3,904 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Analysis of charge trapping and breakdown mechanism in high-K dielectrics with metal gate electrode using carrier separation
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Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Factors associated with the use of MF categories among donors and non-donors.
No full textFactors associated with the use of MF categories among donors and non-donors.</p
A "data sharing trust" model for rapid, collaborative science
No full textComplex datasets provide opportunities for discoveries beyond their initial scope. Effective and rapid data sharing andmanagement practices are crucial to realize this potential; however, they are harder to implement than post-publication access. Here, we introduce the concept of a "data sharing trust'' tomaximize the value of large datasets
Measurements of the dielectric properties of peripheral blood mononuclear cells and trophoblast cells using AC electrokinetic techniques
No full textThe separation of trophoblast cells from the maternal circulation could provide a valuable diagnostic tool for prenatal diagnosis of genetic abnormalities. This has been attempted using antibody methods, but due to non-specificity of the antibodies, maternal cell contamination remains a problem. We have investigated the potential of dielectrophoretic separation methods as a means of isolating trophoblast cells from mixed peripheral blood mononuclear cells. To determine the potential of this method the dielectric properties of trophoblast cells and mixed peripheral blood mononuclear cells were measured using dielectrophoretic crossover and single cell electrorotation methods. Both dielectrophoretic crossover data and electrorotation data gave an average specific membrane capacitance of the peripheral blood mononuclear cells of 11.5 mF m(-2). Trophoblast cells prepared using three different methods had a higher average specific membrane capacitance in the range 13-18 mF m(-2). The differences in capacitance between the cell types could be exploited as the basis of an AC electrokinetic-based system for the separation of trophoblast cells from peripheral blood mononuclear cells
Origin of the regolith-hosted HREE deposits in South China
No full textRare earth elements (REEs) become critical to our modern society due to their numerous high-technology applications. Currently, China is the dominant producer of the global REEs, especially for the more demanding and economically valuable heavy REEs (HREEs). The HREEs are mainly from regolith-hosted HREE deposits in South China. In these deposits, the HREEs are liberated from the parent rocks, mostly granites, during sub-tropical weathering and progressively accumulate in the weathering crusts through a series of eluviation and illuviation processes to form the economically valuable ore deposits.
Regolith-hosted HREE deposits are only related to HREE-enriched protoliths, mostly alkaline granites. Specifically, these granites have been subjected to extensive late-stage or later hydrothermal overprinting, which re-distributed and concentrated the REEs in several weathering susceptible minerals, including synchysite-(Y), gadolinite-(Y), hingganite-(Y), and yttrialite-(Y). Thermodynamic calculation shows that these minerals are susceptible to weathering and would efficiently release the HREEs they host during weathering. Therefore, pre-weathering metasomatism is essential for pre-concentration of the HREEs and thus for subsequent ore formation.
Exemplified by the largest deposit of this kind, the Zudong deposit in Jiangxi province, South China, the HREEs are largely enriched through adsorption on clay minerals, mainly kaolinite and halloysite. Also, precipitation of supergene chernovite-(Y) [REEAsO4] contributes to a certain amount of the enrichment. Contributions from Fe-Mn oxyhydroxides and organic matter are negligible. During incipient weathering, rapid decomposition of albite produced abundant short and stubby halloysite and microcrystalline kaolinite with low crystallinity, high specific surface area, and high cation exchange capacity. Therefore, these halloysite and kaolinite crystals have high adsorption capacity to adsorb the HREEs, probably as carbonate complexes at the interlayer positions. Under progressive weathering, halloysite and microcrystalline kaolinite are progressively transformed into large, well-crystallized, vermicular kaolinite “booklets”. In this process, dramatic decrease in the adsorption capacity occurred and hence, the adsorbed REEs would be desorbed in the shallow soils and transported by the soil solutions, likely as carbonate complexes based on thermodynamic circulation, to the deeper parts of the soil profiles, where abundant halloysite and microcrystalline kaolinite facilitate the REE adsorption. Arsenic behaves similarly to the HREEs and therefore, can be combined with the HREEs at the lower part of the soil profiles to form the supergene chernovite-(Y). Both REE adsorption and precipitation of chernovite-(Y) enrich the lower part of the soil profiles in the HREEs. Continuous operation of this eluviation-illuviation process eventually causes the formation of world-class regolith-hosted HREE deposits in South China.published_or_final_versionEarth SciencesDoctoralDoctor of Philosoph
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