1,721,125 research outputs found
Supplementary_material__Rv_(TUB-18-0160) – Supplemental material for Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma
No full textSupplemental material, Supplementary_material__Rv_(TUB-18-0160) for Dual loss of USP10 and p14ARF protein expression is associated with poor prognosis in patients with small intestinal adenocarcinoma by Joon Seon Song, Joo Mi Yi, Hanbyoul Cho, Chel Hun Choi, Yoonho Park, Eun Joo Chung, Jaewhan Song, Joon-Yong Chung and Seung-Mo Hong in Tumor Biology</p
Abstract 4718: Filamin A interacting protein 1-like is a marker of prognosis, progression and chemosensitivity in ovarian cancer
No full textAbstract
Purpose: The WNT/β-catenin pathway and the resulting epithelial-to-mesenchymal transition (EMT) play a key role in ovarian cancer progression and chemoresistance. Filamin A interacting protein 1-like (FILIP1L) enhances β-catenin degradation, thereby inhibiting canonical WNT signaling and EMT. FILIP1L is a tumor suppressor whose expression is down-regulated by promoter hyper-methylation in ovarian cancer. FILIP1L down-regulation is inversely correlated with the invasive potential of ovarian cancer cells. However, the clinical relevance of FILIP1L down-regulation in ovarian cancer progression has yet to be addressed.
Experimental design: To study the clinical implications of FILIP1L in regulating the WNT/β-catenin pathway and chemoresistance, the expression of FILIP1L, β-catenin, SNAIL and SLUG was analyzed by immunohistochemistry on tissue microarrays of 369 ovarian samples ranging from normal to metastatic. Their expression was evaluated with clinicopathological characteristics including FIGO stage and chemosensitivity, and correlated with overall and disease-free survival by Kaplan-Meier plots and Cox proportional hazards model.
Results: We demonstrated that FILIP1L expression decreased with tumor progression, resulting in a significant difference between primary and metastatic ovarian cancer samples. In contrast, levels of β-catenin and SLUG increased with tumor progression. Furthermore, tumors that were resistant to platinum/paclitaxel combination therapy showed a significant reduction in FILIP1L expression when compared to sensitive tumors, contrary to SLUG expression, which was significantly higher. The expression of FILIP1L was negatively correlated with the expression of β-catenin and SLUG, whereas β-catenin expression was positively correlated with SLUG expression, suggesting a link between FILIP1L and the WNT/β-catenin pathway in ovarian cancer. Moreover, patients with low FILIP1L expression showed a median overall survival and disease-free survival of 60 and 19 months, respectively, whereas patients with high FILIP1L expression had not yet reached median overall and disease-free survival at their 120 month follow-up. Notably, low FILIP1L expression was independent negative prognostic factor with respect to overall and disease-free survival.
Conclusions: Our study provides the first clinical relevance of FILIP1L in human cancer, and suggests that FILIP1L may be a novel biomarker for good prognosis and lower probability of recurrence in ovarian cancer patients.
Citation Format: Mijung Kwon, Jae-Hoon Kim, Chel Hun Choi, Joon-Yong Chung, Stephen Hewitt, Steven Libutti. Filamin A interacting protein 1-like is a marker of prognosis, progression and chemosensitivity in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4718. doi:10.1158/1538-7445.AM2017-4718</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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