procedure is applied in the portion of the ancient walls between the bastion of Santa Croce and the fourteenth-century Elephant Tower, in the city of Cagliari, Italy. The sector under study consists of 1) the wall curtain of Santa Chiara designed in 1575 by the engineer Giorgio Paleari and 2) the de Cardona wall curtain, a work commissioned by the Viceroy in the 30s of the same century. The archival documents offer precise indications on the extent of the collapses and the reconstructions/expansions that took place in that period, so facilitating a recognition of the events that took place. The work of the sixteenth century -brought to completion by the same Giorgio Paleari in the years 1576-1578- advances the line of defense with respect to the border of medieval matrix by means of a robust embankment, and incorporates two of the fifteenth-century towers described in the drawings of the military technicians of the time. In the eighteenth century the front was completed by the construction of a lowered embankment near the southern side of the bastion of Santa Croce and the curtain of Santa Chiara, and more recently it has been improved by means of several restorations and consolidations that changed the profile of the parapet –in the origin it was inclined - and the static balance of the constructive system, also through the use of reinforced concrete piles. The application of the survey methods and techniques used in this study provides interesting information about the current structure of the bastion system and the presence of vaulted passages functional to the military work. A new study campaign mainly based on seismic geophysical techniques is proposed
Development and Characterization of Phosphorus-Free Biosilicate® Scaffolds Obtained via Stereolithography for Bone Tissue Regeneration Applications
No full textreservedIl presente lavoro di tesi approfondisce lo sviluppo e la caratterizzazione di compositi a matrice vetro-ceramica progettati per favorire la rigenerazione del tessuto osseo. L’obiettivo è la produzione di scaffold con un’elevata porosità di Biosilicate® (circa 85%) mediante Additive Manufacturing, utilizzando in particolare la tecnica di Stereolitografia attraverso l’impiego della stampante Prusa SL1S, la quale permette di ottenere dei campioni ad alta risoluzione con geometria e porosità controllate. Un aspetto cruciale della ricerca è la verifica della corrispondenza topologica attraverso l'intero processo di fabbricazione: dal modello digitale iniziale all'oggetto stampato fisicamente, fino alla sua trasformazione nella struttura ceramica finale.
Per la realizzazione degli scaffold sono stati utilizzati i PDC (polymer-derived ceramics), i quali permettono di ottenere materiali trasformabili, come la conversione da siliconi a silice e carbonio, attraverso dei trattamenti termici. La miscela sviluppata è costituita da due fasi separate: una fase oleosa che include il precursore siliconico H44 e una parte della resina, e una fase continua in cui si trovano la restante resina, l'emulsionante Span 80, il nitrato di calcio tetraidrato e l'acetato di sodio. È importante sottolineare che, a differenza di altri studi, la miscela utilizzata è priva di fosforo, poiché i precursori di fosforo compromettono la stabilità dell'emulsione.
A seguito della stampa 3D, le strutture a geometria di tipo giroide realizzate sono state sottoposte a trattamenti termici in atmosfera controllata in azoto e in aria. Successivamenteè stata valutata la risposta meccanica attraverso prove di compressione. La porosità, parametro chiave per l’applicazione in ambito biomedico, è stata quantificata mediante analisi picnometrica. L’analisi della morfologia è stata effettuata con l’utilizzo della microscopia ottica e la microscopia elettronica a scansione (SEM). Infine, la composizione delle fasi cristalline formatesi dopo i trattamenti termici è stata determinata mediante diffrazione a raggi X(XRD).
La caratterizzazione completa dei materiali e la valutazione della loro morfologia e proprietà meccaniche hanno permesso di raggiungere gli obiettivi prefissati, fornendo una solida base per future applicazioni in vivo.This thesis focuses on the development and characterization of glass-ceramic matrix composites designed to promote bone tissue regeneration. The aim is to produce scaffolds with high porosity (around 85%) of Biosilicate® using Additive Manufacturing, specifically through the Stereolithography technique with the Prusa SL1S printer. This method enables the production of high-resolution samples with controlled geometry and porosity. A crucial aspect of the research is verifying topological consistency throughout the entire manufacturing process: from the initial digital model to the physically printed object, and finally, to its transformation into the final ceramic structure.
For scaffold production, Polymer-Derived Ceramics (PDC) were used, enabling the creation of materials that can undergo transformations, such as the conversion from silicones to silica and carbon through thermal treatments. The developed mixture consists of two separate phases: an oily phase containing the silicon precursor H44 and part of the resin, and a continuous phase containing the remaining resin, the emulsifier Span 80, calcium nitrate tetrahydrate, and sodium acetate. Notably, unlike other studies, this mixture is phosphorus-free, as phosphorus precursors would compromise the stability of the emulsion.
After 3D printing, the gyroid-shaped structures were subjected to thermal treatments in controlled nitrogen and air atmospheres. The mechanical properties were then evaluated through compression tests. Porosity, a critical parameter for biomedical applications, was quantified using pycnometric analysis. Morphological analysis was performed with optical and scanning electron microscopy (SEM). Finally, the crystalline phase composition formed after thermal treatments was determined by X-ray diffraction (XRD).
The detailed characterization of the materials and the evaluation of their morphology and mechanical properties have successfully met the research objectives, providing a solid foundation for future in vivo applications
Dataset of the work "Straightforward purification method for the determination of the activity of glucose oxidase and catalase in honey by extracting polyphenols with a film-shaped polymer"
No full textThe dataset contains all raw data of the work "Straightforward purification method for the determination of the activity of glucose oxidase and catalase in honey by extracting polyphenols with a film-shaped polymer"We gratefully acknowledge the financial support provided by all funders. Author Saul Vallejos received funding from "La Caixa" Foundation Grant LCF/PR/PR18/51130007. Author Jose Miguel García received funding from “Spanish Agencia Estatal de Investigación " Grant PID2020-113264RB-I00 / AEI / 10.13039/501100011033. Ana Arnaiz received funding from Ministerio de Universidades-European Union in the frame of NextGenerationEU RD 289/2021 (Universidad Politécnica de Madrid). We also gratefully acknowledge European Regional Development Fund (ERDF). Gianluca Utzeri thanks Fundação para a Ciência e a Tecnologia (FCT, Portugal) for PhD grant (SFR/BD/146358/2019). The Coimbra Chemistry Centre is supported by the FCT, through Projects UIDB/00313/2020 and UIDP/00313/2020
Dataset of the work "UBU-Polymers Research Group 27022024"
No full textThe dataset contains all raw data of the work "Reusable and Effective Polyacrylic Membranes for Mecoprop and Bentazon Extraction"We gratefully acknowledge the financial support provided by all funders. The financial support provided by Fondo Europeo de Desarrollo Regional-European Regional Development Fund (FEDER, ERDF) and Regional Government of Castilla y León -Consejería de Educación, Junta de Castilla y León- (BU025P23) is gratefully acknowledged. This work was supported by the Regional Government of Castilla y León (Junta de Castilla y León) and by the Ministry of Science and Innovation MICIN and the European Union NextGenerationEU PRTR. Author J. M. García received grant PID2020-113264RB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”. Author Saul Vallejos received grant BG22/00086 funded by Spanish Ministerio de Universidades. The authors also acknowledge Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Agency for Scientific Research for the financial support through project UIDP/00313/2020. Tania Cova acknowledges the Junior Researcher Grant CEECIND/00915/2018 assigned by FCT. Gianluca Utzeri thanks FCT for the PhD grant SFR/BD/146358/2019
Efficient extraction of textile dyes using reusable acrylic-based smart polymers
No full textWater pollution from industrial or household waste, containing dyes from the textile industry, poses a significant environmental challenge requiring immediate attention. In this study, we have developed a crosslinked-smart-polymer film based on 2-(dimethylamino)ethyl methacrylate copolymerized with other hydrophilic and hydrophobic commercial monomers, and its efficacy in removing 21 different textile dyes was assessed. The smart polymer effectively interacts with and adsorbs dyes, inducing a noticeable colour change. UV-Vis spectroscopy analysis confirmed a removal efficiency exceeding 90 % for anionic dyes, with external diffusion identified as the primary influencing factor on process kinetics, consistent with both pseudo-first-order kinetics and the Crank-Dual model. Isothermal studies revealed distinct adsorption behaviors, with indigo carmine adhering to a Freundlich isotherm while others conformed to the Langmuir model. Permeation and fluorescence analyses corroborated isotherm observations, verifying surface adsorption. Significantly, our proof-of-concept demonstrated the resilience of the smart-film to common fabric softeners and detergents without compromising adsorption capacity. Additionally, the material exhibited reusability (for at least 5 cycles), durability, and good thermal and mechanical properties, with T5 and T10 values of 265 °C and 342 °C, respectively, a Tg of 168 °C, and a water swelling percentage of 54.3 %, thus confirming its stability and suitability for industrial application.We gratefully acknowledge the financial support provided by all funders. This work was supported by the Regional Government of Castilla y León (Junta de Castilla y León) and by the Ministry of Science and Innovation MICIN and the European Union NextGenerationEU PRTR. Author Saul Vallejos received grant BG22/00086 funded by Spanish Ministerio de Universidades. Author Marta Guembe-García received funding from the Spanish Ministerio de Universidades-European Union under the framework of NextGeneration EU RD 289/2021 for her Post-Doc position. Author Jose Miguel García received grant PID2020-113264RB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”, and grant TED2021–129419B-C21 funded by MCIN/AEI/ 10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR”. The financial support provided by Fondo Europeo de Desarrollo Regional-European Regional Development Fund (FEDER, ERDF) and Regional Government of Castilla y León -Consejería de Educación, Junta de Castilla y León- (BU025P23) is gratefully acknowledged. Artur Valente and Gianluca Utzeri thank the financial support from The Coimbra Chemistry Centre through Projects UIDB/00313/2020 and UIDP/00313/2020 (FCT)
