4,425 research outputs found
A novel methodology independent of fermentation rate for assessment of the fructophilic character of wine yeast strains
No full textThe yeast Saccharomyces cerevisiae has a fundamental role in fermenting grape juice to wine. During alcoholic fermentation its catabolic activity converts sugars (which in grape juice are a near equal ratio of glucose and fructose) and other grape compounds into ethanol, carbon dioxide and sensorily important metabolites. However, S. cerevisiae typically utilises glucose and fructose with different efficiency: glucose is preferred and is consumed at a higher rate than fructose. This results in an increasing difference between the concentrations of glucose and fructose during fermentation. In this study 20 commercially available strains were investigated to determine their relative abilities to utilise glucose and fructose. Parameters measured included fermentation duration and the kinetics of utilisation of fructose when supplied as sole carbon source or in an equimolar mix with glucose. The data were then analysed using mathematical calculations in an effort to identify fermentation attributes which were indicative of overall fructose utilisation and fermentation performance. Fermentation durations ranged from 74.6 to over 150 h, with clear differences in the degree to which glucose utilisation was preferential. Given this variability we sought to gain a more holistic indication of strain performance that was independent of fermentation rate and therefore utilized the area under the curve (AUC) of fermentation of individual or combined sugars. In this way it was possible to rank the 20 strains for their ability to consume fructose relative to glucose. Moreover, it was shown that fermentations performed in media containing fructose as sole carbon source did not predict the fructophilicity of strains in wine-like conditions (equimolar mixture of glucose and fructose). This work provides important information for programs which seek to generate strains that are faster or more reliable fermenters.T. Liccioli, P. J. Chambers, V. Jirane
Illustrating potential efficiency gains from using cost-effectiveness evidence to reallocate Medicare expenditures
No full textThis article is available open access through the publisher’s website at the linke below. Copyright @ 2013, International Society for Pharmacoeconomics and
Outcomes Research (ISPOR).This article has been made available through the Brunel Open Access Publishing Fund.Objectives - The Centers for Medicare & Medicaid Services does not explicitly use cost-effectiveness information in national coverage determinations. The objective of this study was to illustrate potential efficiency gains from reallocating Medicare expenditures by using cost-effectiveness information, and the consequences for health gains among Medicare beneficiaries.
Methods - We included national coverage determinations from 1999 through 2007. Estimates of cost-effectiveness were identified through a literature review. For coverage decisions with an associated cost-effectiveness estimate, we estimated utilization and size of the “unserved” eligible population by using a Medicare claims database (2007) and diagnostic and reimbursement codes. Technology costs originated from the cost-effectiveness literature or were estimated by using reimbursement codes. We illustrated potential aggregate health gains from increasing utilization of dominant interventions (i.e., cost saving and health increasing) and from reallocating expenditures by decreasing investment in cost-ineffective interventions and increasing investment in relatively cost-effective interventions.
Results - Complete information was available for 36 interventions. Increasing investment in dominant interventions alone led to an increase of 270,000 quality-adjusted life-years (QALYs) and savings of $12.9 billion. Reallocation of a broader array of interventions yielded an additional 1.8 million QALYs, approximately 0.17 QALYs per affected Medicare beneficiary. Compared with the distribution of resources prior to reallocation, following reallocation a greater proportion was directed to oncology, diagnostic imaging/tests, and the most prevalent diseases. A smaller proportion of resources went to cardiology, treatments (including drugs, surgeries, and medical devices, as opposed to nontreatments such as preventive services), and the least prevalent diseases.
Conclusions - Using cost-effectiveness information has the potential to increase the aggregate health of Medicare beneficiaries while maintaining existing spending levels.The Commonwealth Fun
Past veterinarians in South Africa
No full textAn alphabetical list containing short biographies of all deceased South African veterinarians up to 1990.[compiled by] P.J. (Bill) PosthumusVolume 1: AL -- Volume 2: M-ZAlso available in print http://137.215.9.20/record=b1893606ab2013ab201
Open brief aan den WelEdel. Gestr. Heer P.J. Joubert
No full textleyds-70-7201.pdf created from original pamphlet in the WJ Leyds Collection held in the Africana Section of the Stellenbosch University Library and Information Service.Dutch open letter to P.J. Joubert concerning a railroad concession granted to the author and two of his friends in 1885
Design, Modeling and Simulation of a 52MHz MEMS Gyroscope Device in 1.5um SOI
No full textIn this thesis , a simulation model of a MEMS gyroscope is presented. The model enables mode matching and analysis of the dynamic behavior of a gyroscope. Furthermore, the model allows the optimization the design parameters of the gyroscope. The simulated gyroscope operates at a frequency of 52MHz with amplitudes of 10nm and quality factor of 50,000. Finally, the drive mode measurements are presented at different bias voltages.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Het gemeentelijk Investeringsraadsel: Het verband tussen gemeentelijke investeringen en lokale welvaartsontwikkeling
No full textDit proefschrift gaat over de vraag in hoeverre in Nederland de lokale welvaartsontwikkeling wordt bepaald door de gemeentelijke investeringsinspanning. Op project niveau is meestal wel het een en ander bekend over de maatschappelijke effecten, maar over de impact van de totale investeringsinspanning ontbreekt zowel fundamentele als toepasbare kennis. Het is een raadsel dat nog opgelost dient te worden. De doelstelling van dit proefschrift is daaraan een bijdrage te leveren.Housing System
Coupled thermo–hydro–mechanical processes for the Dutch radioactive waste repository
No full textDisposal of spent nuclear fuel and long lived radioactive waste in deep clay geological formations is one of the promising options worldwide. In this concept of the geological disposal system, the Boom Clay is considered as a potential host rock when designing a generic waste repository in the Netherlands. For design and evaluation of a repository for geologic disposal of nuclear wastes one of its principal concern is the thermal loading. High-level radioactive waste and spent fuel generate considerable amounts of heat. When those waste types are disposed in a geological repository the elevated thermal effect on the behaviour of soils surrounding nuclear waste disposal give rise to change in hydraulic and mechanical properties is a significant factor for repository design. Understanding these time-dependent phenomena processes in relation to both the effects of pore water dissipation and of the thermal expansion is essential for reliably assessing repository performance and evaluating the safety case. This paper presents some of the investigation on the thermal processes with emphasis on the coupled Thermo-Hydro- Mechanical (THM) processes for the disposal concept of a radioactive waste disposal facility, in Boom Clay at a depth of about 500m.Geo-engineerin
Probabilistic performance assessment of a deep tunnel for a radioactive waste repository in French COx claystone
No full textA preliminary probabilistic study of the stability of a circular drift excavated for a radioactive waste repository in the French Callovo-Oxfordian claystone is presented and discussed. An analytical mechanical model assuming isotropic elastic behaviour and linear plastic softening was used. Particular emphasis here is placed on the uncertainty of mechanical property values. The test results from several laboratories showed considerably variable property values and they have been interpreted statistically in this investigation. The obtained statistical results were used in a Monte Carlo framework. The performance of the drift was evaluated in terms of the probability of threshold exceedance in the extent of the plastic zone.Geo-engineerin
Achteraf bekeken: Architectuur in Suriname 1951 tot 1969: Bouwwerken ontworpen door ir. P.J. Nagel (1921-1997)
No full textDit boek bestaat hoofdzakelijk uit foto’s van bouwwerken in Suriname, ontworpen door ir. Peter Jacobus Nagel in de periode 1951-1969. Ingenieur P.J. Nagel is afgestudeerd aan de Technische Hogeschool Delft. In dit boek wordt beschreven het leven van Nagel: zijn studietijd, eerste werkkring op Aruba, leven en werken als zelfstandig architect in Suriname van 1951 tot 1963 en tot slot zijn activiteiten in- en vanuit Nederland
Cementbetonnen plaatbekledingen op oevers en dijken, bundeling van artikelen uit de vakpers 1990-1991
No full textCUR; Proefproject: Open colloidaal beton a/s dijkbekleding; PT civiele techniek, april 1990. Burger, A.M., Eversdijk, P.J. en Hendriksma, A.M.; Open cementbeton toegepast a/s bekleding voor dijken; Zeewering Breskens, proefproject voor colloidaal beton; Land + Water, mei 1990. Burger, A.M., Eversdijk, P.J. en Hendriksma, A.M.; Colloidaal beton weerstaat zware storm en hoge golven; De praktijk van open cementbeton a/s Plaatbekleding; Land + Water, juni 1990. CUR; Cementbetonnen plaatbekledingen op dijken; Proefprojecten CUR; Civiele Techniek, No4, 1990. Vrieze, C.G. de; Betonnen dijken, groen a/s gras; Proeven met colloidaal beton voor begroeide rivierdijken; Land + Water No.6, juni 1991. Eversdijk, P.J. en Fase, A.G.; Breuksteen met colloidaal beton pakt rivierdijken goed in; Proefproject Opijnen in Julianakanaal; Land + Water No. 7/8, augustus 1991. Rijke, W.G. de en Burger, A.M.; Cementbetonnen plaatbekledingen op dijken en oevers; Praktische ontwerpmethode (1); Civiele Techniek, jaargang 46, No.3, 1991. Rijke, W.G. de en Burger, A.M.; Cementbetonnen plaatbekledingen op dijken en oevers theoretisch waterdicht; Praktische ontwerpmethode (2); Civiele Techniek, jaargang 46, No.4, 1991. CUR; oemonstratieproject open colloidaal beton Noordoostpolder; Civiele Techniek, No.3, 1991
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