1,281 research outputs found
Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity
No full textAl-Riyami H. Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity. Bielefeld (Germany): Bielefeld University; 2006
Effectiveness of the application of an electronic medication management support system in patients with polypharmacy in general practice: a study protocol of cluster-randomised controlled trial (AdAM)
No full textMüller BS, Klaaßen-Mielke R, Gonzalez-Gonzalez AI, et al. Effectiveness of the application of an electronic medication management support system in patients with polypharmacy in general practice: a study protocol of cluster-randomised controlled trial (AdAM). BMJ open. 2021;11(9): e048191.INTRODUCTION: Clinically complex patients often require multiple medications. Polypharmacy is associated with inappropriate prescriptions, which may lead to negative outcomes. Few effective tools are available to help physicians optimise patient medication. This study assesses whether an electronic medication management support system (eMMa) reduces hospitalisation and mortality and improves prescription quality/safety in patients with polypharmacy.; METHODS AND ANALYSIS: Planned design: pragmatic, parallel cluster-randomised controlled trial; general practices as randomisation unit; patients as analysis unit. As practice recruitment was poor, we included additional data to our primary endpoint analysis for practices and quarters from October 2017 to March 2021. Since randomisation was performed in waves, final study design corresponds to a stepped-wedge design with open cohort and step-length of one quarter.; SCOPE: general practices, Westphalia-Lippe (Germany), caring for BARMER health fund-covered patients.; POPULATION: patients (≥18 years) with polypharmacy (≥5 prescriptions).; SAMPLE SIZE: initially, 32 patients from each of 539 practices were required for each study arm (17200 patients/arm), but only 688 practices were randomised after 2years of recruitment. Design change ensures that 80% power is nonetheless achieved.; INTERVENTION: complex intervention eMMa.; FOLLOW-UP: at least five quarters/cluster (practice). recruitment: practices recruited/randomised at different times; after follow-up, control group practices may access eMMa.; OUTCOMES: primary endpoint is all-cause mortality and hospitalisation; secondary endpoints are number of potentially inappropriate medications, cause-specific hospitalisation preceded by high-risk prescribing and medication underuse.; STATISTICAL ANALYSIS: primary and secondary outcomes are measured quarterly at patient level. A generalised linear mixed-effect model and repeated patient measurements are used to consider patient clusters within practices. Time and intervention group are considered fixed factors; variation between practices and patients is fitted as random effects. Intention-to-treat principle is used to analyse primary and key secondary endpoints.; ETHICS AND DISSEMINATION: Trial approved by Ethics Commission of North-Rhine Medical Association. Results will be disseminated through workshops, peer-reviewed publications, local and international conferences.; TRIAL REGISTRATION: NCT03430336. ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03430336). © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ
Supernatural Power Ritual and Divination in Ancient Israelite Society: A Social-scientific, Poetics, and Comparative Analysis of Deuteronomy 18
No full textThe thesis argued for here is that a social-scientific, poetics, and comparative analysis
reveals that all the religious phenomena listed in Deuteronomy 1 8.10-11 are bound
together in a conceptual unity. The religious practitioners and practices enumerated
properly portray various elements characteristic of ANE religious beliefs in conflict with
an emerging, world-constructing, and ideologically explicit Yahwistic vision of reality.
Furthermore, Deuteronomy presents the Yahwistic prophet, the nābi’ as the preeminent
symbol of Yahwistic reality, which seeks to replace all other notions of reality in the
Israelite community.
This study makes contributions to an interdisciplinary approach to biblical interpretation
by using a combination of social-scientific criticism, poetics literary analysis, and
comparative analysis of ANE religions and ethnographic field studies. Special
significance is given to Meir Sternberg's poetics analysis, Peter Berger's theory of world-construction,
Michael Carrither's theory of intersubjectivity, and Douglas Davies' theory
of clusters of belief This study also makes contributions to the understanding of the
unique role of the Yahwistic prophet as preeminent cultural symbol in Israelite society
The Relation between Treated Maternal Urinary Tract Infection and Adverse Maternal, Prenatal Outcomes in Pregnant Women of Ardabil, Iran
No full textBackground and Objective: Urinary tract infection is one of the most common bacterial infections during pregnancy and has also been implicated as a risk factor for adverse maternal and prenatal outcomes. The aim of our study was to determine the relation between maternal urinary tract infection and adverse maternal, prenatal outcomes in pregnant women of Ardabil, Iran.
Material and Methods: This retrospective-case-control study was conducted on prenatal file records of pregnant women in Ardabil (2011). The pregnant women who had a positive urine culture in their prenatal files (N= 211) were considered as a case group and 232 ones without urinary tract infection as a control. Using a research- made questionnaire, the data related to present pregnancy and prenatal information was collected and analyzed by KrusKal Wallis, Chi- Square and Fisher statistical tests.
Results: Maternal age of under 25 (%61.6 vs. 56.5), body mass index of more than 30 (%18.3 vs. 15.6), primigravida (%55 vs. 48.8), hypertension (%2.4 vs. 1.3), hyperemesis Gravidarum (%14.8 vs. 12.6), frequency and dysuria (%1.9 vs. 0.9), low birth weight (%95.4 vs. 93.2), congenital malformation (%3.5 vs. 1.8), artificial milk feeding (%6.5 vs. 2.7), neonatal death (%0.9 vs. 0.0) are higher in urinary infection group, however the differences are not statistically significant. Other maternal and prenatal adverse outcomes such as diabetes, pre-eclampsia , hemoglobin level, prematurity, abortion and stillbirth have not significant relation with urinary infection.
Conclusion: Because of low level of adverse maternal or prenatal outcomes reported in our study, we conclude that screening and treatment of urinary tract infection in Ardabil health service is appropriate; therefore, no change is needed for present screening or treatment processes
"I must, and I can live with that": a thematic analysis of patients' perspectives on polypharmacy and a digital decision support system for GPs
No full textBrunn R, Muller BS, Flaig B, et al. "I must, and I can live with that": a thematic analysis of patients' perspectives on polypharmacy and a digital decision support system for GPs. BMC family practice. 2021;22(1): 168.BACKGROUND: To investigate patients' perspectives on polypharmacy and the use of a digital decision support system to assist general practitioners (GPs) in performing medication reviews.; METHODS: Qualitative interviews with patients or informal caregivers recruited from participants in a cluster-randomized controlled clinical trial (cRCT). The interviews were transcribed verbatim and analyzed using thematic analysis.; RESULTS: We conducted 13 interviews and identified the following seven themes: the patients successfully integrated medication use in their everyday lives, used medication plans, had both good and bad personal experiences with their drugs, regarded their healthcare providers as the main source of medication-related information, discussed medication changes with their GPs, had trusting relationships with them, and viewed the use of digital decision support tools for medication reviews positively. No unwanted adverse effects were reported.; CONCLUSIONS: Despite drug-related problems, patients appeared to cope well with their medications. They also trusted their GPs, despite acknowledging polypharmacy to be a complex field for them. The use of a digital support system was appreciated and linked to the hope that reasons for selecting specific medication regimens would become more comprehensible. Further research with a more diverse sampling might add more patient perspectives.; TRIAL REGISTRATION: ClinicalTrials.gov, NCT03430336 . Registered on February 6, 2018. © 2021. The Author(s)
Measurement of Bs 0 meson production in pp and PbPb collisions at sNN=5.02 TeV
No full textThe production cross sections of Bs 0 mesons and charge conjugates are measured in proton-proton (pp) and PbPb collisions via the exclusive decay channel Bs 0→J/ψϕ→μ+μ−K+K− at a center-of-mass energy of 5.02 TeV per nucleon pair and within the rapidity range |y|<2.4 using the CMS detector at the LHC. The pp measurement is performed as a function of transverse momentum (pT) of the Bs 0 mesons in the range of 7 to 50 GeV/c and is compared to the predictions of perturbative QCD calculations. The Bs 0 production yield in PbPb collisions is measured in two pT intervals, 7 to 15 and 15 to 50 GeV/c, and compared to the yield in pp collisions in the same kinematic region. The nuclear modification factor (RAA) is found to be 1.5±0.6(stat)±0.5(syst) for 7–15 GeV/c, and 0.87±0.30(stat)±0.17(syst) for 15–50 GeV/c, respectively. Within current uncertainties, the Bs 0 results are consistent with models of strangeness enhancement, and suppression by parton energy loss, as observed for the B+ mesons. © 201
An analysis of hinneh as a discourse marker in Genesis - 2 Kings
No full textPlease find Abstract included as a separate fil
The dark side of mast cells and their role in metastasis
No full textKomarowska Marta Diana, Korakiewicz Gabriela, Pilaszewicz Agata, Hermanowicz Adam, Reszec Joanna, Debek Wojciech, Chyczewski Lech. The dark side of mast cells and their role in metastasis. Journal of Health Sciences. 2014;4(14):273-284. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A273-284
https://pbn.nauka.gov.pl/works/513198
DOI: 10.5281/zenodo.13372
http://dx.doi.org/10.5281/zenodo.13372
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 10.12.2014.
The dark side of mast cells and their role in metastasis
Marta Diana Komarowska1, Gabriela Korakiewicz2, Agata Pilaszewicz2, Adam Hermanowicz1, Joanna Reszec2, Wojciech Debek1, Lech Chyczewski2
Department of Pediatric Surgery, Medical University of Bialystok
Waszyngtona 17
15-274 Bialystok
Department of Medical Pathomorphology, Medical University of Bialystok
Waszyngtona 13
15-269 Bialystok
Poland
Corresponding author
Adam Hermanowicz MD, PhD
Pediatric Surgery Department
Waszyngtona 17
15-274 Bialystok
Tel +48608612288
Email: [email protected]
We confirm that all authors have read and approved the submission of the manuscript, the manuscript has not been published and is not being considered for publication elsewhere, in whole or in part, in any language, except as an abstract. We also declare no financial relationships with any industry (through investments, employment, consultancies, stock ownership, honoraria). The authors declare no conflict of interests.
Word count 4886
Abstract:
Mast cells are one of the best and least understood components of the immune system. They play a crucial role in inflammatory diseases as well as in the promotion of progression of many types of neoplasms. This review covers the most important pathological conditions associated with mast cell activity focusing on inflammatory diseases, e.g. inflammatory bowel disease, chronic pancreatitis, asthma, and mostly on tumor growth and metastases.
Keywords: mast cells, inflammatory diseases, tumor growth, metastases.Komarowska Marta Diana, Korakiewicz Gabriela, Pilaszewicz Agata, Hermanowicz Adam, Reszec Joanna, Debek Wojciech, Chyczewski Lech. The dark side of mast cells and their role in metastasis. Journal of Health Sciences. 2014;4(14):273-284. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A273-284
https://pbn.nauka.gov.pl/works/513198
DOI: 10.5281/zenodo.13372
http://dx.doi.org/10.5281/zenodo.1337
Lepton flavor violation in B decays?
No full textThe LHCb Collaboration’s measurement of RK=B(B+→K+μ+μ−)/B(B+→K+e+e−) lies 2.6σ below the Standard Model prediction. Several groups suggest this deficit to result from new lepton nonuniversal interactions of muons. But nonuniversal leptonic interactions imply lepton flavor violation in B decays at rates much larger than are expected in the Standard Model. A simple model shows that these rates could lie just below current limits. An interesting consequence of our model, that B(Bs→μ+μ−)exp/B(Bs→μ+μ−)SM≅RK≅0.75, is compatible with recent measurements of these rates. We stress the importance of searches for lepton flavor violations, especially for B→Kμe, Kμτ, and Bs→μe, μτ.We are grateful for stimulating conversations with Adam Martin and Edwige Tournefier. We have also benefited from discussions with Wolfgang Altmannshofer, Francesco Dettori, Federico Mescia, Jim Miller, Marco Nardecchia, Chris Quigg, David Straub, Danny van Dyk, and Roman Zwicky. S. L. G.'s research is supported in part by the U.S. Department of Energy under Grant No. DE-SC0010025. K. L. gratefully acknowledges support of this project by the Labex ENIGMASS. He thanks Laboratoire d'Annecy-le-Vieux de Physique Theorique (LAPTh) for its hospitality and the CERN Theory Group for support and hospitality. K. L.'s research is supported in part by the U.S. Department of Energy under Grant No. DE-SC0010106. (DE-SC0010025 - U.S. Department of Energy; DE-SC0010106 - U.S. Department of Energy; Labex ENIGMASS; CERN Theory Group)First author draf
The substance of Psalm 24: an attempt to read scripture after Brevard S. Childs
No full textThis thesis seeks to contribute to the theory and practice of theological interpretation
by explicating the inner coherence of B. S. Childs' "canonical approach" and by exemplifying
that approach in an interpretation of Psalm 24.
Part 1 concerns the theory. In this section I argue that Childs' approach rests upon a
particular understanding of the nature of the Biblical text. In short, it has a twofold function,
that of witnessing to the reality of God and that of shaping the community of faith in light
of that reality. The God to whom it witnesses is himself involved in this witnessing activity
in that he both evokes and infuses the tradition with his Spirit so that he may be known.
The hermeneutical implication is that interpretation must attempt to grasp the reality
"behind" the text while respecting the particular form in which that reality has been
rendered. The result is a multi-level approach to interpretation involving a continuous
dialectic between the witness (verbum) and its content (res). The affirmation of the nature
of Scripture as an ongoing vehicle of revelation also implies the significance of the history
of faithful Christian interpretation.
Part 2 seeks to exemplify this approach by showing how such a multi-level
interpretation of Psalm 24 is both possible and fruitful for our understanding of the reality
to which it witnesses. I achieve this by moving through several stages. After reviewing
contemporary methodology, I first provide a poetic analysis of the Psalm and conclude that
it witnesses to the economy of God in a bid to call Israel to realize its true identity. I then
provide a hypothesis of how the final form of the psalm is a result of a tradition historical
process with its roots in the pre-exilic temple liturgy. This historical perspective not only
clarifies the poetic shape of the psalm, it provides a bridge to discussing the question of the
nature of the reality experienced within Israel's cult. I conclude that there is a parallel
between the structure of this reality and the shape of Ps 24. I then both confirm and
attempt to deepen our understanding of this reality by following canonical pointers
internal to the psalm to three other bodies of text: Samuel, the Psalter, and Isaiah. Key to
this broader context is the agency of the David found in Ps 24's superscription. I conclude
my analysis by suggesting how a better grasp of the divine economy in the light of Christ
may help us better understand the inner unity of Ps 24 itself
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