1,720,980 research outputs found
Heterogeneity of hepatocellular carcinoma contributes to cancer progression
No full textHepatocellular carcinoma (HCC) is a highly heterogeneous disease displaying differences in angiogenesis, extracellular matrix proteins, the immune microenvironment and tumor cell populations. Additionally, genetic variations and epigenetic changes of HCC cells could lead to aberrant signaling pathways, induce cancer stem cells and enhance tumor progression. Thus, the heterogeneity in HCC contributes to disease progression and a better understanding of its heterogeneity will greatly aid in the development of strategies for the HCC treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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The role of Erk MAPK pathway in CD4 T cell proliferation and differentiation
Get PDFThe Erk (Extracellular signal-regulated protein kinase) signaling pathway is thought to be critical for T cell survival, proliferation and differentiation. However, the role of Erk in Th1 and Th2 differentiation is controversial. Most of the previously published studies used a MEK inhibitor to examine the function of Erk in CD4 T helper cell and induced regulatory T cell differentiation; yet the role of Erk2 and its distinction from Erk1 in CD4 T effectors and regulatory cells remains unclear. In this study, we used germline Erk1 knockout mice and tamoxifen-regulated conditional Erk2 knockout mice to identify the role of these two major Erk isoforms within mature CD4 T cells. In vitro studies have revealed that Erk1 is dispensable for most aspects of CD4 T cell activation, while Erk2 performs several non-redundant functions. In the scope of this research project, we observed that Erk2 supported early CD4 T cell proliferation, as well as the differentiation of Th1, but not Th2 or Th17 cells. In addition, virus-specific Th1 responses in the absence of Erk2 were greatly impaired, Furthermore, the reduction in Erk2 signaling enhanced induced regulatory T cell (iTreg) function in vitro and in vivo. Both Erk1-/- and Erk2-/- nature regulatory T cells can suppress CD4 T cell proliferation similar to wild type. In addition, when compared to wild type T cells, we observed down-regulated DNA methyltransferase (DNMT), and increased phospho-Smad2/3 in Erk2-/- CD4 T cells cultured under iTreg conditions. We hypothesized that this decrease in DNMT and increase in TGFbeta signing is induced by an increase in Foxp3 expression. In summary, this study demonstrates that Erk2 plays an important role in CD4 T cell proliferation and differentiation in vitro and in viv
Fertility patterns among the minority populations of China: A multilevel analysis
Get PDFSociological and demographic analyses of minority fertility in the United States have suggested that the processes of socioeconomic, cultural, marital, and structural assimilation will lead to convergence in fertility. So far, little research has used the assimilation approach to study the fertility of the minority populations of China, and also, no research has taken both individual-level and group-level characteristics as predictors.
Using micro-data from the One Percent 1990 Census of China, this dissertation performs multilevel analyses, hierarchical generalized linear modeling, to examine the effects of assimilation and the one-child policy at both the individual level and the group level on minority women's fertility.
Several patterns are found in the multilevel analyses. First, the contextual characteristics of minority groups have strong correlations with fertility across thirty major minority groups in China. It suggests that community power and subculture have strong influences on women's decisions regarding their number of children. Second, the effect of the one-child policy is positive and highly significant on minority women's fertility. However, the strong policy effect does not cover the effect of assimilation. After controlling for policy, the impact of all the assimilation predictors, at both the individual and group level, still remains statistically significant. At the individual level, minority women's educational level, occupational status, status of intermarriage, and migration status have significant and positive impacts on their fertility. At the group level, the levels of minority groups' residential segregation, educational segregation, illiteracy, intermarriage rate, and their Moslem group culture have significant and negative impacts on individual women's fertility. Third, several cross-level interactions in the rural models are not consistent with the complete models, which suggests that some indirect effects of assimilation on minority fertility may come from the urban minorities. Finally, in addition to the direct impacts of socioeconomic, marital, and cultural assimilation on minority fertility, several cross-level interactions are significant and indirectly affect women's fertility. Findings reported in this dissertation indicate a successful integration of individual and contextual variables in analyses of minority fertility. The results contribute to the understanding of the assimilation impacts on minority fertility in China
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