926 research outputs found
Bio-inspired Conversion of Solar Energy to Chemical Energy through Photochemical Regeneration of NADH by Silicon Nanowires Chemical
No full textCUHK electronic theses & dissertations collection
No full textLyu, Kai.Thesis Ph.D. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 498-539).Abstracts also in Chinese.Title from PDF title page (viewed on 06, December, 2016)
CUHK electronic theses & dissertations collection
No full textLyu, Chen.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 148-159).Abstracts also in Chinese.Title from PDF title page (viewed on 04, October, 2016)
Methods and applications of using DNA-cleaving DNAzymes to cleave double-stranded DNA
No full textSubmission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01The student, Mingkuan Lyu, accepted the attached license on 2022-11-16 at 09:09.The student, Mingkuan Lyu, submitted this Dissertation for approval on 2022-11-16 at 09:42.This Dissertation was approved for publication on 2022-11-29 at 17:16.DSpace SAF Submission Ingestion Package generated from Vireo submission #18585 on 2023-12-04 at 17:29:48DNAzymes are DNA molecules that can catalyze specific reactions. Like protein-based enzymes, DNAzymes have high efficiency and specificity, yet they also own additional advantages such as more feasible customizability and lower cost. Particularly, DNAzymes that catalyze the cleavage of another DNA molecule, called DNA-cleaving DNAzymes, may specifically recognize and cleave user-defined DNA sequences with high efficiency. However, there are only limited applications of DNA-cleaving DNAzymes, because they could only recognize and cleave single-stranded DNA (ssDNA), whereas most DNA targets of interest (such as eukaryotic genomic DNA) are double-stranded DNA (dsDNA). To overcome this limitation, methods that can expand the substrate scope of DNA-cleaving DNAzymes from ssDNA to dsDNA are investigated. Here, a system called peptide nucleic acid (PNA)-assisted dsDNA nicking by DNAzymes (PANDA) is proven to be the first example of using DNA-cleaving DNAzymes to cleave dsDNA. PANDA may recognize almost any user-defined target sequences and cleave the target in a sequence-specific manner. The application of PANDA to mimic restriction enzymes is proven by using PANDA systems in molecular cloning. The potential and barriers of using PANDA systems in genome editing are investigated and discussed. Then, another system called ssDNA-assisted dsDNA nicking by DNAzymes (DANDA) is described, which proves that PANDA is not the only method to expand the substrate scope. The unique feature of DANDA to selectively cleave negatively supercoiled dsDNA rather than relaxed dsDNA has inspired a novel DNA detection method that has specificity on the target superhelicity. These results have proved that using DNA-cleaving DNAzymes to cleave dsDNA is feasible and has huge potential for further applications
CUHK electronic theses & dissertations collection
No full textLyu, Peng.Thesis M.Phil. Chinese University of Hong Kong 2015.Includes bibliographical references (leaves 42-44).Abstracts also in Chinese.Title from PDF title page (viewed on 14, November, 2016)
The analysis of reservoir operation rules in the southwestern United States using a hidden Markov-decision tree model
No full textRealistic reservoir operation is an important component in basin hydrological models. However, the operation rules can be complex under various situations and are not well understood yet. The objective of the study is to find out patterns of actual reservoir operation rules in a specific region under different conditions. The results are helpful to understand realistic reservoir operation behaviors. Moreover, the work will contribute to building a reservoir component for hydrological models and provide references for improving reservoir operation decisions in the future.
A hidden Markov-decision tree (HM-DT) model is applied in this study. Hidden Markov Model is used to describe the transition between operation states while each state corresponds to a decision tree model to determine daily reservoir releases. This study collected the historical records of 66 reservoirs in the southwestern United States and 8 reservoirs in the northern United States and identified their regional representative operation modules.
A comparison between the representative operation modules was conducted to show the spatial variability of reservoir operations. Further, by analyzing the historical operation patterns of several reservoirs, the transitions between operation rules in different time periods were explored, including periodicity and special responses to floods. The operation rules adopted by reservoirs with different operation functions are also analyzed and compared. A robustness analysis was performed to confirm the robustness of the HM-DT model outputs. Finally, several attempts have been made to link the HM-DT model with Soil and Water Assessment Tool (SWAT) and future work is proposed.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01The student, Lingqi Lyu, accepted the attached license on 2021-04-24 at 09:10.The student, Lingqi Lyu, submitted this Thesis for approval on 2021-04-24 at 09:21.This Thesis was approved for publication on 2021-04-27 at 16:26.DSpace SAF Submission Ingestion Package generated from Vireo submission #16543 on 2021-09-16 at 17:05:11Made available in DSpace on 2021-09-17T02:34:47Z (GMT). No. of bitstreams: 2
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Nidirana occidentalis Lyu & Chen & Yang & Zeng & Wang & Zhao & Wan & Pang & Wang 2020, sp. nov.
No full textNidirana occidentalis sp. nov. Lyu, Yang, and Wang Chresonymy Rana pleuraden— Yang and Rao 2008 (Longling, Baoshan, and Tengchong) Pelophylax pleuraden— Fei et al. 2009 (Longling, Baoshan, and Tengchong) Dianrana pleuraden— Fei et al. 2012 (Western Yunnan) Babina pleuraden— Chan and Bi 2016 (Tengchong) Nidirana pleuraden— Lyu et al. 2017 (Mt. Gaoligong) Holotype. SYS a003776, adult male, collected by Jian Wang and Hai-Long He on 15 May 2015 from Dahaoping (24.9846°N, 98.7376°E; ca 1600 m a.s.l.), Mt. Gaoligong, Yunnan Province, PR China. Paratypes. Males SYS a003775/ CIB 116075, SYS a003777 and female SYS a003778, collected at the same time from the same locality as the holotype. Males SYS a007830–7831 and Females SYS a007829, 7832, collected by Jian Wang, Yu-Long Li and Yao Li on 9 June 2019 from Mengku Township (23.6586°N, 99.9847°E; ca 1980 m a.s.l.), Shuangjiang Lahu, Va, Blang and Dai Autonomous County, Yunnan Province, PR China. Etymology. The specific name “ occidentalis ” is a Latin adjective and means “western”, referring to the distribution of the new species in western Yunnan, which takes the westernmost distribution among all congeners. Common name. Western Yunnan Music Frog (in English) / Dian Xi Qin Wa (AEOiḪü in Chinese) Diagnosis. Nidirana occidentalis sp. nov. is placed in the genus Nidirana based on the morphological characteristics of the absence of the thumb-like structure on finger I, presence of well-developed dorsolateral folds, and the presence of suprabrachial glands in breeding males (Lyu et al. 2017), and is further assigned to the N. pleuraden group by the absence of lateroventral groove on all digits (Dubois 1992; Lyu et al. 2019). Nidirana occidentalis sp. nov. is distinguished from all known Nidirana congeners by the following combination of the morphological characteristics: (1) body medium-size and elongated, SVL 49.1 ± 3.3 (44.5–53.0, N = 5) mm in adult males and 58.8 ± 2.9 (55.6–61.3, N = 3) mm in adult females; (2) head relatively short, HDW/HWL 0.84 ± 0.05 in males and 0.86 ± 0.04 in females; (3) tympanum relatively small, TD/ED 0.81 ± 0.02 in males and 0.77 ± 0.02 in females (4) lateroventral grooves absent on every digit; (5) absence of supernumerary tubercles on hand; (6) tibio-tarsal articulation reaching at the eye; (7) heels just meeting; (8) posterior of dorsal skin rough with tubercles and spinules; (9) a pair of subgular vocal sacs in males; (10) one single nuptial pad present on the first finger in breeding males, nuptial spinules invisible; (11) suprabrachial gland large and smooth; (12) calling: 3–5 identical regular notes. Description of holotype: SYS a003776 (Fig. 6), adult male. Body elongated, SVL 47.5 mm; head relatively short, flat above; snout rounded in dorsal and lateral views, slightly protruding beyond lower jaw, longer than horizontal diameter of eye (SNT/ED 1.33); canthus rostralis distinct, loreal region concave; nostril round, closer to the snout than to the eye; a longitudinal swollen mandibular ridge extending from below nostril through lower edges, eye and tympanum to above insertion of arm; supratympanic fold absent; interorbital space flat, narrower than internasal distance (IND/IOD 1.29); pupil elliptical, horizontal; tympanum distinct, round, relatively small, and close to eye; pineal ocellus invisible; vomerine ridge present, bearing small teeth; tongue large, cordiform, notched behind. Presence of a pair of subgular vocal sacs, a pair of slit-like openings at posterior of jaw. Forelimbs moderately robust, lower arm 17% of SVL and hand 28% of SVL; fingers thin, relative finger lengths II <I <IV <III; tip of each finger not dilated and without lateroventral grooves; fingers free of webbing; presence of weak lateral fringes on inner and outer sides of fingers II, III and IV; subarticular tubercles prominent and rounded; absence of supernumerary tubercles; three elliptic, large, prominent and very distinct palmar tubercles. A single nuptial pad on the dorsal surface of first finger, nuptial spinules invisible. Hindlimbs relatively robust, tibia 51% of SVL and foot 82% of SVL; heels just meeting when hindlimbs flexed at right angles to axis of body; tibio-tarsal articulation reaching at the eye when hindlimb is stretched along the side of the body; toes relatively long and thin, relative lengths I <II <V <III <IV; tip of each toe not dilated and with- out lateroventral grooves; webbing moderate, webbing formula: I 2–2½ II 2–3 III 2½–3⅔ IV 4–2½ V; presence of lateral fringes on inner and outer sides of each toes, forming distinct dermal flap on the lateral edges of toes I and V; subarticular tubercles rounded, prominent; inner metatarsal tubercle elliptic; outer metatarsal tubercle absent, small and rounded; tarsal folds and tarsal tubercle absent. Dorsal skin of head and anterior body smooth, posterior dorsum of body rough with dense tubercles and horny spinules; developed dorsolateral fold from posterior margin of upper eyelid to above groin but intermittent posteriorly; flank smooth; a large and smooth suprabrachial gland behind base of forelimb, not prominent; dorsal surfaces of thigh and tibia with several longitudinal ridges and bearing spinules. Ventral surface of head, body, and limbs smooth; large flattened tubercles densely arranged on the rear of thigh and around vent. Coloration of holotype. Photos of the holotype in life were not taken and the coloration data is lacking. In preservative, dorsal surface of head and body dark brown; a longitudinal light mid-dorsal stripe extending from snout to vent; dorsolateral fold bicolor, upper part light brown and lower part black; flank light brown with irregular black spots; suprabrachial gland creamy. Dorsal forelimbs light brown; a longitudinal black stripe on the anterior surface of the forelimb; irregular black marks on dorsal surface of the forelimb; dorsal hindlimbs reddish brown with black crossbars on the thigh, tibia and tarsus; nuptial pad grey. Loreal and temporal regions dark brown; tympanum light brown. Lips and throat white; ventral surface of body and limbs creamy white; rear thigh tinged with pink; ventral hand and foot pale. Variations. Measurements of type series are given in Table 3 and photos of paratypes are shown in Fig. 7. All type series specimens were similar in morphology. Females are significantly larger than males, with the sexual size dimorphism of 83.5%. SYS a007830–7832 have several tubercles on the upper flank, not bearing spinules. Suprabrachial glands prominent in SYS a007830 (vs. not prominent in holotype SYS a003776 and paratype SYS a007831). The coloration of Nidirana occidentalis sp. nov. is variable, from yellowish brown, reddish brown to dark brown on dorsum; pineal ocellus invisible; a light mid-dorsal stripe edged with broad darker stripes extending from forehead to vent; black spots scatter on posterior dorsum. Dorsolateral fold bicolor, light color upper and darker lower part; flank varies from light brown to dark brown, with small black spots or large black patches. One black stripe in front of the base of forelimb; irregular dark marks on lateral forelimb; three to four dark brown or black crossbars on thigh, tibia and tarsus. Temporal region lighter color with a yellowish arc patch in SYS a007830, 7831; maxillary gland and shoulder gland white; upper ⅓ iris brownish white and lower ⅔ iris reddish brown. Ventral surface of body and limbs creamy white; several black spots on the edge of ventral belly and limbs in SYS a007832. Surface of throat darker; ventral hand and foot purplish brown. Distribution and ecology. Currently, Nidirana occidentalis sp. nov. is recognized from multiple localities in western Yunnan, all of which are situated to the west of the Red River (Fig. 1). This frog inhabits natural or artificial ponds surrounded by moist subtropical secondary evergreen broadleaved forests, and is common in its habitat, sympatric with Tylototriton shanjing Nussbaum, Brodie, and Yang, 1995, Nanorana yunnanensis (Anderson, 1879), and Zhangixalus puerensis (He, 1999). The adult males were heard calling in the water surface from May to July.Published as part of Lyu, Zhi-Tong, Chen, Yang, Yang, Jian-Huan, Zeng, Zhao-Chi, Wang, Jian, Zhao, Jian, Wan, Han, Pang, Hong & Wang, Ying-Yong, 2020, A new species of Nidirana from the N. pleuraden group (Anura, Ranidae) from western Yunnan, China, pp. 43-62 in Zootaxa 4861 (1) on pages 55-59, DOI: 10.11646/zootaxa.4861.1.3, http://zenodo.org/record/441453
Boulenophrys yingdeensis Qi & Lyu & Wang & Mo & Zeng & Zeng & Dai & Li & Grismer & Wang 2021, sp. nov.
No full textBoulenophrys yingdeensis sp. nov. Qi, Lyu, Wang & Wang Yingde Horned Toad / ying de jiao chan (Ȓ德fflDz) Figures 4, 5, 7B Chresonymy. Megophrys sp 4 (SYS a002100, 4721, 5447)— Liu et al. 2018 Holotype. SYS a002099 (Figures 4A, 7B), adult male, collected on 26 April 2013 by Run-Lin Li from Shimentai Nature Reserve (24.4435°N, 113.3034°E; ca 357 m a.s.l.), Yingde City, Guangdong Province, China. Paratypes. Eight adult specimens from the same locality as the holotype: female SYS a001563 collected on 23 April 2012 by Run-Lin Li; female SYS a004721 collected on 29 April 2016 by Ying-Yong Wang, Jian Wang and Zhi-Tong Lyu; female SYS a005447 and male SYS a005449 collected on 19 August 2016 by Zhi-Tong Lyu; male SYS a007114/ CIB 116084 collected on 20 June 2018 by Hong-Hui Chen, Jia-He Li and Jian Wang; male SYS a007405 and two females SYS a007406 and SYS a007407 collected on 20 August 2018 by Jian Wang. Etymology. The specific epithet yingdeensis refers to its type locality, Yingde City in northern Guangdong. Diagnosis. (1) Small body size, SVL 33.2–35.3 mm (34.2 ± 1.0, N = 4) in adult males and SVL 36.3–45.8 mm (40.7 ± 4.2, N = 5) in adult females; (2) snout rounded in dorsal view; (3) tympanum boundary clear, ED/TD 1.65– 1.95 in males, 1.48–2.09 in females; (4) vomerine ridge prominent bearing vomerine teeth; (5) margin of tongue rounded, not notched behind; (6) hindlimbs slender, heels overlapping or just meeting and tibio-tarsal articulation reaching forward between tympanum to posterior corner of eye; (7) tibia 0.46–0.48 of SVL and foot 0.61–0.67 of SVL in males, while tibia 0.44–0.46 of SVL and foot 0.61–0.66 of SVL in females; (8) toes without lateral fringes and with only rudimentary webbing; (9) presence of small, horn-like tubercle at the edge of upper eyelid; (10) dorsal skin smooth, a discontinuous “Y” or “X”-shaped ridge on the mid-dorsum, two discontinuous dorsolateral ridges on two side on the dorsum; (11) skin of flanks smooth with small conical tubercles; (12) single subgular vocal sac in males; (13) presence of villiform black nuptial spines on the dorsal surface of the first and second fingers in adult males. Comparisons. Comparative data of Boulenophrys yingdeensis sp. nov. from B. yaoshanensis sp. nov. and the other recognized members of the genus Boulenophrys are listed in Table 3. Having a smaller body size with SVL 33.2–35.3 mm in males, Boulenophrys yingdeensis sp. nov. differs from seven congeners whose SVL> 50 mm in males, including B. caudoprocta (81.3 mm in single male), B. jingdongensis (53.0– 56.5 mm in males), B. liboensis (60.5–67.7 mm in males), B. mirabilis (55.8–61.4 mm in males), B. omeimontis (56.0– 59.5 mm in males), B. sangzhiensis (54.7 mm in single male), and B. shuichengensis (102.0– 118.3 mm in males). Having relatively longer shanks with the heels overlapping or meeting when the flexed hindlimbs are held at right angles to the body axis, Boulenophrys yingdeensis sp. nov. can be easily distinguished from the following nine congeners, B. acuta, B. brachykolos, B. daoji, B. dongguanensis, B. insularis, B. nankunensis, B. obesa, B. ombrophila, and B. wugongensis (vs. all of which have relatively shorter shanks with the heels not meeting). Having vomerine teeth, Boulenophrys yingdeensis sp. nov. differs from B. acuta, B. angka, B. anlongensis, B. baishanzuensis, B. baolongensis, B. binchuanensis, B. binlingensis, B. boettgeri, B. brachykolos, B. caobangensis, B. congjiangensis, B. cheni, B. chishuiensis, B. daoji, B. huangshanensis, B. jiangi, B. kuatunensis, B. leishanensis, B. lini, B. lishuiensis, B. lushuiensis, B. minor, B. mirabilis, B. mufumontana, B. obesa, B. ombrophila, B. sanmingensis, B. shuichengensis, B. shunhuangensis, B. spinata, B. tuberogranulatus, B. wugongensis, B. wuliangshanensis, B. wushanensis, B. xiangnanensis, B. xianjuensis, B. yangmingensis, and B. yaoshanensis sp. nov. (vs. absence of vomerine teeth in these species). Having an unnotched tongue, Boulenophrys yingdeensis sp. nov. can be distinguished from B. baolongensis, B. binlingensis, B. boettgeri, B. cheni, B. hoanglienensis, B. huangshanensis, B. insularis, B. jingdongensis, B. jiulianensis, B. kuatunensis, B. liboensis, B. lushuiensis, B. minor, B. nanlingensis, B. omeimontis, B. qianbeiensis, B. sangzhiensis, B. sanmingensis, B. shuichengensis B. spinata, and B. tongboensis (vs. tongue notched posteriorly in these species). Lacking lateral fringes on toes, Boulenophrys yingdeensis sp. nov. differs from B. acuta, B. anlongensis, B. baishanzuensis, B. binchuanensis, B. boettgeri, B. congjiangensis, B. cheni, B. daiyunensis, B. daoji, B. jingdongensis, B. jinggangensis, B. liboensis, B. lini, B. lushuiensis, B. mirabilis, B. mufumontana, B. nanlingensis, B. omeimontis, B. palpebralespinosa, B. qianbeiensis, B. rubrimera, B. sangzhiensis, B. sanmingensis, B. shimentaina, B. shuichengensis, B. spinata, B. xiangnanensis, B. xianjuensis, and B. yangmingensis (vs. presence of lateral fringes on toes in these species); and from B. wushanensis (vs. presence of wide lateral fringes on toes in males while lacking in females). Having rudimentary webbing on toes, Boulenophrys yingdeensis sp. nov. differs from B. baishanzuensis, B. baolongensis, B. daweimontis, B. fansipanensis, B. frigida, B. huangshanensis, B. kuatunensis, B. lishuiensis, B. ombrophila, B. rubrimera, B. tongboensis, and B. wuliangshanensis (vs. absence of webbing on toes in these species); and from B. jingdongensis, B. palpebralespinosa, B. qianbeiensis, B. shuichengensis, and B. spinata (vs. presence of well-developed webbing on toes in these species). Description of holotype. Adult male. small body size, SVL 35.3 mm; head width slightly larger than head length, HWD/HDL 1.07; snout rounded in dorsal view, projecting, sloping backward to mouth in profile, protruding well beyond margin of lower jaw; top of head flat; eyes moderate in size, ED 0.30 of HDL, pupil vertical, near diamond-shaped; nostril oblique-ovoid; canthus rostralis well developed; loreal region slightly oblique; internasal distance slightly larger than interorbital distance; tympanum boundary clear, ED/TD 1.68; large ovoid choanae at the base of the maxilla; vomerine ridge prominent, vomerine teeth present, maxillary teeth present; margin of tongue rounded, not notched behind; presence of a single subgular vocal sac, a pair of slit-like openings at posterior of jaw. Radio-ulnar length 0.20 of SVL and hand 0.26 of SVL; hand without webbing, fingers without lateral fringes, relative finger length I <II <IV <III; tips of fingers slightly dilated, round; subarticular tubercles present; inner metacarpal tubercle observably enlarged and the outer one smaller; a single nuptial pad on the dorsal surface of the first and second fingers. Hindlimbs slender, tibio-tarsal articulation reaching forward the posterior corner of the eye when hindlimb is stretched along the side of the body; heels overlapping when the flexed hindlimbs are held at right angles to the body axis; tibia length 0.48 of SVL and foot length 0.67 of SVL; relative toe length I <II <V <III <IV; tips of toes round and slightly dilated; toes without lateral fringes and with rudiment of webs; ventromedial callous pad on toe I is round, on others are long strip shape; inner metatarsal tubercle long ovoid and the outer one absent. Skin of dorsum bearing small granules; skin of flanks smooth with small conical tubercles; a small, horn-like prominent tubercle on the edge of upper eyelid; clear supratympanic fold curving posteroventrally from posterior corner of eye to a level above insertion of arm; a discontinuous “X” shaped ridge on the mid-dorsum and two discontinuous dorsolateral ridges on two sides at the mid-back; sparse tubercles on the dorsal shank and thigh; ventral surface smooth; several tubercles on posterior hindlimbs; small pectoral gland closer to axilla; a single femoral positioned subequally distant from knees and cloaca on posterior surface of each thigh. Coloration of holotype in life. Dorsal surface of body olive-brown with an inverted brown triangular marking between eyes; an “X” shaped marking on the mid-dorsum. Forearms and hindlimbs with brown transverse bands. Supratympanic fold with a continuous white line; a dark vertical band below the eye, from the inferior margin of the eye to the upper lip. Ventral surface of throat and chest grayish brown with brown patches, an indistinct longitudinal stripe on surface of throat; a pair of dark brown longitudinal stripes scattered on surface of lateroventral flanks; ventral surface of body white with brown patches; ventral surface of limbs grayish brown with dark brown spots and blotches; ventral surfaces of hands and ventral surfaces of feet brown, tips of digits pale-brown; metacarpal tubercle and metatarsal tubercle reddish. Pectoral gland and femoral gland white. Iris yellowish brown. Coloration of holotype in preservative. Olive-brown faded to greyish brown dorsally. Triangular marking between eyes, “X” shaped marking on the mid-dorsum, transverse bands on dorsal forearms and hind limbs became indistinct. Color of ventral surface faded to greyish white all bands and spots became indistinct. Variation and sexual dimorphism. Measurement data of type series are listed in Table 5. Females (SVL 36.3–45.8 mm) are larger than males (SVL 33.2–35.3 mm). Presence of villiform black nuptial spines on the dorsal surface of the first and second fingers in adult males. Body coloration is quite variable, light brown, reddish brown, olive brown or dark brown dorsally (Figure 5). Distribution and ecology. Currently, Boulenophrys yingdeensis sp. nov. is known only from Shimentai Nature Reserve, Guangdong, China, and sympatric with B. shimentaina. All individuals were found in evergreen secondary forest, near lowland streams and nearbyleaf litter at elevations between 300– 400 m. Males perch and call on plant leaves from April to June, suggesting their breeding season corresponds to this period. Females were found on the forest floor and tadpoles were not observed.Published as part of Qi, Shuo, Lyu, Zhi-Tong, Wang, Jian, Mo, Yun-Ming, Zeng, Zhao-Chi, Zeng, Yang-Jin, Dai, Ke-Yuan, Li, Yuan-Qiu, Grismer, L. Lee & Wang, Ying-Yong, 2021, Three new species of the genus Boulenophrys (Anura, Megophryidae) from southern China, pp. 401-438 in Zootaxa 5072 (5) on pages 416-420, DOI: 10.11646/zootaxa.5072.5.1, http://zenodo.org/record/574897
Impact of smoking on response to TNF inhibitors in axial spondyloarthritis::methodologic considerations for longitudinal observational studies.
No full textThe British Society for Rheumatology Biologics Register in Ankylosing Spondylitis is funded by the British Society for Rheumatology, which has received funding for this study from Pfizer, AbbVie, and UCB. Dr. Zhao's work was supported by the Royal College of Physicians (John Glyn bursary) and the Royal Society of Medicine (Kovacs fellowship). Dr. Yoshida's work was supported by the pharmacoepidemiology program at the Harvard T. H. Chan School of Public Health (partially supported by training grants from Pfizer, Takeda, Bayer, and ASISA) and the Honjo International Scholarship Foundation. Dr. Solomon was supported by the NIH (grants P30-AR-072577 [VERITY] and NIH-K24-AR-055989).1Sizheng Steven Zhao, MD: University of Liverpool and Aintree University Hospital, Liverpool, UK, and Brigham and Women's Hospital, Boston, Massachusetts; 2Kazuki Yoshida, MD, PhD: Brigham and Women's Hospital and Harvard T. H. Chan School of Public Health, Boston, Massachusetts; 3Gareth T. Jones, PhD: University of Aberdeen, Aberdeen, UK; 4David M. Hughes, PhD: University of Liverpool, Liverpool, UK; 5Sara K. Tedeschi, MD: Brigham and Women's Hospital, Boston, Massachusetts; 6Houchen Lyu, MD: Harvard Medical School, Boston, Massachusetts, and General Hospital of Chinese PLA, Beijing, China; 7Robert J. Moots, MD, PhD, Nicola J. Goodson, MD, PhD: University of Liverpool and Aintree University Hospital, Liverpool, UK; 8Daniel H. Solomon, MD: Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
High-Throughput and Computational Study of Leaf Senescence through a Phenomic Approach
No full textLeaf senescence is influenced by its life history, comprising a series of developmental and physiological experiences. Exploration of the biological principles underlying leaf lifespan and senescence requires a schema to trace leaf phenotypes, based on the interaction of genetic and environmental factors. We developed a new approach and concept that will facilitate systemic biological understanding of leaf lifespan and senescence, utilizing the phenome high-throughput investigator (PHI) with a single-leaf-basis phenotyping platform. Our pilot tests showed empirical evidence for the feasibility of PHI for quantitative measurement of leaf senescence responses and improved performance in order to dissect the progression of senescence triggered by different senescence-inducing factors as well as genetic mutations. Such an establishment enables new perspectives to be proposed, which will be challenged for enhancing our fundamental understanding on the complex process of leaf senescence. We further envision that integration of phenomic data with other multi-omics data obtained from transcriptomic, proteomic, and metabolic studies will enable us to address the underlying principles of senescence, passing through different layers of information from molecule to organism.
© 2017 Lyu, Baek, Jung, Chu, Nam, Kim and Lim. This is an open-access
article distributed under the terms of the Creative Commons Attribution License
(CC BY). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms. © 2017 Lyu, Baek, Jung, Chu, Nam, Kim and Lim. This is an open-access
article distributed under the terms of the Creative Commons Attribution License
(CC BY). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms.
© 2017 Lyu, Baek, Jung, Chu, Nam, Kim and Lim. This is an open-access
article distributed under the terms of the Creative Commons Attribution License
(CC BY). The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution
or reproduction is permitted which does not comply with these terms.2
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