1,721,004 research outputs found
Applications des techniques d'electromyographie et de manometrie de l'intestin grele a l'etude de la pharmacologie de la motricite intestinale chez l'homme
No full textSIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Les mucosectomies de polypes colorectaux de plus de 20 mm autorisent-elles une prise en charge ambulatoire ?
No full textPARIS7-Xavier Bichat (751182101) / SudocSudocFranceF
Mécanismes d'action des inhibiteurs de COX2 impliqués dans la régression des adènomes coliques
No full textLes inhibiteurs de la cyclooxygénase 2 réduisent le risque de cancer colorectal par des mécanismes imparfaitement compris. Nous avons analysé par microarrays le transcriptome d'adénomes de souris Apc 14/+ afin d'identifier les gènes qui réagissent à ces médicaments. Méthodes : Des souris Apc 14/+ ont reçu une injection quotidienne de parecoxib. Leur intestin a été analysé par microarrays, immunohistochimie, hybridation in situ et RT-PCR quantitative en temps réel. Les résultats ont été confirmés sur des souris Apclox/lox vil-CreERT2, la lignée colique CT26 et des tumeurs coliques humaines. Résultats : L'expression de l'ostéopontine, marqueur de la progression tumorale colique, était inhibée dans les polypes de souris Apc traitées. Ces souris avaient une survie prolongée et une charge tumorale réduite. L'inhibition de l'ostéopontine survenait rapidement et deux composants de son réseau de régulation le récepteur nucléaire orphelin NR4A2 et la voie Wnt/b-caténine était réprimés séquentiellement. NR4A2 activait le promoteur de l'ostéopontine dans la lignée CT26. Cet effet était bloqué par mutation du site de fixation de NR4A2, transfection d'un mutant dominant négatif de NR4A2, et cotransfection d'ARN anti-sens anti-NR4A2. L'expression de NR4A2 était augmentée tout au long de la progression tumorale, mais contrairement à l'ostéopontine, n'était pas corrélée au stade tumoral. L'expression de NR4A2 était diminuée dans les adénomes de patients recevant du rofecoxib. L'inhibition de l'ostéopontine, probablement par l'intermédiaire de la répression de NR4A2 et de la voie Wnt/b-caténine, est un composant important de l'activité antitumorale des inhibiteurs de cyclooxygénase 2.Background & Aims: Cyclooxygenase-2 inhibitors reduce colon cancer risk by mechanisms that are not fully understood. We performed microarray analysis of adenomas from Apc 14/+ mice to identify genes that respond to these drugs. Methods: Apc 14/+ mice were given a single daily injection of parecoxib for up to 9 weeks; intestinal tracts of these and control mice were analyzed by microarray analysis, immunohistochemistry, in situ hybridization, and quantitative real-time PCR. Findings were further assessed using Apclox/lox vil-CreERT2 mice, the CT26 cancer cell line, and human colon tumour samples. Results: Microarray analysis revealed that osteopontin, a marker of colon cancer progression, was downregulated in polyps from Apc 14/+ mice given parecoxib, compared with controls. Apc 14/+ mice given parecoxib had longer survival times and reduced polyp burdens. Osteopontin was quickly downregulated by parecoxib in intestinal polyps from Apc 14/+ mice and 2 components of the osteopontin regulatory network the orphan nuclear receptor NR4A2 and Wnt/b-catenin signalling were sequentially repressed. NR4A2 activated the osteopontin promoter in CT26 cells; this effect was blocked by mutation of the NR4A2 binding response element, cotransfection of a dominant-negative form of NR4A2, and small inhibitory RNA against NR4A2. NR4A2 levels were increased throughout tumor progression in Apc 14/+ mice, but unlike osteopontin, did not correlate with tumor stage. NR4A2 levels were reduced in adenomas from patients treated with rofecoxib. Conclusions: Downregulation of osteopontin, probably through blockade of NR4A2 and Wnt signalling, is an important component of the antitumour activity of COX2 inhibitors. These factors might be developed as therapeutic targets for intestinal cancers.PARIS5-BU Méd.Cochin (751142101) / SudocSudocFranceF
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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