8,621 research outputs found
Uso de indicadores de desempenho como auxílio nos estudos de eficiência energética em sistemas de abastecimento de água.
No full textSC author and illustrator Kate Salley Palmer signing book
No full textPhotograph of SC author and illustrator Kate Salley Palmer signing boo
Book signing by SC author and illustrator Kate Salley Palmer
No full textPhotograph of Book signing by SC author and illustrator Kate Salley Palme
HIFU 治疗患有肝硬化的原发性肝癌病人
No full textHepatocellular carcinoma (HCC) is one of the commonest cancers in Asia. However, only a small amount of patients is eligible for surgical intervention upon diagnosis. Treatment planning for patients with HCC remains a great challenge to most clinician. In Asia, most of the HCC patients are hepatitis B carrier. The bad combination of liver cancer and hepatitis B related cirrhosis make liver resection impossible in most of the patients.1 Radiofrequency ablation (RFA) is one of the very effective and simple treatment methods for HCC which can achieve survival similar to liver resesction for HCC smaller than 2cm. However, RFA may not be well tolerated in patients with cirrhosis and severe complication may follow after prolonged ablation.2 Transarterial choemoembolization (TACE) is a widely used treatment option for unresectable HCC and its effect has been shown to be better by best symptomatic treatment by randomised controlled studies.3 However, the survival outcome of TACE is not very appealing as the 2 year survival is around 30%. High intensity focused ultrasound (HIFU) is a totally non invasive ablation treatment modality. 4. Our center started offering HIFU treatment in 2006 as a non-invasive mode of surgical ablation for patients who could not tolerate liver resection because of poor liver reserve.5. Our initial results showed that the complete ablation rate with single ablation was 89.2%.6. Up to date, we have performed more than 200 cases of HIFU ablation to treat HCC and no postoperative liver failure has been recorded. HIFU ablation was safely performed in the present case even though the patient had thrombocytopenia. The unique needleless design of the HIFU system makes HIFU ablation superior to RFA, for needle penetration may induce hemorrhage from a hypervascular tumor in a patient with coagulopathy and low platelet count. Furthermore, without needle
puncture, there is no risk of direct tumor seeding to the surrounding major vessels. 4,7 In conclusion, HIFU ablation is a potentially curative measure which seems to be safe and effective for patients with unresectable HCC.
References
1. Cheung TT, Ng KK, Chok KS, Chan SC, Poon RT, Lo CM, Fan ST. Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: prognosis and outcomes. World J Gastroenterol 201 O; 16:3056-3062.
2. Cheung TT, Ng KK, Poon RT, Fan ST. Tolerance of radiofrequency ablation by patients of hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 2009; 16:655-660.
3. Lo CM, Ngan H, Tso WK, Liu CL, Lam CM, Poon RT, Fan ST, Wong J. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002; 35: 1164-1171.
4. Cheung TT, Chok KS, Lo RC, Sharr WW, Chan SC, Poon RT, Fan ST, Lo CM. High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation. Hepatobiliary Pancreat Dis Int 2012;11:542-544.
5. Ng KK, Poon RT, Chan SC, Chok KS, Cheung TT, Tung H, Chu F, Tso WK, Yu WC, Lo CM, Fan ST. High-intensity focused ultrasound for hepatocellular carcinoma: a single-center experience. Ann Surg 2011; 253:981-987.
6. Cheung TT, Fan ST, Chu FS, Jenkins CR, Chok KS, Tsang SH, Dai WC, Chan AC, Chan SC, Yau TC, Poon RT, Lo CM. Survival analysis of high-intensity focused ultrasound ablation in patients with small hepatocellular carcinoma. HPB (Oxford) 2012.
7. Cheung TT, Poon RT, Yau T, Tsang OS, Lo CM, Fan ST. High-intensity focused ultrasound as a treatment for colorectal liver metastasis in difficult position. Int J Colorectal Dis 2012; 27:987-988
Incidence and Demographics of Nasopharyngeal Carcinoma in Cheung Chau Island of Hong Kong—A Distinct Geographical Area With Minimal Residential Mobility and Restricted Public Healthcare Referral Network
No full textBackground:
Nasopharyngeal carcinoma (NPC) is endemic in Hong Kong with a skewed geographical and ethnic distribution. We performed an epidemiological study of NPC in Cheung Chau Island, a fishing village with very minimal residential mobility, and compared its demographics and survival with the rest of Hong Kong.
Methods:
NPC data in Cheung Chau and non–Cheung Chau residents between 2006 and 2017 treated in our tertiary center were collected. The incidence, stage distribution, and mortality of Cheung Chau NPC residents were compared with those of their counterparts in the whole Hong Kong obtained from the Hong Kong Cancer Registry. Propensity score matching (PSM) was performed between Cheung Chau and non–Cheung Chau cases in a 1:4 ratio. Overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS) were compared between these two cohorts by product limit estimation and log-rank tests.
Results:
Sixty-one patients residing in Cheung Chau were identified between 2006 and 2017. There was a significantly higher NPC incidence (P < .001) but an insignificant difference in the mortality rate in Cheung Chau compared to the whole Hong Kong data. After PSM with 237 non–Cheung Chau patients, the Cheung Chau cohort revealed a stronger NPC family history (P < .001). However, there were no significant differences in OS (P = .170), PFS (P = .053), and CSS (P = .160) between these two cohorts.
Conclusion:
Our results revealed that Cheung Chau had a higher NPC incidence but similar survival outcomes compared to the whole of Hong Kong. Further prospective studies are warranted to verify this finding and to explore the possible underlying mechanisms.published_or_final_versio
High-resolution clean-sc
No full textIn this paper a high-resolution extension of CLEAN-SC is proposed: HR-CLEAN-SC. Where CLEAN-SC uses peak sources in “dirty maps” to define so-called source components, HR-CLEAN-SC takes advantage of the fact that source components can likewise be derived from points at some distance from the peak, as long as these “source markers” are on the main lobe of the Point Spread Function (PSF). This is very useful when sources are closely spaced together, such that their PSFs interfere. Then, alternative markers can be sought in which the relative influence by PSFs of other source positions is minimised. For those markers the source components better agree with the actual sources, which allows for better estimation of their locations and strengths. This paper outlines the theory needed to understand this approach and discusses applications to 2D and 3D microphone array simulations with closely spaced sources
SC author and illustrator Kate Salley Palmer talking to event attendees
No full textPhotograph of SC author and illustrator Kate Salley Palmer talking to Rita Lewi
Ca-modified Al–Mg–Sc alloy with high strength at elevated temperatures due to a hierarchical microstructure
No full textAl-Mg alloys are normally prone to lose part of their yield and tensile strength at high temperatures due to insufficient thermal stability of the microstructure. Here, we present a Ca-modified Al–Mg–Sc alloy demonstrating high strength at elevated temperatures. The microstructure contains Al4Ca phases distributed as a network along the grain boundary and Al3(Sc,Zr) nano-particles dispersed within the grains. The microstructure evolution and age-hardening analysis indicate that the combination of an Al4Ca network and Sc-rich nano-particles leads to excellent thermal stability even upon aging at 300 °C. The tensile strength of the alloy for temperatures up to 250 °C is significantly improved by an aging treatment and is comparable with the commercial heat-resistant aluminum alloys, i.e., A356 and A319. At a high temperature of 300 °C, the tensile strength is superior to the above-mentioned commercial alloys, even more so when expressed as the specific strength due to the low density of Ca-modified Al–Mg–Sc alloy. The excellent high-temperature strength results from a synergistic effect of solid solution strengthening, grain boundary strengthening and nanoparticle order strengthening.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Novel Aerospace Material
Análise de perdas reais em um setor do sistema de abastecimento de água no município de Capinzal - SC
No full textSC-Square: Overview to 2021.
No full textThis extended abstract was written to accompany an invited talk at the 2021 SC-Square Workshop, where the author was asked to give an overview of SC-Square progress to date. The author first reminds the reader of the definition of SC-Square, then briefly outlines some of the history, before picking out some (personal) scientific highlights
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