219 research outputs found
sj-docx-1-cll-10.1177_09636897241237049 – Supplemental material for Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury
No full textSupplemental material, sj-docx-1-cll-10.1177_09636897241237049 for Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury by Ya-Ni Huang, Nigel H. Greig, Pen-Sen Huang, Yung-Hsiao Chiang, Alan Hoffer, Chih-Hao Yang, David Tweedie, Ying Chen, Ju-Chi Ou and Jia-Yi Wang in Cell Transplantation</p
Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC
No full textPMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
sj-jpg-3-cll-10.1177_09636897231211067 – Supplemental material for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation
No full textSupplemental material, sj-jpg-3-cll-10.1177_09636897231211067 for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation by Yen-Ta Chen, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Pei-Lin Shao, Chi-Ruei Huang, Mel S. Lee and Hon-Kan Yip in Cell Transplantation</p
sj-jpg-1-cll-10.1177_09636897231190178 – Supplemental material for Early and Dose-Dependent Xenogeneic Mesenchymal Stem Cell Therapy Improved Outcomes in Acute Respiratory Distress Syndrome Rodent Through Ameliorating Inflammation, Oxidative Stress, and Immune Reaction
No full textSupplemental material, sj-jpg-1-cll-10.1177_09636897231190178 for Early and Dose-Dependent Xenogeneic Mesenchymal Stem Cell Therapy Improved Outcomes in Acute Respiratory Distress Syndrome Rodent Through Ameliorating Inflammation, Oxidative Stress, and Immune Reaction by Kun-Chen Lin, Wen-Feng Fang, Pei-Hsun Sung, Kuo-Tung Huang, John Y. Chiang, Yi-Ling Chen, Chi-Ruei Huang, Yi-Chen Li, Mel S. Lee and Hon-Kan Yip in Cell Transplantation</p
sj-docx-1-cll-10.1177_09636897231211067 – Supplemental material for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation
No full textSupplemental material, sj-docx-1-cll-10.1177_09636897231211067 for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation by Yen-Ta Chen, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Pei-Lin Shao, Chi-Ruei Huang, Mel S. Lee and Hon-Kan Yip in Cell Transplantation</p
sj-jpg-2-cll-10.1177_09636897231211067 – Supplemental material for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation
No full textSupplemental material, sj-jpg-2-cll-10.1177_09636897231211067 for Prion Protein Overexpression in Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Effectively Protected Rodent Kidney Against Ischemia-Reperfusion Injury Via Enhancing ATP/Mitochondrial Biogenesis—Role of ADMSC Rejuvenation and Proliferation by Yen-Ta Chen, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Pei-Lin Shao, Chi-Ruei Huang, Mel S. Lee and Hon-Kan Yip in Cell Transplantation</p
sj-docx-1-cll-10.1177_09636897221133821 – Supplemental material for Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings
No full textSupplemental material, sj-docx-1-cll-10.1177_09636897221133821 for Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings by Tsung-Cheng Yin, Pei-Lin Shao, Kuan-Hung Chen, Kun-Chen Lin, John Y. Chiang, Pei-Hsun Sung, Shun-Cheng Wu, Yi-Chen Li, Hon-Kan Yip and Mel S. Lee in Cell Transplantation</p
A Model of Chronic Lymphocytic Leukemia with Ritcher's Transformation in Severe Combined Immunodeficiency Mice
No full textObjective. The major aim of the study was to establish a murine model of chronic lymphocytic leukemia with B-1 cells derived from a New Zealand white mouse.Material and Methods. Malignant B-1 cells (named CLL-RT cells) derived from a New Zealand white mouse were injected into the peritoneal cavity of severe combined immunodeficiency mice. Upon follow -up of recipient mice, the lymphomas showed characteristics similar to chronic lymphocytic leukemia (CLL) with Ritcher's transformation.Results. Blood samples from the recipient mice showed that CLI-RT cells increased rapidly in peripheral blood after 5 weeks. Serum interleukin-10 also increased significantly in recipient mice, as in human chronic lymphocytic leukemia patients. These CLL-RT cells showed a high nucleus-to-cytoplasm ratio. These cells could metastasize via circulation in the recipients and form diffuse lymphomas in various tissues. These aggressive and diffuse lymphomas were similar to Ritcher's transformation of human CLL. The cell surface antigens of the spleen and peritoneal resident cells were analyzed by flow cytometry. The CLL-RT cells constantly expressed surface immunoglobulins M and G, and CD5, CD19, B220, and CD40 molecules. They did not express any CD11b, CD3, MAC-3, CD23, NK1.1, or H-2K(d) molecules. Conclusions. The characteristics of our animal model are very similar to human CLL This animal system could be an ideal model for the human disease . We believe the animal model would be valuable in therapeutic studies and aid in the identification of the specific genetic alleles associated with the disease. (C) 2001 International Society for Experimental Hematology. Published by Elsevier Science Inc
Recent advances in immunotherapy of B-CLL using ex vivo modified dendritic cells
No full textChronic lymphocytic leukemia (CLL) results from the relentless accumulation of small mature, slowly dividing, monoclonal B-lymphocytes. The clinical course is heterogeneous, some patients with aggressive form of the disease progressing rapidly with early death while others exhibit a more stable, possibly, non-progressing indolent type of the disease lasting many years. Despite progress in modern treatment modalities, relapse invariably occurs and disease still remains incurable. The clinical management of CLL is therefore challenging and considerable effort has been directed towards novel therapeutic strategies aimed at reducing minimal residual disease which can increase remission duration. Recent insight into the role of dendritic cells (DCs) as pivotal antigen presenting cells that initiate immune responses may provide the basis for generating more specific and effective immune responses. Ex-vivo modified and monocyte-derived DCs represents a promising approach within the context of CLL. However, understanding the relationship between DCs and the cellular immune response is crucial in devising strategies for manipulating immune responses. After a brief survey of general properties of DCs, this review focuses on the different approaches exploiting monocyte-derived DCs in CLL, which may help to design novel strategies for phase-I clinical trials
The nonsense of copyright in libraries : digital information and the right to copy
No full textThe notion of copyright is deeply entrenched in the psyche of librarians, who remain one of the few groups who consistently support or uphold it. Given the growth of digital information and consequential change in the behaviour of information creators and users the paper posits that copyright administration in libraries has become a cumbersome burden whose “time has come”. Changes in information provision by libraries towards delivering more digital information have ironically highlighted the paradox libraries face between providing the best possible service and upholding copyright. The notion that there exists in the digital environment a “right to copy” is put forward. Copyright is legally complicated, controversial, subject to a number of misunderstandings and generally not fully understood even by the librarians whose daily tasks include administering it. To better understand the current status of copyright and its impact on libraries the notion of copyright is briefly outlined, along with what exactly copyright is, its historical roots and its suitability in the current environment. In examining the legislation the paper critiques its aims and how it fails in these; compares arguments in favour and against its retention, investigates how it serves to restrict creativity rather than encourage it and in closing suggests why libraries should abandon the struggle to uphold copyright. Examples from New Zealand, Australia, the US and the UK are used to highlight inconsistencies that support the argument that copyright in the digital environment is a nonsense that no longer works
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