1,121 research outputs found
Effects of switching from olanzapine to aripiprazole on the metabolic profiles of patients with schizophrenia and metabolic syndrome: a double-blind, randomized, open-label study [Corrigendum]
No full textWani RA, Dar MA, Chandel RK, et al Title of paper should have been “Effects of switching from olanzapine to aripiprazole on the metabolic profiles of patients with schizophrenia and metabolic syndrome: a randomized, open-label study”. Read the original paper 
Generalized TASE-RK methods for stiff problems
No full textA family of Time-Accurate and Stable Explicit (TASE) methods for the numerical integration of Initial Value Problems in stiff Ordinary Differential Equations (ODEs) y'(t) = f (t, y) was recently introduced in [1]. The main idea was to make local extrapolation of a stabilized Euler method. More recently, in [3] a similar approach by considering the stabilization of arbitrary explicit Runge-Kutta methods (TASE-RK) was analyzed. In this case the explicit Runge-Kutta method integrates a transformed ODE obtained by multiplying the vector field f (t, y) by a certain operator which approximates the identity mapping up to a given order p. The main inconvenience of both approaches is that to reach order p the solution of p2 linear systems plus the evaluation of p derivatives are required per integration step.In order to substantially reduce the computational costs of the former approaches in the linear system solution, but maintaining the good accuracy and stability properties, a new family of TASE-RK methods which allow to introduce a few more free parameters are considered. The formulation of the methods was conceived to be implemented not only in sequential mode but it admits parallelism in a straightforward way. Furthermore, since these methods are linearly implicit, connections to the class of W-methods [19] are properly established. The order conditions for the new class of methods are widely studied by using the rooted tree theory. For p = 3, 4, new methods with p sequential stages and order p are derived and compared on semidiscrete 1D and 2D Partial Differential Equations (PDEs) to those in [1,3] and other standard Rosenbrock and W-methods in the literature.(c) 2023 The Author(s). Published by Elsevier B.V. on behalf of IMACS. This is an open access article under the CC BY-NC-ND license (http:// creativecommons .org /licenses /by-nc -nd /4 .0/)
The morphological effects of sediment diversions the Lower Mississippi River
No full textThe wetlands in the Mississippi delta (USA) are drastically subsiding and eroding. Many projects and researches are ongoing to determine how this “drowning effect” of the delta can be stopped. One of the solutions that could be feasible is implementing sediment diversions in the levees of the Lower Mississippi River in order to divert sediment into the delta. This thesis addresses the morphological effects of river diversions on the Lower Mississippi River. The main objective is to analyze and optimize trade-offs between delta building and river navigability. For this purpose a 2DH numerical model with Delf3D has been created; the model simulates the hydro- and morphodynamic behavior. The river reach which has been studied is the final 110 km of the river from Point a la Hache at River Kilometer 78 (RK 78) down to the mouth of the river (RK -30), below Head of Passes. The hydrodynamic model has been calibrated and verified with flow and stage data from daily observations on the river. With the available sediment data a calibration has been carried out of the morphological behavior in the river. The model has been used to simulate several scenarios to get insight in the problems in the delta. From analysis of the model results the river bed in the study area can be divided into three categories. Upstream of RK 4 the bed is subject to erosion, around RK 4 the bed is practically in equilibrium and downstream of RK 4 the bed is subject to sedimentation. The reach downstream of RK 4 is the dredging reach; after analyzing the long-term simulation of 20 years it is not expected that the dredging quantities will decrease in the future. Closing off West Bay diversion has a positive effect on the dredging quantities. The best diversion site for this study area is found in the inner bend of the river upstream of Empire (RK 47) at RK 53. This site is most efficient and diverts the largest quantities of sand through the diversion.Hydraulic EngineeringCivil Engineering and Geoscience
The Dunston Manuscript
No full textVariously titled 80 Slides and a Memory, Fit for a King and others this is the definitive performed version as an invited reading in 2001 to the Urban Design Group. It describes in blank verse the early stages of the Gateshead Garden Festival illustrated with slide
Effects of switching from olanzapine to aripiprazole on the metabolic profiles of patients with schizophrenia and metabolic syndrome: a double-blind, randomized, open-label study
No full textRayees Ahmad Wani, Mansoor Ahmad Dar, Rajesh Kumar Chandel, Yasir Hassan Rather, Inaamul Haq, Arshad Hussain, Altaf Ahmad MallaDepartment of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, IndiaBackground: Patients with schizophrenia suffer high rates of metabolic derangements on some antipsychotic medications that predispose them to cardiovascular diseases. Keeping this fact in mind, we planned this open-label study to see the effect on various metabolic parameters after switching stable schizophrenia subjects, who had developed metabolic syndrome on olanzapine, to aripiprazole.Methods: Sixty-two patients with schizophrenia who were stable on olanzapine and were fulfilling modified National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III) criteria for the presence of metabolic syndrome were enrolled on the study. Patients were randomly assigned either to switch to aripiprazole or to stay on olanzapine, on a 1:1 basis. Cross-tapering over a period of 1 month was done while switching patients to aripiprazole. Laboratory assessment for metabolic parameters was done at baseline, 8 weeks, and 24 weeks after enrollment; efficacy assessment was done using the Positive and Negative Syndrome Scale (PANSS) at baseline and 24 weeks, the Clinical Global Impressions severity subscale (CGI-S) at baseline, and the Clinical Global Impressions improvement subscale (CGI-I) at 24 weeks.Results: All parameters of metabolic syndrome (waist circumference, blood pressure, triglyceride level, fasting blood glucose, and high-density lipoprotein cholesterol) kept deteriorating in the stay group, compared with a continuous improvement in the switch group over time. At the end of the study, 26 patients (100%) from the stay group and 15 patients (42.8%) from switch group met the modified NCEP ATP-III criteria for presence of metabolic syndrome (P<0.001). There were no statistically significant differences between groups in psychopathology changes as measured by the PANSS total score and CGI-I scores.Conclusion: Clinically stable patients with schizophrenia who are taking olanzapine and who have evidence of metabolic syndrome can be successfully switched to aripiprazole, with improvement in various parameters of metabolic syndrome and without any significant change in efficacy measures.Keywords: metabolic syndrome, olanzapine, aripiprazole, schizophrenia, switchin
Cost of Conservation of Agrobiodiversity
No full textThe cost of conservation of germplasm stored in gene banks i.e., ex-situ collections has been studied in other parts of the world to estimate direct and indirect contributions by various actors involved in conservation. This is the first study of its kind in India done in collaboration with National Bureau of Plant Genetic Resources, New Delhi. This was part of a sponsored research by Centre for Development Research, Germany. The limitations of this study are also listed so that future research in this regard can be pursued better. One of the costs not included is the cost of sharing data with local communities for enabling them to access germplasm in times of need. This is an important component of conservation and would require translation of gene bank and associated database in local language, making them available through public kiosks. This cost has not been included in any study on the subject so far. Separately, studies are underway to look at the conservation of germplasm under in-situ conditions.
Associating Gender with Neighbourhood Deprivation in Lagos State, Nigeria
No full textAJOL has removed this paper from the website after it was found to be published in another academic publication. AJOL has requestd that both journal editorial boards investigate this matter further with the author
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Transcriptions of Albanian Violin Music for Viola: History, Musical Style and Teaching Tools for the Intermediate to Advanced Player
No full textABSTRACTTranscriptions of Albanian Violin Music for Viola: History, Musical Style and Teaching Tools for the Intermediate to Advanced Player byBesnik YzeiriThe aim of the present study was fourfold: to add valuable new pieces to the viola repertoire; to do so specifically highlighting Albanian classical music; to develop a methodology for making transcriptions for that instrument; and to demonstrate the usefulness of such works specifically to guide intermediate and advanced viola performance students toward higher technical levels. The author accomplished these goals by carefully choosing appropriate pieces, exploring and comparing the transcribing methodologies of William Primrose, Watson Forbes, and Lionel Tertis, and synthesizing a framework for accomplishing the best transcription method for the task. The author then applied this framework specifically to Albanian composer Pjetër Gaci’s Concertino and Concerto for Violin and Piano, transcribing them for viola and piano, and finally using these transcriptions as case studies as teaching tools for intermediate to advanced viola students
Rankine models for time-dependent gravity spreading of terrestrial source flows over subplanar slopes
No full textGeological mass flows extruding from a point source include mud, lava, and salt issued from subsurface reservoirs and ice from surface feeders. The delivery of the material may occur via a salt stock, a volcanic pipe (for magma and mud flows), or a valley glacier (for ice). All these source flows are commonly skewed by a superposed far-field velocity vector imposed by the topographic slope and thus develop plumes having a wide range of shapes. The morphological evolution of the perimeter of the plumes (in plan view) can be simulated by varying the key parameters in a simple analytical flow description on the basis of Rankine equations. Our model systematically varies the strength of the point source relative to the downslope far-field velocity of its expelled mass. The flow lines are critically controlled by the relative speed of the two rates, which can be concisely expressed by the dimensionless Rankine number (Rk, introduced in this study). For steady flows, plume widths can be expressed as a function of Rk. The viscosity of the rock, mud, or lava mass involved in the gravity flow affects Rk and thus the appearance of the plumes. For unsteady source strength, Rk becomes time dependent and the plume width varies over time. The model flow shapes suggest that the plume shapes of natural gravity flows of terrestrial surface materials (mud, lava, salt, and ice) commonly express fast initial flux of the source, followed by an exponential decline of the source strength. Flows having initially higher Rk but otherwise equal life cycles create broader plumes. Peaks in the source flux due to magmatic pulsing during the eruption cycle can explain the formation of pillow lavas. Rather than instantaneously reaching full strength before declining, some natural source flows start by swelling slowly, leading to the creation of unique plume shapes like a flying saucerGeoscience & EngineeringCivil Engineering and Geoscience
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