47,736 research outputs found
General Chiang Kai-shek : the builder of new China
No full textGeneral Chiang Kai-shek"Significant speeches [by General Chiang]": p. [51]-107.by Chen Tsung-hsi, Wang An-tsiang and Wang I-ting; with an introduction by Dr. Chenting T. Wang and a preface by Dr. Wang Chung-hui
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Full text linkIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Short-Term Efficacy and Safety of Bisoprolol in Treatment of Patients with Mild to Moderate Essential Hypertension:A Two-Center, Double-Blind Study in Taiwan
No full textDevelopment of surrogate organic contaminant parameters for source water quality standards in Taiwan, ROC
No full textA probability-based multivariate statistical algorithm for autofluorescence spectroscopic identification of oral carcinogenesis
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