10,516 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Discovering the Essential Power of T\u27ai Chi Ch\u27uan: The Yin and Yang of Leadership
No full textThe focus of this study was to determine a possible relationship between T’ai Chi Ch\u27uan and organizational leadership. Specifically, this study assessed whether or not the principles and practice o f T’ai Chi Ch’uan can be used to assist with solving problems in organizational leadership. Through a detailed analysis of key principles of T’ai Chi Ch’uan and its movements, the author attempted to demonstrate the effectiveness and relevance of T’ai Chi Ch’uan to organizational leadership. First, the positive physiological, mental, and psychological effects of T’ai Chi Ch’uan on people were considered on an organizational level. Second, the principles o f T’ai Chi Ch’uan were translated into business strategies that may be used effectively in negotiations and communication. Finally, the concept of organizational health was discussed in relation to T’ai Chi Ch’uan. Essentially, this study addressed how T’ai Chi Ch’uan can be used to enhance the organizational health of contemporary organizations
FIGURES 82–87 in Revision of Charaea (Coleoptera: Chrysomelidae: Galerucinae) from Taiwan
No full textFIGURES 82–87. Habitus of Charaea. 82—Ch. sasajii (male, 3.2 mm); 83—Ch. shirozui (male, 3.6 mm); 84—Ch. taiwanum (male, 4.9 mm); 85—Ch. houjayi sp. nov. (paratype, male, 4.2 mm); 86—Ch. maxbarclayi sp. nov. (holotype, male, 5.1 mm); 87—Ch. haruoi sp. nov. (paratype, male, 4.0 mm).Published as part of Bezděk, Jan & Lee, Chi-Feng, 2014, Revision of Charaea (Coleoptera: Chrysomelidae: Galerucinae) from Taiwan, pp. 1-39 in Zootaxa 3861 (1) on page 26, DOI: 10.11646/zootaxa.3861.1.1, http://zenodo.org/record/28707
Measuring the chi(1) torsion angle in protein by CH-CH cross-correlated relaxation: A new resolution-optimised experiment
Full text linkHere we introduce an experiment with high sensitivity and resolution for the measurement of CH-CH dipolar-dipolar cross-correlated relaxation rates (CCRR) in protein side-chains. The new methodology aims to the determination of structural and dynamical parameters around the torsion angle chi(1) by measuring C(alpha)H(alpha)-C(beta)H(beta) cross-correlated relaxation rates. The method is validated on the protein ubiquitin: the chi(1) angles determined from the CCRR data are compared with the chi(1) angles of a previously determined NMR structure. The agreement between the two data sets is excellent for most residues. The few discrepancies that were found between the CCR-derived chi(1) angles and the angles of the previously determined NMR structure could be explained by taking internal motion into account. The new methodology represents a very powerful tool to determine both structure and dynamics of protein side-chains in only one experiment.</p
A new family of homoleptic Ir(III) complexes: Tris-pyridyl azolate derivatives with dual phosphorescence
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Comparison of the activation of potassium current by adenosine in rat, guinea pig and human a trial myocytes.
No full textHepatocyte growth factor gene therapy prevents radiation-induced liver damage. World Journal of Gastroenterology
No full textOn the Role of Materials Experience for Novel Interactions with Digital Representations of Historical Pop-up and Movable Books
No full textDirect interaction with cultural heritage (CH) artefacts is frequently unavailable to visitors, offering an opportunity for HCI designers to explore integrating material aspects into digitally-mediated encounters with CH artefacts. We argue that a thorough understanding of the material experiences of CH artefacts can open a novel design space, enabling engaging and meaningful interactions with digital representations. Capitalising on this potential, we present a user study where we systematically explore the material experiences of historic pop-up and movable books. Our analysis identifies five key material qualities to inspire augmentation: fold-ability, slide-ability, tear-ability, age-ability, and print-ability. Highlighting how these material qualities can inspire novel interactions with their digital representations, we present two extended-reality (XR) prototypes of a CH book. With our work, we present HCI designers with a novel approach on designing CH experiences, firmly rooted in materiality, challenging the prevalent paradigms of 'technology-driven' or 'as-realistic-as-possible' sensory experiences often found in CH-HCI.Mechatronic DesignHuman-Centred Artificial IntelligenceMaterials and ManufacturingEmerging Material
Selective reaction of camphor-derived exo-formyl [2.2.1]bicyclic carbinol with alkyl primary amines: application to the preparation of new chiral catalysts for asymmetric reduction of aryl ketones
No full text[[abstract]]Reaction of camphor-derived exo-formyl [2.2.1]bicyclic carbinol with various alkyl primary amines gave regio- and stereo-specific [3.2.1]bicyclic alpha-amino ketones. A detailed mechanism of the reaction was discussed. This reaction was further applied to the preparation of some camphor-derived oxazaborolidines, one of which proved to be an efficient chiral catalyst for the asymmetric borane reduction of prochiral aryl ketones at room temperature. (C) 2010 Elsevier Ltd. All rights reserved.[[note]]SC
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