124,833 research outputs found
Pneumocystis jirovecii dihydropteroate synthase gene mutations in a group of HIV-negative immunocompromised patients with Pneumocystis pneumonia
No full textThe purpose of this study was to investigate dihydropteroate synthase (DHPS) mutations and their clinical context in non-HIV-infected patients with Pneumocystis pneumonia (PCP). DHPS genes in respiratory samples collected from HIV-negative patients with PCP presented between January 2008 and April 2011 were amplified by polymerase chain reaction (PCR) and sequenced. Basic clinical data from the medical records of the patients were also reviewed. The most common point mutations, which result in Thr55Ala and Pro57Ser amino acid Substitutions, were not detected in the Pneumocystis jirovecii sampled from the HIV-negative patients. Two other point mutations, which result in nonsynonymous mutation, Asp90Asn and Glu98Lys, were identified in P. jirovecii from two patients. Among the patients, the levels of lactate dehydrogenase (LDH), C-reactive protein (CRP) and plasma (1-3) beta-D-glucan were elevated in 75, 92.31 and 42.86% of patients, respectively. The percentage of circulating lymphocytes was significantly lower in non-survivors than in survivors [4.2%, interquartile range (IQR) 2.4-5.85 versus 10.1%, IQR 5.65-23.4; P=0.0191. The neutrophil proportion in bronchoalveolar lavage fluid (BALF) was significantly higher in non-survivors than in survivors (49.78 +/- 27.67 versus 21.33 +/- 15.03%; P=0.047). Thirteen patients had received adjunctive corticosteroids (1 mg/kg/day prednisone equivalent) and nine (69.23%) of them eventually experienced treatment failure. No common DHPS gene mutations of P. jirovecii were detected in the HIV-negative PCP patients. However, other mutations did exist, the significance of which remains to be further identified. The elevation of neutrophil counts in BALF and reduction of the number of lymphocytes in peripheral blood may be associated with poor outcome. The efficacy of adjunctive steroid therapy in HIV-negative patients with P. jirovecii infection requires further investigation.Medicine, Research & ExperimentalSCI(E)[email protected]
Preliminary Study of CPET in Patients With Central Airway Obstruction
No full textCPCI-S(ISTP)41116A-1116A15
La nueva emigración española. Lo que sabemos y lo que no
No full textLa crisis económica que azota el país desde hace ya seis años no podía dejar de
tener su reflejo demográfico. La población residente en España se ha reducido
en 2013 en más de 50.000 personas. Es la primera vez que esto ocurre desde
que se disponen estadísticas comparables (Cifras de Población, INE 2013). La
inversión del ciclo migratorio tiene mucho que ver en ello. Tras el boom inmigratorio
iniciado en el año 2000 y que supuso un crecimiento medio de 720.000
habitantes en el período 2002-2008, las entradas de extranjeros se fueron ralentizando
desde 2009, a la vez que los flujos de salida se intensificaban. Dichas
salidas han sido protagonizadas por ciudadanos extranjeros, pero el número de
los españoles que se marchan del país no ha dejado de crecer desde 2008 y, en
especial, desde 2011 (Gráfico 1).
De hecho, un 48% de los españoles decían estar dispuestos a trasladarse
a vivir a otro país en el Barómetro del CIS de febrero de 2012, frente a un 30%
de los suecos o el 35% de los alemanes en encuestas similares. Y un 17% confesaba
haber pensado realmente en esa posibilidad en los últimos doce meses.
Las historias de españoles que deciden emprender el camino de la emigración
inundan reportajes periodísticos y programas televisivos desde hace meses. Y
la preocupación por la posible ‘fuga de cerebros’ y sus consecuencias a medio
y largo plazo sobre la economía y el desarrollo de nuestro país son innegables.
En este documento trataremos de poner algo de orden en las cifras, combinando
y contrastando la información que ofrecen nuestras fuentes con las procedentes
de algunos de los destinos principales de la nueva emigración española.
Situaremos la dinámica migratoria española en el contexto de los movimientos
migratorios intra-UE durante la crisis para apreciar mejor su importancia cuantitativa
y cualitativa. Además examinaremos cómo se está modificando el perfil
del emigrante español desde que empezó la crisis y si se trata de una migración
permanente o de corto plazo, en función de las cifras de retorno disponibles.Peer reviewe
QUANTUM-THEORY OF PLASMONS IN LATERAL MULTIWIRE SUPERLATTICES - INTRASUBBAND PLASMONS AND THEIR COUPLING TO INTERSUBBAND PLASMONS
No full textWe analyze intrasubband plasmons in lateral multiwire superlattices and study their coupling to intersubband plasmons. We find that the local approximation is equivalent to neglecting the umklapp contributions to the plasmon energy. While this approximation fails completely for intersubband plasmons, it is reasonable for intrasubband plasmons in the long-wavelength limit. In common with intersubband plasmons, an approximate sum rule exists for intrasubband plasmons, but unlike the case for intersubband plasmons, here it is more precise because it tends to be independent of the details of the confining potential. It is predicted that in a system with n populated subbands, we should observe experimentally only one intrasubband plasmon mode. For zero wave vector along the superlattice direction, intrasubband plasmons only couple to even-parity intersubband plasmons. The coupling of intrasubband plasmons to the dominant intersubband plasmons and other odd-parity intersubband plasmons is very weak in general. Experiments are proposed to verify the importance of Coulomb coupling between wires.Physics, Condensed MatterSCI(E)33ARTICLE97127-71354
Gender and the politics of the gaze in Bronte's Wuthering Heights
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Letras/Inglês e Literatura Correspondente, Florianópolis, 2009.O objetivo deste estudo é apresentar uma análise de como a imagem de Catherine é moldada pelo olhar masculino, como ela enfrenta os três tipos de olhar - o olhar dos personagens, o olhar do leitor, e o olhar do autor - e finalmente, se o olhar masculino é interrompido. O parâmetro teórico desta análise, o conceito do olhar masculino, é teorizado por Laura Mulvey no artigo "Prazer Visual e Cinema Narrativo" (1975) o qual critica a relação entre o olhar masculino e a imagem feminina do prazer visual moldado pela sociedade patriarcal. Através da crítica de Mulvey do prazer visual generizado em filmes, que pertence ao contexto do cinema clássico de Hollywood, articulo sua teoria em relação ao romance Wuthering Heights de Emily Brontë para examinar a dinâmica do olhar masculino em relação à personagem feminina Catherine. Este estudo teve também por objetivo analisar o quanto o paradigma teórico de Mulvey produzido para cinema poderia ser aplicado especificamente em um texto literário escrito no século XIX.The objective of this thesis is to present an analysis of whether Catherine's image has been shaped by the male gaze, how she contends with the three looks of the male gaze - the look of the characters, the look of the reader, and the look of the author - and finally, how the male gaze is broken. The theoretical parameter of this analysis, the concept of the male gaze, is theorized by Laura Mulvey in the article "Visual Pleasure and Narrative Cinema" (1975) which critiques the relation between the male gaze and the female image within the patriarchal molding of visual pleasure. Borrowing Mulvey's critique of the gendering of visual pleasure in films, which pertains to the context of classical Hollywood cinema, I have articulated her theory in relation to Emily Brontë's Wuthering Heights, to examine the dynamics of the male gaze regarding the female character, Catherine. This study also aimed at examing the extent to which Mulvey's theoretical paradigm produced for cinema could be articulated specifically in relation to a literary text written in the nineteenth century
Calciumcarbonaatfabriek
No full textDocument(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science
Identification of Velcro rales based on Hilbert-Huang transform
No full textVelcro rales, as a kind of crackles, are relatively specific for lung fibrosis and usually the first clinical clue of interstitial lung disease (ILD). We proposed an automatic analytic tool based on Hilbert-Huang transform (HHT) for the computerized identification of Velcro rales. In particular, HHT was utilized to extract the energy weight in various frequency bands (EWFB) of crackles and to calculate the portion of crackles during late inspiration. Support vector machine (SVM) based on the HHT-derived measures was used to differentiate Velcro rales from other crackles. We found that there were significant differences in the extracted parameters between Velcro rales and other crackles, including EW75-200, EW500-1000 and the proportion of crackles that appeared during the late inspiration. The discrimination results obtained from SVM achieved a concordance rate up to 92.20% +/- 1.80% as confirmed by the diagnosis from experienced physicians. For practical purpose, the proposed approach may have potential applications to improve the sensitivity and accuracy of auscultation and conduct automatic ILD diagnose system. (C) 2014 Elsevier B.V. All rights reserved.Physics, MultidisciplinarySCI(E)[email protected]; [email protected]
Hou Renzhi, 1911-2013 Obituary
No full texthttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330909100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701GeographyHistory Of Social [email protected]
Carta sobre un cajoncito que contiene prendas indígenas, 1776 enero 20
No full textCarta a Junípero Serra en la que se reconoce que aún no se ha recibido un cajoncito con prendas de indígenas recién descubiertos. El autor asegura a Serra que le avisará cuando lo reciba y expresa su gratitud por la fina memoria. —— Letter to Junípero Serra acknowledging that they have not yet received a small box containing garments of newly encountered Indigenous people. The author assures Serra that they will notify them upon receipt and expresses gratitude for the thoughtful remembrance. 1 f. (2 p.
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