8,488 research outputs found
Hi-C_E8.5_mouse_hearts_WT-DKO
No full textHi-C with WT and U1U2-DKO E8.5 mouse hearts was performed. The NGS data are used for paper publication. The resourse is shared here for more researches.</p
Traceless solid-phase synthesis of cyclopenta[c]quinolines and cyclopenta[c]chromenes via hetero [6+3] cycloadditions of fulvene. A facile approach to the 11-heterosteroids framework
No full textMultilineage differentiation and characterization of the human fetal osteoblastic 1.19 cell line: a possible in vitro model of human mesenchymal progenitors
No full textHI-03 Cultivated Words of Chen Hongmou
Full text linkDuring the Qing dynasty, the Chinese Government appointed officials based on a man’s education and how he passed the imperial examinations. Chen Hongmou stands out among the many officials chosen during the eighteenth century.
Born October 10 1696 in Lingui, Guangxi, China, Chen spent his career as an official for several provinces. Based on his own experiences, Chen wrote texts on leadership and the duties of officials. He not only wrote to promote a system of good governance, he did so while espousing progressive ideals.
For example, he stated that women and “non Chinese” tribes should partake in the same education as enjoyed by Han men. Some of Chens ideals still resonate to present time. This poster will consider Chen Hongmou’s teachings to argue that his writings shed light on the Qing dynasties structure of culture and the problems it encountered. Chen’s ideals gave a new breath of life within the Qing dynasty and emphasized that provincial leaders should strive hard to be strong benefactors to their people.
His focus on furthering the well-being of everyone under his influence is shown when he advocates not only for his constituents with societal influence but also for minorities around him. This poster uses On The Duties Of An Official by Chen Hongmou as its primary source and a variety of secondary sources to contextualize the argument
Anomalous Energy Shift of Emission Spectra of ZnO Nanorods with Sizes beyond Quantum Confinement Regime
No full textUsing Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
Full text linkHi-Spot are highly re-aggregated neural cultures grown on PTFE membrane at the liquidair interface. The Hi-Spot protocol was developed by scientists at Capsant Neurotechnologies using embryonic neural tissue. We characterised Hi-Spots made using existing protocols to confirm they represented a maturing neural network with molecular, cellular and functional signatures. We have additionally modified existing protocols to allow use of postnatal tissue as the source for dissociation and re-aggregation. Hi-Spots made from postnatal day zero (P0) rats self organised into a complex 3D tissue-like structure containing anatomically synaptically-interconnected neurons, astroglia and microglia. This CNS analogue of brain tissue provides for the emergence of a co-ordinated excitatory and inhibitory network, demonstrating a maturing pattern of activity involving single spikes developing into bursting behaviour driven by intrinsic synaptic activity. This activity can be represented as frequency or averaged amplitude (RMS), increases with time in culture and is blocked by glutamate receptor antagonists and stimulated by the inhibitory receptor antagonist bicuculline. The validity of its more in vivo-like organization, not observed in more conventional dissociated cultures, is evidenced by a glutamate toxicity resistance in the Hi-Spot cultures. Further, the thesis describes the optimisations to the Hi-Spot protocol to allow viable high density re-aggregated cultures to be made from individual rather than pooled brain dissociations. Modifications to the protocol included dissociation of the mouse tissue using a protease papain kit and cell plating at an increased cell density. Using this as a platform we have gone on to investigate the neuronal dysfunction occurring in Cysteine String Protein (CSP)?-/- mice. CSP? is a presynaptic protein thought to have co-chaperone like functions, mice lacking CSP? are born alive but show progressive weakness and neuronal degeneration soon after birth (Fernandez-Chacon, Wolfel et al. 2004). Hi-Spots formed from CSP? -/- tissue did not show overt neurodegenerative characteristics compared to +/+ controls and functional analysis demonstrated that at~DIV14 CSP? +/+ and -/- mice displayed equal levels of basal spontaneous network activity. Addition of bicuculline (50?M) to +/+ cultures lead to a significantly increasedfrequency and RMS value. However, in -/- cultures there was no increase induced by bicuculline. This may be due to an inability of CSP? -/- cultures to sustain high frequency synaptic transmission that is associated with bursting activity, or a selective degeneration of a sub-population of inhibitory neurons and a homeostatic network plasticity. The data suggest CSP? may act to protect the ability of neurons for high frequency synaptic transmission and/ or protect inhibitory neurons from degeneration
Association between smoking, Acetaldehyde Dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers.
No full textHIx system thermodynamic model for hydrogen production by the sulfur-iodine cycle
Full text linkThe HIx ternary system (H2O – HI – I2) is the latent source of hydrogen for the Sulfur – Iodine thermo-chemical cycle. After analysis of the literature data and models, a homogeneous approach with the Peng-Robinson equation of state used for both the vapor and liquid phase fugacity calculations is proposed for the first time to describe the phase equilibrium of this system. The MHV2 mixing rule is used, with UNIQUAC activity coefficient model combined with of hydrogen iodide solvation by water. This approach is theoretically consistent for HIx separation processes operating above HI critical temperature. Model estimation is done on selected literature vapor – liquid, liquid – liquid, vapor – liquid – liquid and solid – liquid equilibrium data for the ternary system and the three binaries subsystems. Validation is done on the remaining literature data. Results agree well with the published data, but more experimental effort is needed to improve modeling of the HIx system
VLTI/Hi-5: detection yield predictions for young giant exoplanets
No full textThe Hi-5 instrument, a proposed high-contrast L' band (3.5-4.0 μm) nulling interferometer for the visitor focus of the Very Large Telescope Interferometer (VLTI), will characterize young extra-solar planetary systems and exozodiacal dust around nearby main-sequence stars. Thanks to VLTI's angular resolution (λ=B = 5 mas for the longest UT baseline), it will fill the gap between young giant exoplanets discovered by ongoing single-aperture direct imaging surveys and exoplanet populations discovered by radial velocity surveys. In this paper, we investigate the exoplanet detection yield of Hi-5. First, we present the latest catalog of stars identified as members of young stellar associations within 150 pc of the Sun thanks to the BANYAN algorithm and other searches for young moving group members. Realistic exoplanet populations are then generated around these stars and processed with the SCIFYsim tool, the end-to-end simulator for the Hi-5 instrument. Then, two formation models are used to estimate the giant planet's luminosity. The first is the New Generation Planetary Population Synthesis (NGPPS), also known as the Bern model, and the second is a statistical model based on gravitational instability (hot-start model - AMES-Dusty model). We show that Hi-5 is insensitive to cold-start planets but can detect giant hot-start planets. With ATs, more than 40 planets could be detected assuming 20 nights of observations. With its unique capabilities, Hi-5 is also able to constrain in mass the observed systems. Hi-5 is sensitive to planets with a mass > 2 Mjup around the snow line.Spaceborne Instrumentatio
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