745 research outputs found

    Rory O\u27More

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    Courtship of Rory O\u27More and Kathleen Bawnhttps://egrove.olemiss.edu/kgbsides_uk/1961/thumbnail.jp

    Advancing precision medicine for asthma by focusing on type 2 cytokines and alarmins

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    Purpose of reviewAsthma is a heterogeneous disease encompassing distinct phenotypes and endotypes. Advances in elucidating the pathogenic role of type 2 (T2) cytokines and epithelial-derived alarmins have profoundly reshaped our understanding of airway inflammation in asthma. This review provides an updated perspective on how these mediators contribute to asthma pathobiology and examines their integration into emerging precision medicine strategies.Recent findingsBiologic agents targeting T2 cytokines (IL-4, IL-5, and IL-13) and alarmins (TSLP and IL-33) have demonstrated efficacy across a broad spectrum of severe asthma phenotypes. Recent evidence underscores the central role of alarmins in orchestrating both innate and adaptive immune responses within the airways. In parallel, the development of alarmin-associated molecular and clinical biomarkers is expanding patient stratification beyond traditional eosinophilic and allergic profiles.SummaryAdvancing our understanding of alarmins and T2 cytokines offers new opportunities to refine asthma endotyping, personalize therapeutic decisions, and pursue sustained disease remission. Future directions include the integration of multiomics, real-world evidence, and novel biomarker platforms to consolidate the next phase of precision medicine in asthma and optimize long-term disease modification strategies.</p

    Open Educational Resources

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    The production, licensing, use and re-use of learning objects accessible through open access distribution will be the focus of this presentation. Noted author and scholar Dr. Rory McGreal will share his knowledge of the increasing opportunities and challenges associated with the open access publication of learning materials

    Early Shakespeare, 1588-1594

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    Early Shakespeare, 1588–1594 draws together leading scholars of text, performance, and theatre history to offer a rigorous re-appraisal of Shakespeare's early career. The contributors offer rich new critical insights into the theatrical and poetic context in which Shakespeare first wrote and his emergence as an author of note, while challenging traditional readings of his beginnings in the burgeoning theatre industry. Shakespeare's earliest works are treated on their own merit and in their own time without looking forward to Shakespeare's later achievements; contributors situate Shakespeare, in his twenties, in a very specific time, place, and cultural moment. The volume features essays about Shakespeare's early style, characterisation, and dramaturgy, together with analysis of his early co-authors, rivals, and influences (including Lyly, Spenser and Marlowe). This collection provides essential entry points to, and original readings of, the poet-dramatist's earliest extant writings and shines new light on his first activities as a professional author

    The Behavioral Economics Guide 2014 (with a foreword by George Loewenstein and Rory Sutherland)

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    CONTENTS Foreword by George Loewenstein and Rory Sutherland Part 1 - The Basics - An Introduction to Behavioral Economics - Selected Behavioral Economics Concepts - References Part 2 - Resources - Books Read by 'Behavioral Economics Group' Members - Scholarly Journals with Behavioral Economics Content - Postgraduate Programs in Behavioral Economics and Behavioral/Decision Science Part 3 - Applied Perspectives Psychology and Behavioral Economics in Practice Appendix - Author and Contributing Organization Profile

    Pictures of You : Ten Journeys in Time

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    "The 20th century took history out of the hands of historians and gave it to photographers. in Pictures of You, best-selling author Rory MacLean (Stalin's Nose, Berlin:Imagine a City) draws on the world's largest archive of amateur photography to discover ten real lives, one from each decade of that century. The first killing of the Cold War, the dying hopes of a doomed aviator, the ghosts of Native America at Alcatraz, Chairman Mao's most timid lover; ten journeys in time, ten forgotten voices that echo down from the past, ten intimate stories that mirror our own." -- p. [2] of cover

    I See You: A Photo Album of People with Intellectual Disability

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    The casebook for the Institute for Imbecile Children, and the casebooks of the Grahamstown Lunatic Asylum constitutes one of South Africa’s largest archived records for people with intellectual disability (PWID) who were institutionalised from 1890 to 1920. In&nbsp;I See You&nbsp;I testify how the viewing of the casebooks’ content and photographs gave rise to a personal recognition of the personhood of the PWID. My testimony takes the form of poetry that is composed to honour and memorialise each individual person who is included in this album. Rory du Plessis is a Senior Lecturer in Visual Studies at the School of the Arts, University of Pretoria. He is a NRF-rated scholar, the co-editor of the academic journal,&nbsp;Image &amp; Text, and author of&nbsp;Pathways of Patients at the Grahamstown Lunatic Asylum, 1890 to 1907&nbsp;(Pretoria University Law Press 2020)

    The Memory Arts in Renaissance England: A Critical Anthology

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    This is the first critical anthology of writings about memory in Renaissance England. Drawing together excerpts from more than seventy writers, poets, physicians, philosophers and preachers, and with over twenty illustrations, the anthology offers the reader a guided exploration of the arts of memory. The introduction outlines the context for the tradition of the memory arts from classical times to the Renaissance and is followed by extracts from writers on the art of memory in general, then by thematically arranged sections on rhetoric and poetry, education and science, history and philosophy, religion, and literature, featuring texts from canonical, non-canonical and little-known sources. Each excerpt is supported with notes about the author and about the text's relationship to the memory arts, and includes suggestions for further reading. The book will appeal to students of the memory arts, Renaissance literature, the history of ideas, book history and art history
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