1,980 research outputs found
Observation of hc radiative decay hc › ??' and evidence for hc › ??
No full textKolcu, Onur Buğra (Arel Author) --- Makale 69 yazarlıdır.A search for radiative decays of the P-wave spin singlet charmonium resonance hc is performed based on 4.48 × 108 ? events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels hc › ??' and ?? are observed with a statistical significance of 8.4? and 4.0?, respectively, for the first time. The branching fractions of hc › ??' and hc › ?? are measured to be B(hc › ??' ) = (1.52±0.27±0.29)×10-3 and B(hc › ??) = (4.7±1.5±1.4)×10-4 , respectively, where the first errors are statistical and the second are systematic uncertainties
Financial analysis and evaluation of company HC Betons Ltd
No full textDiplomdarba nosaukums: Uzņēmuma SIA HC Betons finanšu analīze un novērtējums
Diplomdarba mērķis ir uz finanšu analīzes pamata izvērtēt uzņēmuma SIA HC Betons esošo finansiālo situāciju un izstrādāt priekšlikumus finansiālā stāvokļa uzlabošanai.
Teorētiskajā daļā apskatīti finanšu analīzes teorētiskie aspekti. Praktiskajā daļā autore veica uzņēmuma SIA HC Betons finanšu analīzi par 2009., 2010., un 2011.gadu. Analītiskajā daļā autore salīdzina rādītājus ar konkurējošo uzņēmumu SIA Cemex.
Autore secinājusi, ka uzņēmumam ir finansiālas grūtības, bet pēc autores domām, uzņēmums tuvāko gadu laikā nebankrotēs.
Diplomdarba apjoms ir 78 lapaspuses, tas sastāv no 3 daļām, 12 tabulām, 5 attēliem un 12 pielikumiem.
Atslēgvārdi: analīze, likviditāte, bankrots, koeficienti.Diploma thesis: Financial Analysis and Evaluation of Company HC Betons Ltd.
The aim of the diploma paper is to evaluate company’s HC Betons Ltd current financial situation based on financial analysis and make suggestions for improvement of the financial position.
Theoretical aspects of financial analysis are discussed in the theoretical part of the paper. In the practical part author has performed company’s HC Betons Ltd financial analysis of the years 2009, 2010 and 2011. In the analytical part author compares ratios of a competing company Cemex Ltd.
The author concludes that the company is in financial difficulties, but according to the author’s thoughts, the company will not bankrupt in the coming years.
The volume of the diploma paper is 78 pages; it consists of 3 parts, 12 tables, 5 images and 12 appendices.
Keywords: analysis, liquidity, bankruptcy, ratios
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
No full textThe application of a 1H nuclear magnetic resonance (NMR) spectroscopy-based screening method for determining the use of two widely available analgesics (acetaminophen and ibuprofen) in epidemiologic studies has been investigated. We used samples and data from the cross-sectional INTERMAP Study involving participants from Japan (n = 1145), China (n = 839), U.K. (n = 501), and the U.S. (n = 2195). An orthogonal projection to latent structures discriminant analysis (OPLS-DA) algorithm with an incorporated Monte Carlo resampling function was applied to the NMR data set to determine which spectra contained analgesic metabolites. OPLS-DA preprocessing parameters (normalization, bin width, scaling, and input parameters) were assessed systematically to identify an optimal acetaminophen prediction model. Subsets of INTERMAP spectra were examined to verify and validate the presence/absence of acetaminophen/ibuprofen based on known chemical shift and coupling patterns. The optimized and validated acetaminophen model correctly predicted 98.2%, and the ibuprofen model correctly predicted 99.0% of the urine specimens containing these drug metabolites. The acetaminophen and ibuprofen models were subsequently used to predict the presence/absence of these drug metabolites for the remaining INTERMAP specimens. The acetaminophen model identified 415 out of 8436 spectra as containing acetaminophen metabolite signals while the ibuprofen model identified 245 out of 8604 spectra as containing ibuprofen metabolite signals from the global data set after excluding samples used to construct the prediction models. The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling
MMP14 and regulation of hypertrophic chondrocyte to osteoblast lineage
No full textDuring endochondral ossification, the cartilage template is degraded by Matrix
Metalloproteinases (MMPs) and replaced by bone. Hypertrophic Chondrocytes (HCs)
undergo lineage extension and contribute to osteoblasts in trabeculae. However, the role
of MMPs in regulating the lineage transition of HCs to osteoblast is unknown.
MMP14(MT1-MMP), encoded by Mmp14, is a membrane-tethered matrix
metalloproteinase which is highly expressed by cells at the chondro-osseous junction
where lineage extension of HCs occurs. Mice deficient of MMP14 display loss of
trabecular bone and impaired angiogenesis during endochondral ossification. Here we
hypothesize MMP14 regulates the lineage progression of HCs to osteoblasts.
By following the fate of HCs using Col10a1-Cre and Rosa26 reporters, complete
inactivation of MMP14 results in loss of trabecular bone and marked accumulation of
HC-derived cells at the chondro-osseous junction. More HC descendants are found in
MMP14 null mutants. Expression of osteogenic markers such as Collagen type I and Mmp13 are decreased in MMP14 mutants in late postnatal stages. The defect in
progression of HC descendants into primary spongiosa was not caused by HC-specific
loss of MMP14. Simultaneous inactivation of MMP14 and tracing of HC descendants
within a defined time frame does not disrupt their localization in trabecular bone
compared to control. Instead, the accumulation of HC descendants at chondro-osseous
junction in MMP14 null mutants is associated with reduced vascularization in trabecular
bone.
Depletion of MMP14 was known to activate osteoclast activity and compromise
trabecular bone formation. However, conditional ablation of MMP14 in HC descendants
with Col10a1-Cre; Mmp14F/- causes increased trabecular bone and number of HC
descendants. The phenotype could be attributed to decreased apoptosis of HCs at the
chondro-osseous junction. These data suggests HC-derived MMP14 negatively regulate
lineage progression of HCs.
Interestingly, many phenotypes observed in Col10a1-Cre; Mmp14F/- mice is consistent
with activation of parathyroid hormone signalling from literature. Mechanistically, we
found that MMP14 interacts and cleaves parathyroid hormone 1 receptor (PTH1R) which
is expressed in both osteoblasts and chondrocytes. Haploid-insufficiency of pth1r
partially rescues postnatal trabecular bone formation in Mmp14-/- mice. Our work
unravels multiple roles of MMP14 in lineage progression of Hypertrophic Chondrocytes.published_or_final_versionBiomedical SciencesDoctoralDoctor of Philosoph
Specific and fitness testing of goalies HC Motor Czech Budejovice\\
No full textThe aim of this bachelor thesis is to test specific and fitness abilities of goalkeepers of HC Motor Czech Budejovice. In the theoretical part of this thesis, based on content analysis of literature research, the author presents motoric abilities, development patterns and overview of most frequently used tests. In the practical part of thesis, the author deals with creating and verifying tested battery. It was designed using the knowledge gained from books reference and self- experience of a player and a coach as well. To obtain the results of performance of particular motoric abilities the author used testing method. The outcomes were subsequently compared with the evaluation of given motoric abilities on ice. The author acquired the evaluation from goalkeeper's coaches of HC Motor Czech Budejovice. Final results are described and thereafter tabularly presented
VIBRATIONAL RELAXATION IN THE BINARY GASEOUS MIXTURES AND
No full textAuthor Institution: Laboratoire de Spectronomie Moleculaire, Universit\'e de Paris VI, 4, Place Jussieu - Tour 13Vibrational relaxation rates for gaseous mixtures , with or , in which vibrational energy transfer can occur from the level of M to the v = 1 level of , has been measured as a function of the temperature using the laser-induced vibrational fluorescence technique. The relaxation processes which must be considered are: - the V-V transfer process: \begin{eqnarray*} &&M(00^{\circ }1)+ HC (v=0)\begin{array}{c}^{k}M-HC\ell\\ \rightleftharpoons\\ ^{k}HC\ell-M\end{array}M(00^{\circ}0)+ HC\ell(v=1)+ \Delta E=he\Delta\nu\\ &&with\ \Delta\nu=-537\, cm^{-1} for\ CO_{2}, -663\, cm ^{-1}\ for\ N_{2}O \end{eqnarray*} - the V-TR de-excitation processes: \begin{eqnarray*} M(00^{\circ}1)+ HC\ell(or M)\stackrel{k^{HC\ell}_{M}}{(o\vec{r}\; k_{M})}M(mn^{\ell}0)+HC\ell (or \; M)\\ HC\ell(v=1)+ M(or\; HC\ell)\stackrel{k^{M}_{HC\ell}}{(o\vec{r}\; k_{HC\ell})}HC\ell(v=0)+M(or \; HC\ell) \end{eqnarray*} For most of the systems in which near-resonant V-V transfers occur, the V-TR de-excitation rates are negligible compared to the V-V transfer rates. But this is not the case for the M-HC systems considered in this work. The de-excitation rates and are of the same order of magnitude as the V-V transfer rates and respectively. In order to determine separately all these rates, relaxation measurements have been performed by exciting either H to the level or to the v = 1 level, and measuring the relaxation rates versus the molar fraction of the gas excited by laser. The results are discussed and compared with the values of the rates calculated by using a Morse potential as the intermolecular potential, and according to a semi-classical method in which a vibration-rotation exchange is assumed
VIBRATIONAL COUPLINGS AND ENERGY FLOW IN COMPLEXES OF HC=CH, HC=CD, HC=CC=C, AND N=CH WITH
No full textAuthor Institution: Molecular Physics Division, National Institute of Standards and Technology; Molecular Physics Divisoin, National Institute of Standards and TechnologyInfrared spectra of the C-H stretching vibrations of the symmetric-top complexes, , have been recorded using a color-center-laser electric-resonance optothermal spectrometer. Efforts to observe the N-H stretches were unsuccessful. The hydrogen-bonded C-H stretching modes of HC=CH--NH3 are strongly coupled to the hydrogen bond as evidenced by their large monomer red-shifts of 75 and and broad predissociation linewidths of 2000 ad 650-800 MHz, respectively. The complexation-induced asymmetry in is not sufficient to allow us to observe the local mode associated with the outer C-H stretch. However, isotopic substitution in shows that this mode is red shifted by less than from the monomer vibration. The narrow predissociation linewidths of this mode (7-12 MHz) are consistent with this small red shift. The weaker coupling of the C-H stretches in HC=CC=CH is completely quenched upon complexation with . The outer C-H stretch is observed in the diacetylene (HC=CC=CH) complex, blue shifted by approximately from the infrared-active monomer C-H stretch at ; the bound CH stretch is red shifted about the same amount as in . These observations imply that the weak coupling of the local modes in diacetylene is significantly quenched upon complexation with . The predissociation linewidths are similar to those in , even though the outer C-H stretch is now five bonds away from the hydrogen bond. Surprisingly, these results suggest that the length of the triple-bond backbone in acetylene chains does not significantly impede the rate of vibrational energy flow. Future efforts will be made to extend these studies to the triacelyne complex,
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Development of raised access floor panel by optimisation techniques
No full textRaised access floor panels currently have a chipboard core and are encapsulated within thin layer of galvanised steel. Two key problems with these raised access floor panels are that they are heavy because of the chipboard and expensive, as the cost of steel has increased significantly over the past few years. The consequence of the raised access floor panel’s mass is that they are difficult to handle, they are expensive to transport and they add considerably to the load on a structures foundation. Glass fibre filled epoxy of floor panels were designed and optimised to achieve lighter weights without compromising their strength using Altair Hypermesh software. A material weight reduction of the glass fibre filled epoxy floor panel was achieved by optimised design of the panes using an evolutionary structural optimisation (ESO) method and the introduction of panel ribs. The lighter weight of new raised floors panel would have a significant impact on the loadings of buildings foundation and allow architects to reduce the carbon footprint of a building resulting in reduced construction costs. In addition, a reduction in the weight of the new raised access floor panels would reduce the transportation costs of the panels
Measurements of hc(P11) in ψ ′ Decays
No full textWe present measurements of the charmonium state hc(P11) made with 106×106 ψ ′ events collected by BESIII at BEPCII. Clear signals are observed for ψ ′→π0hc with and without the subsequent radiative decay hc→γηc. First measurements of the absolute branching ratios B(ψ ′→π0hc)=(8. 4±1.3±1.0)×10 -4 and B(hc→γηc)=(54. 3±6.7±5.2)% are presented. A statistics-limited determination of the previously unmeasured hc width leads to an upper limit Γ(hc)<1. 44MeV (90% confidence). Measurements of M(hc)=3525.40±0.13±0. 18MeV/c2 and B(ψ ′→π0hc) ×B(hc→γηc)=(4.58±0.40±0.50)×10 -4 are consistent with previous results. © 2010 The American Physical Society.published_or_final_versio
Functional analysis of the Wnt-Irx regulatory axis in the chondrocyte-osteoblast lineage and metabolic homeostasis
No full textIt has been established that chondrocytes and osteoblasts comprise a lineage continuum by which hypertrophic chondrocytes (HCs) become osteoblasts and osteocytes, contributing to bone formation. However, the gene regulatory network that controls the chondrocyte to osteoblast transformation and cell fate decision is poorly understood. The possibility that a small proportion of HCs can also become adipocytes has been suggested, but the underlying mechanism has not been established. Here, I show that β‑catenin regulates gene expression of Irx3/5 in developing trabecular bone to determine the cell fate of HC descendants. The loss of β‑catenin and the downstream target IRX3/5 in the HC lineage results in significantly elevated numbers of adipocytes, contributing to an increased amount of bone marrow adipose tissue (BMAT), which becomes apparent in early neonates (P10). I found that the reduction in bone and increase in BMAT are mainly caused by an increase in the number of HC-derived bone marrow adipocytes and a decrease in the number of HC-derived osteoblasts, implicating Wnt signalling and IRX3/5 as key regulators of osteogenesis versus adipogenesis in trabecular bone formation. In Ctnnb1 CKO mice (conditional knockout of β‑catenin by Col10a1Cre), bone marrow adiposity is elevated with no genetic manipulation in peripheral adipose tissue, representing a novel mouse model for studying the function of bone marrow adipose tissue in global metabolism. Ctnnb1 CKO mice demonstrate significant metabolic changes, including a lower body fat composition and improved glucose tolerance and insulin sensitivity under a normal chow diet, which are likely consequences of an increased metabolic rate and increased thermogenesis/lipolysis activity. Furthermore, Ctnnb1 CKO mice are resistant to high-fat diet-induced obesity. The metabolic improvements in Ctnnb1 CKO mice suggest that bone marrow adipose tissue may be a novel endocrine organ involved in maintaining metabolic health and preventing the metabolic deficiency induced by unhealthy food intake. Interestingly, tdTomato expression driven by Col10a1Cre suggests that Cre recombinase may be activated in not only hypertrophic chondrocytes in the bone system but also various types of neurons in the olfactory system. The metabolic phenotypes of Ctnnb1 CKO mice have some degrees of similarity with mice with smell sensing deficiency under a high-fat diet. These findings raise the possibility that the olfactory system may also be related to the metabolic improvements in Ctnnb1 CKO mice, although the underlying mechanism requires further validation.
In conclusion, my findings demonstrate that a Wnt-Irx regulatory axis controls HC lineage fate and whole-body metabolic homeostasis and extend the understanding of the relationship among trabecular bone mass, marrow adipose tissue and metabolic control with important implications for metabolic disorders, such as diabetes and obesity, and congenital and aged-related skeletal disorders, such as chondrodysplasia and osteoporosis. Bone marrow adipose tissue can be an emerging key regulator of global metabolism. In the future, the molecular basis underlying the control of metabolic homeostasis by marrow adipose tissue should be further explored, and the potential interaction between marrow adipose tissue and the nervous system requires further investigation.published_or_final_versionBiomedical SciencesDoctoralDoctor of Philosoph
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