33,439 research outputs found
Oral History Interview with Tsung-Mei Cheng
No full textTsung-Mei Cheng is an American health policy research analyst at Princeton University. Together with her husband, Uwe E. Reinhardt of Princeton University, Cheng provided critical advice to the Taiwanese government in establishing a single-payer national health insurance system in 1995. She has given numerous talks around the world on issues relating to health care and health policy, including the United States, China, Taiwan, Japan, countries in Southeast Asia, Europe, Mexico, and the Middle East. Cheng is a regular commentator in domestic and international news media on health care in China, Taiwan and the United States, as well as the recent COVID crisis. She was the lead witness in a 2014 U.S. Senate hearing on universal healthcare and appeared in “Sick Around the World,” a 2008 Frontline documentary by the Public Broadcasting Corporation.Soon, Wayne; Cheng, Tsung-Mei. (2025). Oral History Interview with Tsung-Mei Cheng. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/276486
The political role of the people's liberation army 1949-1973
Full text linkThis thesis is to study the political role of the People's Liberation Army from the approach of structure and function. The framework of the thesis consists of three major parts, first, the influence of Chinese traditional political culture on, and the formation of, the political role of the PL A; second, the influence of domestic political struggles and external military conflicts on the development of the political role of the PLA; and the third, the analysis of the transition of the PLA's political role from the structure and personnel arrangements of the CCPCC Within the above-mentioned three scopes, this thesis make a thorough discussion on the following: (1) The relationship between the structure of the PRC and the formation of the PLA's political role; (2) How has ideology influenced the army's political role; (3) What is Mao's viewpoint and his influence on the development of the army's political role; (4) What is the link between the army and the party, and how has this developed; (6) What accounts for the expansion of the PLA's political functions; (7) What is the influence of political factional struggles on the PLA's political role; (8) Is it political institution or military institution that controls the recruitment of the military elite; (9) What are the disparities between the military elite in handling international conflicts and what are their political considerations; (10) What is the Party's position in the army; (11) How have the Party’s important meetings and personnel arrangements influenced the rise and fall of the PLA's political role
Program Notes of Cheng-Hsin Kuo\ue2s Violin Recital
No full textThis report is the program notes of Cheng-Hsin Kuo\ue2s Violin Recital, which was performed at Chiang Kai-shek Chateau in National Sun Yat-sen University on December 9, 2019. The repertoires of the recital include Johann Sebastian Bach\ue2s Partita for Solo Violin in D Minor, BWV 1004: Chaconne, Niccol\uc3\ub2 Paganini\ue2s 24 Caprices for Solo Violin, Op. 1 No. 13, Johannes Brahms\ue2 Violin Sonata in G Major, Op. 78, and Henryk Wieniawski\ue2s Polonaise Brillante in A Major, Op. 21. The program notes will present the lives of the four composers, as well as the background and music styles of the four compositions, so that the performer can further understand the content of the works, and interpret them with more conviction
Comparison of Molecular Structures of Protofibrils and Mature Fibrils Formed by Residues 113-127 of Syrian Hamster Prion Protein
No full text類澱粉樣纖維 (amyloid fibril) 是由錯誤折疊之蛋白質聚集而成，傳染性海綿樣腦病變 (TSE) 即為類澱粉樣纖維或其先驅物造成的疾病之一。普昂蛋白 (Prion protein,PrP) 正是引發傳染性海綿樣腦病的主因，當有致病性的普昂蛋白 (PrPSc) 存在，會誘使其他正常的普昂蛋白 (PrPC) 轉變為致病性結構，PrPSc單體通過分子間氫鍵與凡德瓦力作用而聚集成類澱粉樣纖維沉積於患者腦中，傷害患者的神經系統。探討類澱粉樣纖維的分子結構對於了解其致病機制甚至是找出治療方法十分重要，但類澱粉樣纖維為不溶性的非晶型物質，難以用一般解析蛋白質分子結構的液態核磁共振與X光繞射偵測，所以目前固態核磁共振技術仍是分析類澱粉樣纖維結構的最佳方法。 在論文中我們針對敘利亞倉鼠普昂蛋白第113至127的胜肽片段(Ac-AGAAAAGAVVGGLGG-NH2, SHaPrP113-127)進行研究，探討胜肽在培養過程中的分子結構。我們利用ThT螢光吸收、穿透式電子顯微鏡以及原子力顯微鏡辨識纖維分子的生成與構形，發現SHaPrP113-127在純化後已具備纖維絲狀形貌，也具有ThT螢光吸收特性，其纖維寬度約12 nm，高度約1 nm，長度約100 nm，邊界並不明顯。經培養後的成熟纖維其寬度及高度與未培養者相似，唯長度略長，約300 nm，並且ThT螢光吸收較強，顯示其結構較為完整。接著利用固態核磁共振去偵測培養前後的分子結構，透過二級化學位移可以確定培養前後都是β-strand結構，同時可由13C線寬得知SHaPrP113-127纖維分子從115到120殘基位置結構較規則。實驗結果比較發現，培養之後的成熟纖維有明顯的steric zipper結構，未培養的樣品則沒有此特性。由實驗數據我們可以推測結構不完全的原纖絲(protofibril)應是形成單層β-sheet結構後，再以層與層之間side chain的疏水作用力形成zipper結構。配合紅外線光譜之鑑定，得到β-sheet是反向平行排列。最後以分子動態計算 (MD simulation)，得到SHaPrP113-127類澱粉樣纖維的分子結構模型。Amyloid fibrils are ordered aggregates of misfolded proteins, which associated with many neurodisorder diseases. Transmissible spongiform encephalopathy (TSE) is one of these fatal diseases. It is suggested that TSE is caused by the conversion of prion protein from its normal cellular form (cellular prion protein, PrPC) to the disease-specific form (scrapie prion protein, PrPSc).The presence of PrPSc will induce the misfolding of other PrPC to PrPSc, existing in the form of amyloid fibrils and damaging the nervous system of the victims. To elucidate the mechanism and pathways of fibril formation and to find the therapy, it is very important to analyze the molecular structure of amyloid fibrils. However, because amyloid fibrils are insoluble in most buffers and are non-crystalline, it is difficult to use conventional experimental techniques such as solution-state NMR or X-ray to obtain the detailed structure of amyloid fibrils. Solid state NMR spectroscopy is a unique method that can provide high-resolution, site-specific structural constraints for amyloid fibrils. In this thesis, we report the results of ThT fluorescence, TEM, AFM, FTIR, and solid-state NMR (SSNMR) data for protofibrils and mature fibrils formed by residues 113-127 of the Syrian hamster prion protein (SHaPrP113-127, Ac-AGAAAAGAVVGGLGG-NH2). We found that after purification, SHaPrP113-127 peptides have already had short fibrillar structure, and also an enhanced fluorescence upon binding to ThT. These properties confirm that the SHaPrP113-127 peptides right after purification are in protofibrillar state. After incubation, the length of the mature fibrils becomes longer and the intensity of the ThT fluorescence becomes significantly enhanced. The mature fibrils in general have a length over 300 nm, a width of 12 nm, and a height of 1 nm. From the chemical shift and the linewidth data obtained from SSNMR measurements, the β-sheet structure formed in both protofibrils and mature fibrils have significant ordered structure from the residue 115 to 120. Our data reveal that the molecular structure of mature fibrils adopts the motif of steric zipper, whereas, the structure of protofibrils dose not. From the FTIR spectra, the β-strands within each layer are anti-parallel. Consequently, a molecular model for the fibrils was constructed by molecular dynamics simulations incorporated with structural constraints obtained from solid-state NMR measurements. We suppose that the process of fibril formation takes the following pathway. First, monomeric SHaPrP113-127 molecules self-assemble into single layer that is predominated by anti-parallel β-sheet. After that, two layers mate tightly and form the steric zipper by the hydrophobic interaction of side chains.第一章 序論 1-1 類澱粉樣纖維 1-2 普昂蛋白簡介 4-3 普昂蛋白結構異變 7-4 偵測類澱粉樣纖維分子結構 12-4-1 紅外線光譜 13-4-2 圓二色光譜 15-4-3 固態核磁共振 17-5 研究動機 19-6 參考文獻 20二章 核磁共振基本原理 26-1 引言 26-2 核磁共振基本原理 26-2-1 核自旋（Nuclear spin） 26-2-2 自旋弛豫（Relaxation） 29-2-3 NMR訊號 33-2-4 NMR系統中的作用力 34-2-5 二維核磁共振光譜 39-3 固態核磁共振（Solid state NMR） 41-3-1 魔術角旋轉（Magic angle spinning, MAS） 42-3-2 去耦合 (Decoupling) 43-3-3交叉極化（Cross-polarization, CP） 44-3-4回耦（recoupling） 46-4 固態核磁共振對於偵測蛋白質二級結構的應用 48-5 小結 51-6 參考文獻 51三章、合成與鑑定 54-1 材料與儀器 54-1-1化學藥品 54-1-2 使用儀器型號一覽表 56-2 胜肽樣品的製備 57-2-1 固相胜肽合成 57-2-2 胜肽樣品的純化 62-2-3胜肽樣品的鑑定 63-3 SHaPrP113-127類澱粉樣蛋白纖維的備製 65-4 類澱粉樣蛋白纖維的鑑定 66-4-1 ThT（Thioflavin-T） 螢光吸收 67-4-2 穿透式電子顯微鏡 (TEM) 69-4-3 原子力顯微鏡 (AFM) 70-5 類澱粉樣纖維分子結構的鑑定 70-5-1 固態核磁共振 71-5-2 紅外光吸收光譜（FT-IR） 72-6 固態核磁共振光譜 72-6-1 13C-H交叉極化魔角旋轉光譜 72-6-2 fpRFDR-CT光譜 73-6-3 fpRFDR 2D 74-6-4 DARR (Dipolar assisted rotational resonance) 74-7 參考文獻： 75四章 實驗結果與討論 78-1 胜肽的純化與鑑定 78-2 類澱粉樣纖維分子的鑑定 80-2-1 穿透式電子顯微鏡 80-2-2 ThT螢光吸收 82-2-3 原子力顯微鏡 83-3 建構SHaPrP113-127形成類澱粉樣纖維的分子模型 85-3-1 13C-13C同核相關二維譜 86-3-2 Steric Zipper 91-3-3 FT-IR實驗結果93-3-4 SHaPrP113-127分子間結構（Intermolecular Structure）96-3-5分子模型之建構 105-4 與SHaPrP109-122以及HuPrP106-126之類澱粉樣纖維分子結構比較 110-5 參考文獻 112五章 總結與未來展望 115-1 論文總結 115-2 未來展望 11
sj-docx-1-wso-10.1177_17474930221079163 – Supplemental material for Syphilis and ischemic stroke: Old question revisited by a nationwide cohort study
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930221079163 for Syphilis and ischemic stroke: Old question revisited by a nationwide cohort study by Shu-Han Chang, Chih-Hsiang Kao, Chih-Hsin Hung, Mei-Chia Chou, Hei-Tung Yip, Yao-Min Hung, Renin Chang and James Cheng-Chung Wei in International Journal of Stroke</p
Work Fatigue in a Hospital Setting: The Experience at Cheng Hsin General Hospital
No full textWe aimed to investigate fatigue and its related factors in a medical professional population aged ≥30 years, as appraised by the implementation of an employee health screening program at Cheng Hsin General Hospital in Taipei, Taiwan. The study participants included a total of 2132 (400 males and 1732 females) healthy medical professionals enrolled in a teaching hospital who underwent physical verification in 2019. Demographic characteristics and fatigue information were collected. The overall prevalence of personal- and work-related fatigue in this study population was 41.4% and 39.1%, respectively. The prevalence of a high risk of work- or personal-related fatigue proved to be substantially greater (p-value for chi-square test <0.0001) than it was for a low or moderate risk of personal-related fatigue. Using multinominal logistic regression analysis, seniority and position were statistically significant in relation to a high risk of personal- and work-related fatigue. Personal- and work-related fatigue were found to be prevalent in physicians and nurses. Lower seniority was also related to severe personal- or work-related fatigue. Providing this population with controlled working environments and health improvements is important
Taiwan’s democratic progressive party and its mainland china policy
Full text linkTaiwan has successfully changed its political system from dictatorship into a democracy since the end of 1980s. Some people do not like 'Taiwan's democracy' -some candidates get elected by bribery in election, parliamentary fighting., but the majority of the Taiwanese people really enjoy their freedom in their homeland. They do know, at least, they have the right to oppose the government, no one would be shot by the national military force in a demonstration. The political systems are totally different between Taiwan and Mainland China, one is democracy, another is communism. Even the majority of the Taiwanese people are Chinese in ethnic origin, but their life experience are different over the past 50 years, it is difficult for any side to persuade the other side which one is better. Some Chinese Taiwanese people believe that they can have a better life, if their homeland—Taiwan can be really independent in the international community. Taiwan’s political opposition built Taiwan's first opposition party— Democratic Progressive Party (DPP) 13 years ago, and with the dream of establishing a new independent country on Taiwan. The establishment of the DPP is the result of the political opposition movement in Taiwan. Most of the members of the DPP have a strong Taiwanese identity, which is very different from the ruling KMT in Taiwan and the ruling CCP in China. The DPP gains more influence in Taiwan, the uncertainty across the Taiwan Straits increase at the same time. The DPP waited and saw between being the ruling party and establishing an independent country on Taiwan, finally it chose to complete the political aim of replacing the position of the KMT at present. The purpose of the study is to assess the DPP's policy-making in its Mainland China policy. I try to give a full picture of the policy-making process in the party. The most important factor in the formulation of the mainland China policy is the relationship between the factions within the DPP, therefore, I adopt the historical and document review approach on doing this study, and describe how the interaction between the factions worked and how they made the decisions on the policies? I found that the DPP will insist on its 'one Taiwan, one China' policy before becoming the ruling party in Taiwan. However, the DPP's insistence on the 'one China, one Taiwan' policy could bring conflicts across the Taiwan Straits and obstruct the possibility of replacing the ruling KMT's position. Hence the DPP tried to explain again the party's Taiwan independence platform, and to 'purify' the party’s ideology in order to achieve its present political aim. Because the cross-Straits relationship is still developing, the DPP's mainland policy would be affected by various factors across the Taiwan Straits. There is no final text of the DPP's mainland China policy at present. Therefore, I predict the future development of its China policy could tend in two ways. Firstly, if the cross-Straits exchanges increase, and Beijing reduces its hostility, the DPP's stand of 'one Taiwan, one China' will become more flexible, and it would keep on developing a more perfect China policy. Secondly, if the cross-Straits exchanges decrease, and Beijing increases the force of threatening to Taipei, the DPP's stand of 'one Taiwan, one China' policy will be more radical, even though it would not turn its back on the business affairs. At the end of this work, I suggest the DPP rethink its insistence on a Taiwanese independence position, this could not break Taiwan's isolation in international community, but could endanger Taiwan's security. As the factional fight has reduced the force of the DPP, to condense the powers of the party would be an important issue for the DPP
The politics of fashion: perceptions of power in female clothing and ornamentation as reflected in the sixteenth-century Chinese novel Jin Ping Mei
Full text linkThis thesis examines issues of female power and influence in sixteenth-century China focusing on how women and their roles were perceived in the changing social environment of the mid-late Ming dynasty. Using aspects of a New Historicist approach, information from contemporary literary and historical sources are analysed alongside each other. With its emphasis on the lives of women and preoccupation with the description of material objects, the late Ming novel Jin Ping Mei forms an important element in the thesis. China in the sixteenth century saw expanding urbanisation, the emergence of a new wealthy merchant class, increasing visibility of women and a questioning of traditional morality. Fashion consciousness, as one of the most conspicuous aspects of the new material culture, is a possible indicator of these trends. Traditional Western theories contend that fashion began in the particular context of Renaissance Europe. However, this study argues that a similar fashion awareness existed in China too, and was manifested in a competitive striving for social status, in this case specifically among women. In contrast to previous studies which downplayed the impact women had on defining traditional Chinese culture, this thesis demonstrates how women and their sartorial choices began to redefine the boundaries of material culture, influencing literati discourse which, in turn, re- influenced female behaviour
Refugee housing for Hong Kong
Full text linkThesis (M.Arch)--Massachusetts Institute of Technology, Dept. of Architecture, 1962.Includes bibliographical references (leaves 62-64).by Samuel Cheng-Mei Wang.M.Arc
Mei Nung Hakka Restaurant Attracting International Tourism by Combining Localization Strategy and International Accreditation
No full textRecently, Hakka culture is getting a high attention because of the promotion activities of Taiwanese local governments and the Hakka Affair Council of the Republic of China. "Hakka Food" has become a new favorite cuisine of gourmand. However, Hakka food is still categorized as home-cooking dishes and barely served in the high-end restaurant. The author is the owner of Mei Nung Hakka Restaurant and has run the restaurant many years in Kaohsiung. The mission of Mei Nung Hakka Restaurant is to pass on Hakka culture to future generations and to create a new brand of Mei Nung Hakka Food Restaurant that could stand alone in Taiwan and enter into the global market in the future.
The study was focusing on the investigation of "Localization" and "Glocalization" concepts to make effective strategies for the operation of Mei Nung Hakka Restaurant. We first studied the definition of these two strategies to figure out approaches for restaurant running. Secondly, we analyzed several cases of global corporations such as McDonald, Starbucks, 85\uc2\ubaC Daily Cafe and Ding Tai Feng restaurant to study the patterns of their success. Finally, we combined these strategies, outcomes of case studies, international accreditation of restaurant, and Hakka culture to design proper strategies for Mei Nung Hakka Restaurant's future operation
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