1,720,962 research outputs found
Procoagulant cellular activity (PCA) in the classification of acute leukemia.
No full textThe procoagulant cellular activity (PCA) of leukemic cells was evaluated, before and after endotoxin stimulation, in 38 patients with acute leukemia at presentation subdivided according to the FAB classification. In the M4 and M5 subgroups the stimulated leukemic cells showed a significant increase in the production of PCA compared with freshly isolated cells. No evident PCA was documented in M1 and M2 AML as well as in the majority of acute lymphoid leukemias tested, both before and after endotoxin stimulation. The myeloid and lymphoid leukemic cells appear to behave similarly to normal leucocytes, within which only monocyte/macrophages are capable of producing PCA following endotoxin stimulation. These findings suggest that in human leukemic cells the endotoxin-induced production of PCA may be considered a indicator of monocyte/macrophage differentiation and thus represent a valuable diagnostic tool in the classification of acute leukemias
Procoagulant cellular activity and disseminated intravascular coagulation in acute non-lymphoid leukaemia
No full textHygienic surveillance in swimming pools: Assessment of the water quality in Bologna facilities in the period 2010-2012
No full textIn the three-year period 2010-2012, 80 public swimming facilities in the metropolitan area of Bologna (Emilia Romagna Region, Italy), including 144 pools (69 indoor, 75 outdoor), were monitored to assess the microbiological and chemical water quality, after about ten years of implementing the new Italian guidance which introduced the principles of internal safety plans in the surveillance of swimming pools. According to the Italian guidance, water samples were collected from supply water (370 samples), pool water (645), and recirculating water entering the pool (307). The samples of supply water always conformed to the microbiological limits for drinking water. The pool water did not conform to the Italian legal requirements in around 16% of indoor pools and 25% of outdoor pools. In 65% of non-compliant samples, only one parameter exceeded the required standards. The microorganisms of faecal origin were isolated very rarely (Enterococci in less than 2% of samples) and pH and residual chlorine showed good compliance in pool water, implying an efficient management of the internal control. The inlet water exceeded the required standards in about 36% and 50% of samples, respectively in indoor and outdoor pools. However, 83.6% of the corresponding samples of pool water met the required limits. The microbiological incongruities were prevalently due to high levels of total heterotrophic counts (THCs) and Pseudomonas aeruginosa, and were indicative of bacterial colonization of the filters. The sampling of inlet water can thus be indicated as a critical control point for checking the correct functioning of the filters. The non-conformity of samples led to pool closure only in 1.5% of cases. In the other cases, the operators were officially invited to perform the corrective measures previously established in the plan of risk assessment. On the whole, the approach based on internal safety plans produced satisfactory results in terms of pool water quality, demonstrating the effective working of the internal system of analysis and management of risks
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Depressed fibrinolysis in patients with acute leukaemia.
No full textThe fibrinolytic system was studied in 46 patients with acute leukaemia at diagnosis. Untreated patients (with the sole exception of the M3 subgroup) showed an inhibition of fibrinolytic activity, measured by the euglobulin lysis time and area. This inhibition was accompanied by reduced t-PA antigen and t-PA inhibitor activity. No correlation was found between the above-mentioned fibrinolytic parameters and the biochemical haematological values considered, nor with clinical and/or laboratory features of DIC, fever, liver failure. The decrease in immunological plasminogen and functional alpha 2-antiplasmin, showed a significant correlation with the presence of clinical and/or laboratory signs of DIC, as diagnosed on the basis of concomitant increase in fibrin monomers, plasmatic fibrinopeptide A and serum FDP
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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