7,771 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
General Chiang Kai-shek : the builder of new China
No full textGeneral Chiang Kai-shek"Significant speeches [by General Chiang]": p. [51]-107.by Chen Tsung-hsi, Wang An-tsiang and Wang I-ting; with an introduction by Dr. Chenting T. Wang and a preface by Dr. Wang Chung-hui
The two widows: a comparison of the educational influence of Krupskaya, wife of Lenin and Chiang Ch'ing, wife of Mao
No full textA dissertation submitted to the Faculty of Education, University of the
Witwatersrand, Johannesburg, in partial fulfillment of the requirements
for the Degree of Master of Education.
Johannesburg, 1962.This dissertation studies the educational influence of two women. One of
these women is Nadezhda K. Krupskaya (1863 - ,936), wife of Lenin who was
Premier of the U.S.S.A. The other woman is Chiang Ch-ing fbo m in 1914
and still alive today), third wife of Mao Tse-Tung who was Chairman of
the People's Republic of China. Both Krupskaya and Chiang Ch'ing had
Marxist backgrounds, and both carried out the political ideologies of
their husbands.
Krupskaya was a pedagogist who stressed especially the need for polytechnical
education in the school. She believed that this type of learning
would contribute greatly towards fulfilling the ..pciai and economic
reouirements of a communist society. Chiang Ch'ing, in contrast to
Krupskaya, had little education. While assisting Mao in implementing his
re dims in the schools during the Great Proletarian Cultural Revolution
her greatest influence was in the area of China's national culture
Having gained supreme authority in this sphere, she turned the performing
arts into a vehicle for Mac's ideas which were to serve Proletarian politics.
Krupskaya's polytechnics! concepts are today stressed at every stage of
the Russian educational system. Despite this, however, it has been found
that Russian schooling produces an inegalitarian society, which is in conlict
with the ideals postulated.
After Mac's death, Chiang Ch'ing, with the other members of the 'Gang of
Pour' of which she was ringleader, was arrested and imprisoned. The new
leaders, while systematically restoring ore-Cultural Revolution policies
used the 'Gang of Four' as scapegoats in their political campaign.
Chiang Cn'ing has been denounced as a traitor, and all vestiges of her
influence have been eradicated
Pathogenicity of a baculovirus infection causing white spot syndrome in cultured penaeid shrimp in Taiwan.
No full textAutophagy involved in the improvement of DHA on cardiomyocyte death resulting from oxidative stress.
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Disseminated tuberculosis presenting as multiple hepatosplenic microabscesses and pancytopenia in a teenage boy
No full textLow genetic variation in Amentotaxus formosana Li revealed by isozyme analysis and random amplified polymorphic DNA markers.
No full textHMB-45 may be a more sensitive matker than S-100 or Melan-A for immunohisstochemical diagnosis of primary oral and nasal mucosal melanomas.
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