63,407 research outputs found
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Letter from Carl Hayden to Henry F. Ashurst
No full textLetter describing three enclosures, a letter from F. M. Gold, Carl T. Hayden's reply to Gold's letter, and a copy of a bill introduced by Cameron
Letter from A. F. Potter to Carl Hayden
No full textLetter from A. F. Potter to Carl T. Hayden describing John H. Page's request to build a railway for the Canyon Copper Company as "impractical"
Da cheng wu liang shou jing 大 乘 無 量 夀 經 [trad. de Fa cheng 法 成].
No full textDa cheng wu liang shou jing 大 乘 無 量 壽 經Wu liang shou zong yao jing 無 量 壽 宗 要 經Numérisation effectuée à partir d'un document original.Complet. Menues variantes par rapport à T . 936, vol. 19, pp. 82 a-84 c. Titre final : Fo shuo wu liang shou zong yao jing 佛 說 無 量 夀 宗 要 經. A gauche et à plusieurs cm du titre final, le nom du copiste en petits car. : Tian Guang tan 田 廣 談. 33 autres copies du même texte portent cette signature. Cf. SGSR , p. 392, n°s 1688-1721. Écr. kai à tendance xing. Encre foncée. Nombreux alinéas. 138 col., 28 à 29 col. par f., 32 à 37 car. par col. Marges tracées sup. 1,9 à 2 cm, inf. 1,1 à 1,7 cm. Réglures 1,5 cm
The application of Jing-Jia-Ji and Hua-Tuo-Jia-Ji in small animals. Proceeding of the 34 annual international congress on veterinary acupuncture.
No full textA 20-year database of MCSs in eastern China
No full textThis dataset contains the mesoscale convective systems (MCSs) over eastern China (20-42N, 95-125E) during the eight monsoon stages from 2001 to 2020.
The zipped data are in netCDF format, each contains the brightness temperature (lon, lat, time) of an MCS event. Note that
The time attribute shows "minutes since 2001-01-01 00:00"
The lon, lat attributes are in degrees at the 4-km resolution
For inquiries or potential collaborations, feel free to contact Dr. Tat Fan Cheng ([email protected]) or Prof. Mengqian Lu ([email protected]).
If you find our dataset/analyses useful, please cite our recent paper (Thank you!).
Cheng, T. F., Dong, Q., Dai, L., & Lu, M.* (2022). A Dual Regime of Mesoscale Convective Systems in the East Asian Monsoon Annual Cycle. Journal of Geophysical Research: Atmospheres, 127, e2022JD036523. https://doi.org/10.1029/2022JD03652
Usefulness of (Ti)-T-201 Spect/Ct Relative to F-18-Fdg Pet/Ct in Detecting Recurrent Skull Base Nasopharyngeal Carcinoma
No full textBackground. This study was designed to compare (TI)-T-201 single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose (F- 18-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC). Methods . Twenty-seven patients were recruited. Both (TI)-T-201 SPECT/CT and F-18-FDG PET/CT for each patient were performed at least 4 months later after initial therapy. Results. The sensitivity and specificity for (TI)-T-201 SPECT/CT were 66 .7% and 100%, and those for F- 18-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/ background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios. Conclusion. (TI)-T-201 SPECT/ CT is as effective as F-18-FDG PET/CT in detecting recurrent NPC. For intracranal recurrence, (TI)-T-201 SPECT, because of its high intracranial lesion/background ratio, is probably better than F-18-FDG PET
Elaboration on Kwapien's theorem: Representing bounded mean zero functions f as coboundary f = g ◦ T − g
No full textIn [8] Kwapien proved that every mean zero function f ∈ L∞[0, 1] we can write as f = g ◦ T − g for some g ∈ L∞[0, 1] and some measure preserving transformation T of [0, 1]. However, as was discovered in [4] there is a gap in the proof for the case that f is not continuous. The aim of this bachelor thesis is filling in that gap in the proof. We first extend Kwapien’s proof for continuous functions to certain other measure spaces. Thereafter, we use the method of proof suggested by Kwapien, to proof the theorem for mean zero function f ∈ L∞[0, 1] for which λ(f−1({x})) = 0 for all x ∈ R. Using this result we then proof that every mean zero function f ∈ L∞[0, 1] can be written as a sum f =(g1 ◦ T1 − g1) + (g2 ◦ T2 − g2) where g1, g2 ∈ L∞[0, 1] and where T1, T2 are measure preserving transformations of [0, 1]. We finish this thesis with an application of Kwapien’s theorem in the study to singular traces Applied Mathematic
f(G,T) and its Cosmological Implications
Full text linkA coupled formulation of the Gauss-Bonnet invariant term G and the
energy momentum trace T term provide a modified f(G,T) gravity,
has been analyzed in this study. The functional form for the
f(G,T) gravity has been taken as f(G,T)=αT+ βGThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Oscillatory Periodic Solutions for Two Differential-Difference Equations Arising in Applications
Full text linkWe study the existence of oscillatory periodic solutions for two nonautonomous differential-difference equations which arise in a variety of applications with the following forms: ẋ(t)=-f(t,x(t-r)) and ẋ(t)=-f(t,x(t-s))-f(t,x(t-2s)), where f∈C(R×R,R) is odd with respect to x, and r,s>0 are two given constants. By using a symplectic transformation constructed by Cheng (2010) and a result in Hamiltonian systems, the existence of oscillatory periodic solutions of the above-mentioned equations is established
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