67 research outputs found
Global extinction strain rate experiments of single large hydrocarbon fuels
No full textIncludes bibliographical references.An experimental validation study of the flame extinction characteristics of large hydrocarbon fuels is carried out. A counterflow flame burner combined with a liquid fuel vaporization system is utilized at a reduced pressure of 0.84 atm to measure the diffusion flame global extinction strain rate of liquid fuels as a function of fuel dilution. A numerical study is also employed using CHEMKIN to calculate the global extinction strain rate of hydrocarbon fuels, including n-heptane, n-decane, and toluene. Flame extinction measurements of the blended fuels are compared to global flame extinction predictions using a previously published radical index methodology
Implementation of VIB (Virtual Internal Bond) Model in Nanomaterial by Using Finite Element Approach
No full text
The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network
Get PDFThe small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi–ER (endoplasmic reticulum) fusion in mammalian cells, akin to the well-characterized fungal toxin BFA (brefeldin A). It has also been reported that Exo2 does not affect the integrity of the TGN (trans-Golgi network), or the direct retrograde trafficking of the glycolipid-binding cholera toxin from the TGN to the ER lumen. We have examined the effects of BFA and Exo2, and found that both compounds are indistinguishable in their inhibition of anterograde transport and that both reagents significantly disrupt the morphology of the TGN in HeLa and in BS-C-1 cells. However, Exo2, unlike BFA, does not induce tubulation and merging of the TGN and endosomal compartments. Furthermore, and in contrast with its effects on cholera toxin, Exo2 significantly perturbs the delivery of Shiga toxin to the ER. Together, these results suggest that the likely target(s) of Exo2 operate at the level of the TGN, the Golgi and a subset of early endosomes, and thus Exo2 provides a more selective tool than BFA for examining membrane trafficking in mammalian cells
A novel individual reconstruction of a medial orbital wall blow-out fracture using a bone graft molded intraoperatively using a 3-D model: a case report
No full textAbstractThis report describes the surgical reconstruction of a traumatic medial orbital wall blow-out fracture using an autologous calvarial bone graft modeled intraoperatively using a three-dimensional (3-D) fused deposition model of the fracture defect. Previous case reports have demonstrated the use of 3-D models in planning the surgical approach, selecting and fashioning the desired implant in the perioperative period, and even using models with sterile coverings intraoperatively to mold synthetic implants. This is an individually unique application of 3-D printing for the surgical repair of pure medical wall blow-out fracture
Impact of Fixed Orthodontic Appliances on Blood Count and High-Sensitivity C-Reactive Protein Levels
No full textBackground:
Fixed orthodontic appliances are widely used in dental practice to correct malocclusions and improving oral health. However, their impact on systemic inflammation and hematological parameters remains under-explored.
Materials and Methods:
A cohort of 60 patients, aged 12 –30 years, undergoing fixed orthodontic treatment, were enrolled in the study. Blood samples were collected at baseline, 1 month, and 6 months post-appliance placement. Hematological parameters, including white blood cell (WBC) count, red blood cell (RBC) count, hemoglobin levels, and hs-CRP levels, were measured using standard laboratory techniques. A statistical analysis was performed to determine significant changes over time.
Results:
At 1-month post-appliance placement, a significant increase in WBC count (mean increase of 12%) and hs-CRP levels (mean increase of 18%) was observed compared to baseline (P 0.05).
Conclusion:
The use of fixed orthodontic appliances induces a transient inflammatory response, as evidenced by elevated WBC count and hs-CRP levels within the first month of treatment
Synthesis and properties of high velocity oxy-fuel sprayed FeCoCrNi2Al high entropy alloy coating
No full textThe present study aims to develop dense FeCoCrNi2Al high entropy alloy (HEA) coating of thickness ≅ 200 μm by high velocity oxy-fuel (HVOF) process. Studies on the microstructure and mechanical properties like microhardness, erosion resistance of the HVOF coated FeCoCrNi2Al HEA has not been reported by any investigator. An adherent coating has been deposited displaying a lamellar microstructure. The X-ray diffractogram of the coating revealed the formation of a major FCC and a minor BCC phase with small amount of oxide. The oxide phase was confirmed to be Al2O3 using Raman spectroscopy. The microhardness of the coating is found to be 600 ± 30 VHN with no crack formation upto a load of 1 kgf. The erosion resistance of the HEA coated steel was evaluated upto a temperature of 800 °C. The coating displays good erosion resistance and the depth of penetration of the erodent was well within the coating thickness with no delamination of the coating, thereby making it suitable for high temperature applications
ANALYTICAL METHOD EVELOPMENT AND VALIDATION FOR ANTI ASTHAMATIC DRUG OXYMETAZOLINE HYDROCHLORIDE IN NASAL SPRAY FORMULATIONS BY RP-HPLC
Get PDFA new, simple, accurate and economic reverse-phase HPLC method has been developed for quantification of Oxymetazoline Hydrochloride in nasal spray formulations. This developed method has been validated according to International Conference on Harmonization (ICH) guideline with respect to system suitability, specificity, precision, linearity, accuracy, and robustness. An isocratic condition of mobile phase Phosphate buffer (pH 3.0): Acetonitrile in a ratio of 60:40, v/v at a flow rate of 1.0 mL/minute over RP C18 (octadecylsilane (ODS), 250 × 4.6 mm, 5 µm, ECLIPSE X DB C-18) column at ambient temperature was maintained. This method is specific and showed excellent linear response with correlation coefficient (R2) values of 0.999, which was within the limit of correlation coefficient (R2 0.995). A simple and accurate reversed-phase HPLC method for the analysis of Oxymetazoline Hydrochloride in nasal spray formulations was developed and validated successfully
Effect of endothermic reactions on the global extinction strain rate of large hydrocarbon fuels
Get PDF2018 Fall.Includes bibliographical references.When a hydrocarbon fuel is used as a coolant, the extreme environment can have a significant impact on the fuel composition. Heat exchange occurs through phase change, sensible heat extraction, and endothermic reactions experienced by the liquid fuel. From previous studies it has been demonstrated that the fuel composition changes significantly as well as the fuel properties as a result of the endothermic reactions. To investigate the effect of endothermic reactions on the fundamental flame behavior we have developed a counterflow flame burner that can measure the flame extinction strain rate of a thermally stressed fuel. The counterflow flame burner is coupled with a high-pressure reactor, capable of exposing the fuel to extreme conditions of 170 atm and 650 °C. Flame robustness is quantified by measuring the flame extinction strain rate. n-heptane is studied as a first attempt to understand the role of the endothermic reactions on the combustion and flame behavior of a liquid rocket propellant fuel. Modeling of the reactor and the counterflow flame is carried out using CHEMKIN. The flame extinction strain rate of the reacted n-heptane is compared with the unreacted n-heptane flame, thus allowing us to determine and extrapolate the role of endothermic reactions on the combustion behavior of jet and rocket fuels
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