11,957 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Get PDFThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Exploiting HBIM for Historical Mud Architecture: The Huaca Arco Iris in Chan Chan (Peru)
No full textThe construction technique of raw earth, which has always been in use in most of the world,
has left large monuments or architectural complexes to cultural heritage that need special attention due to the notable vulnerability of the material. A convenient way to deal this threat, besides physical intervention, is by using an information system, such as HBIM (Heritage Building Information
Modeling), as a tool for damage assessment and conservation planning. This paper reports on its
application in an archaeological setting, in particular, on the Huaca Arco Iris, a religious building of
the old city of Chan Chan (Peru), the largest monumental complex in mud on the American continent.
The study is part of the bilateral international project between the Consiglio Nazionale delle Ricerche
(CNR) and the Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (CONCYTEC) in
the use of HBIM for the prediction of possible natural or anthropogenic damages to buildings in
raw mud. Exploiting the data coming from the direct and indirect analyses, a dedicated ontology
is built to guide the management of these data within the information system. The creation of an
HBIM system for the archaeological domain, based on the trinomial data–information–knowledge, is
presented and validated. Following this approach, a customizable HBIM has been created with the
3D model of the spatial entities of the Huaca. As a result, the semantic relationship of an external wall,
taken as the benchmark test of our experiment, with the contained bas-relief and the conservation
cover is tested
Assessing celebrity endorsement effects in China : a consumer-celebrity relational approach
No full textAuthor name used in this publication: Chan, Kimmy W.2011-2012 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedPublisher permissio
Monolayers of diphenyldiacetylene derivatives: Tuning molecular tilt angles and photopolymerization efficiency via electrodeposited Ag interlayer on Au
No full textEfficacy of risperidone versus olanzapine in schizophrenic patients poorly responsive to only one line of conventional antipsychotics: a randomized, rater-blind, active-control study
No full textTiming of subduction zone metamorphism during the formation and emplacement of Troodos and Baer-Bassit ophiolites: insights from Ar-40-Ar-39 geochronology
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< Canchan > y no < Chan chan >: definitivamente quechumara y no quingnam
No full textEn la presente nota nos proponemos discutir los cuestionamientos y objeciones que se hacen (cfr. Urban, 2022) a nuestra propuesta etimológica ofrecida en Cerrón-Palomino (2020b), en la que abogamos por la procedencia quechumara del nombre <Chanchán> sobre la base de evidencias contundentes, descartando filiaciones hipotéticas que se han venido postulando, ya sea por meras inferencias topolingüísticas, ya por desinformación onomástica, o incluso por la falta de una necesaria pesquisa documental y archivística. En tal sentido, nos ratificamos en la etimología propuesta, que nos parece lo suficientemente explícita y rigurosa. En función de ello, nuestro artí- culo procederá, paso a paso, examinando y rebatiendo los puntos que son cuestionados y supuestamente redargüidos (véase Urban, 2022), procurando demostrar que la propuesta etimológica que ofreciéramos previamente, lejos de ser “rotundamente rechazada” (p. 103), por “cuestionable” (p. 106), “inadecuada” (p. 107), “forzada” (p. 117), etc., se mantiene incólume, como resultado del escrutinio riguroso de los datos analizados. Tales puntos tienen que ver con: (a) la filiación de la voz protoquechua (PQ)*kanĉa, que no sería compartida con el protoaimara (PA); (b) la postulación de la terminación -n del topónimo como reflejo del posesivo o adjudicador aimara -ni, que sería un artificio; (c) el empleo del dígrafo culto <ch> en la onomástica andina, que Matthias Urban considera inusitado; (d) la asociación etimológica entre <Canda> y <Chanchan>, que el mencionado autor asume igualmente gratuita; (e) el flaco recurso de la reduplicación de radicales monosilábicos, que argumentaría en favor del topónimo <Chan Chan>, asumido como de filiación idiomática quingnam; y (f) el supuesto “rol conquistador” y difusor del aimara y el quechua que, según Urban (2017), habrían ejercido, de acuerdo con mis planteamientos, en la costa norte peruana.In the present article I discuss the reservations and objections held (cfr. Urban, 2022) against my etymological proposal offered in Cerrón-Palomino (2020b), where I argue, based on overwhelming evidence, that the noun <Chanchán> is of Quechumaran origin, thereby discarding hypothetical alternatives put forward due to mere topo-linguistic inferences, the lack of onomastic acquaintance, or even the absence of an essential archival and documentary inquiry. In this respect, I stand by the etymology I proposed, which is explicit and rigorous to the scrutiny of any thorough specialist in the field. Thus, my article will examine and refute, on a step-by-step basis, the arguments that are questioned and allegedly counter-argued (see Urban, 2022), in order to demonstrate that my original proposal is not “categorically rejected” (p. 103), “questionable” (p. 106), “inadequate” (p. 107), “forced” (p. 117), etc., but is rather the result of an objective and unprejudiced endeavor. The arguments in question are (a) the filiation of the Protoquechuan (PQ) term *kanĉa, allegedly not shared with Protoaymaran (PA); (b) the proposal of the -n ending of the toponym as a reflection of the Aymaran possessive or adjudicator -ni, depicted as an artifice; (c) the use of the cult digraph <ch> in Andean onomastics, characterized as unusual; (d) the contrived etymological association between <Canda> and <Chanchan> that the aforementioned author readily accepts; (e) the meager resort to the reduplication of monosyllabic roots, purportedly conveying the <Chan Chan> toponym a Quingnam filiation; and (f) the pretended “conquering and spreading role” that Aymara and Quechua had in the north Peruvian coast, which Urban (2017) attributes to my proposal
Copper(II) Fluoride a New Efficient Promoter of Chan-Lam-Evans Coupling
Get PDFThe Chan-Lam-Evans coupling is the copper(II) acetate promoted reaction of phenols and boronic acids producing diaryl ethers. In this paper a modification of the original reaction is reported using copper(II) fluoride reagent which gives higher yields than copper(II) acetate. The most significant increase in yield was observed in formation of sterically hindered phenols. We hypothesize that fluoride ions help to cleave the boron-carbon bond. The novel method is suitable for selective, efficient and economical synthesis of diaryl ether compounds under mild conditions
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