1,721,486 research outputs found

    ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors.

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    Christopher Abbosh and Charles Swanton discuss circulating tumor DNA as a potential biomarker for neoadjuvant treatment response in solid tumors

    ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors.

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    Christopher Abbosh and Charles Swanton discuss circulating tumor DNA as a potential biomarker for neoadjuvant treatment response in solid tumors

    Analysis of intratumor heterogeneity unravels lung cancer evolution

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    © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Elza C de Bruin, Nicholas McGranahan, and Charles Swanton. Lung cancer is a disease with dismal outcome. We recently reported a detailed intratumor heterogeneity analysis in 7 non-small cell lung cancer samples, revealing spatially separated driver events as well as the temporal dynamics of mutational processes and demonstrating an important role for APOBEC-mediated heterogeneity later in disease evolution

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    sj-xlsx-6-tmj-10.1177_03008916221133136 – Supplemental material for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

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    sj-xlsx-6-tmj-10.1177_03008916221133136 for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options by Spencer H Shao, Brian Allen, Jessica Clement, Gina Chung, Jingjing Gao, Earl Hubbell, Minetta C Liu, Charles Swanton, WH Wilson Tang, Habte Yimer and Mohan Tummala in Tumori Journal</p

    sj-xlsx-5-tmj-10.1177_03008916221133136 – Supplemental material for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

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    sj-xlsx-5-tmj-10.1177_03008916221133136 for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options by Spencer H Shao, Brian Allen, Jessica Clement, Gina Chung, Jingjing Gao, Earl Hubbell, Minetta C Liu, Charles Swanton, WH Wilson Tang, Habte Yimer and Mohan Tummala in Tumori Journal</p

    sj-pdf-4-tmj-10.1177_03008916221133136 – Supplemental material for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

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    sj-pdf-4-tmj-10.1177_03008916221133136 for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options by Spencer H Shao, Brian Allen, Jessica Clement, Gina Chung, Jingjing Gao, Earl Hubbell, Minetta C Liu, Charles Swanton, WH Wilson Tang, Habte Yimer and Mohan Tummala in Tumori Journal</p

    sj-pdf-3-tmj-10.1177_03008916221133136 – Supplemental material for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

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    sj-pdf-3-tmj-10.1177_03008916221133136 for Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options by Spencer H Shao, Brian Allen, Jessica Clement, Gina Chung, Jingjing Gao, Earl Hubbell, Minetta C Liu, Charles Swanton, WH Wilson Tang, Habte Yimer and Mohan Tummala in Tumori Journal</p
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