1,722,323 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The role of ODV structural proteins in baculovirus replication
Full text linkBaculoviruses are arthropod-specific viruses with a circular, double-stranded DNA genome (80-180 kb). Two structural forms are produced during virus replication, comprising budded virus (BV) and occlusion-derived virus (ODV). The BV is produced from 12 hours post infection (hpi) and spreads the infection from tissue to tissue within the host. The ODV is formed 20 hpi and enveloped within occlusion bodies (OBs). The aim of this project was to elucidate the mechanisms involved in ODV production by deleting putative genes involved in oDV, but not BV production. A secondary aim of the project was to determine whether removing these genes improved the quantity/quality of recombinant proteins produced by baculovirus expression vectors. Genes for ODV structural proteins were selected and individual gene deletion mutants were generated. Three of these (Δ orf79 , Δodv-e28, and Δodv-ec43) unexpectedly prevented virus replication in insect cell culture. orf79 and odv-ec43 were demonstrated to be essential genes as viability could be restored after a rescue assay with the target gene, whereas the loss of infectivity in t-.odv-e28 probably resulted from an effect on helicase, an essential neighbouring gene. j Three deletion mutant viruses (AcΔcg30, AcΔodv-e66 and AcΔ.odv-e56) that were viable in insect cell culture were studied for any effect on ODV production and OB formation using bioassays and electron microscopy imaging. Deletion of odv-e66 and odv-e56 both negatively affected oral infectivity of OBs, whereas the deletion of cg30 increased infectivity. The electron microscopy imaging of the OBs of these deletion mutant viruses identified abnormalities for AcΔcg30POl'+ and ActΔodv-e56po1+. AcΔcg30P01+ OBs seemed to be degraded due to deformities in the polyhedron envelope (PE) while AcΔodv-e56po,+ OBs were surrounded by another protein structure but had no apparent difference in structure or ODV packaging compared to the parental virus. The formation of BV by the pif3 deletion mutant virus was reduced, although plaques were still formed in titrations of infectivity. BV production could only be restored by a rescue assay with pif3, suggesting PIF3 may have another function that is yet to be fully characterized. The deletion of orf118/pif1 and pif2 were analysed for their effect on recombinant protein production expressed from the polh promoter, using activity assays. Both the deletion of orf118/pif1 and pif2 caused a reduction in the intracellular protein, beta-galactosidase. However, the deletion of pif2 did not impact the expression of urokinase, an extracellular recombinant protein. This project also investigated through mutagenesis the possible role of the PIF1 RGD motifs in oral infection of larvae. The initial findings suggest that the PIF1 RGD motifs functional role is not very clear and indicate that PIF1 RGD motifs are not involved in integrin binding but could mediate other interactions during viral entry into the midgut cells. While the mechanism involved in the production of ODV was not elucidated, a number of interesting observations have been made about the targeted structural components of the ODV that were investigated, which could aid the understanding of the major transition from BV to ODV production during the baculovirus infectionEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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