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    RIC-HSCT for MF/SS

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    Advanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS

    The MF+v algorithm.

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    A. Schematic of the algorithm. We begin by choosing initial values and . These values are used to drive a pair of LIF neurons for 20 seconds (biological time). The resulting membrane voltages are then fed into the MF Eq (8), which gives us firing rates for the next iteration. This is repeated until certain convergence criteria are met (see text). In the above, all dashed lines are modeled by Poisson processes. B. 500 training iterations of the MF+v. The means of every 100 iterations are indicated by green crosses, stability properties of which are quite evident. C. Comparison of network (black) and MF+v computed (red) firing rates.</p
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