22 research outputs found

    Close-up of a specimen of belladonna lilies (Amaryllis belladonna), ca.1920

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    Photograph of a close-up of a specimen of belladonna lilies (Amaryllis belladonna), ca.1920. Pictured against a dark background. Seven blossoms can be seen, and portions of the two stalks.; "This group consists of one deciduous plant, A. belladonna (Belladonna Lily; Naked Lady Lily), which is native to southern Africa and has been naturalized in some areas of the U.S. This plant grows from a true bulb to 2 or 3 feet high. It produces long, slender leaves in the spring, which die back in early summer. Then, in late summer, 2- to 3-foot, red tinged stalks arise each bearing up to a dozen, aromatic blossoms. The 4- to 6-inch, trumpet-shaped flowers may be white, red, rosy red, or pink and are excellent as cut flowers, lasting for about a week. *Note that Belladonna Lilies are poisonous if eaten." -- unknown author

    Comparative merits of stramonium, belladonna, genoscopolamine, and hyoscine, in the treatment of post-encephalitic Parkinsonism

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    The following thesis is based on a series of researches carried out by the author at the London County Mental Hospital, West Park, Epsom, on the drug treatment of the post -encephalitic Parkinsonian state, in a series of 65 cases.The remedies employed were directed towards the control, and relief, of those distressing manifestations, which follow an attack of encephalitis lethargica, and which form the Parkinsonian syndrome.The object of this thesis is to draw a comparison between the following drugs : - hyoscine hydrobromide, tincture of stramonium, tincture of belladonna, and genoscopolamine hydrobromate, in their effect on the various manifestations of post-encaphalitic Parkinsonism

    "Victim of the Past, The present and The possible Future" Belladonna by Dasa Drndic

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    The discussion about the war plays not only a central role in German literature of the 20th century, but it also holds a very important and indispensable place in Croatian literature, considering the events of the previous war on Croatian territory (i.e. former Yugoslavia) around 1990. Wars are, as Carsten Gansel says: “similar to revolutions, fundamental disturbances of the social system status, a social ‘state of emergency’” (Gansel 2012: 9-12). Literature as a form of ‘self-observation of societies’ (H. Böhme 1998: 476–485) constitutes a medium, in which ‘fault conditions’ (Gansel 2012: 9-12), caused by wars, can be thematized. The “dualism of offender and victim, observer and combatant, army and civil population, rulers and subjects” (also in socio-political everyday life), find expression in literature, by processing it literarily and discussing it.In her work, Daša Drndić thematizes exceedingly controversial and lively past and current war discourses in socio-cultural context from the perspective of the past, as well as of the present. Her work, i.e. her texts, can be considered as a cultural form of expression, which “in symbolic presentation provides individual, and/or generation-specific reminiscence of the collective memory[1]” (Gansel 2011:11).Daša Drndić discusses openly and without reservation already controversially conducted discourses about the Second World War, Holocaust, escape, expulsion, camp and destruction, especially after 1945, as well as the roles of the offender and victim not only in the Second World War and the ‘Yugoslavian war’ (civil war, fatherland war) from an – let’s say – own perspective. In her most recent work Belladonna (2012)[2], she even goes one step further, by thematizing and questioning the present everyday life interwoven with experiences, events and stories from the past through illness, suffering, dying, death and being a victim of diverse socio-political and socio-cultural systems until it becomes unbearable.Daša Drndić, a retired professor of Modern English Literature and author of several award-winning novels, with residence in Rijeka and several study and research periods amongst others in the USA, Canada, Serbia, Germany, Switzerland and Italy, born 1946 in Zagreb, is, besides Slavenka Drakulić, Dubravka Ugrešić and Ivana Sajko, one of the most read and most committed (as well as the most controversial) author of contemporary Croatia.[1] Collective stories are based on collective memory, which – as opposed to the individual memory - is developed in social interdependency of members of a collective. The individual memory, which is formed by the collective memory of the social-historical environment, builds, however, individual stories. See:Gansel/Kaulen 2011.[2] All quotations of the novel Belladonna (2012) will be marked/quoted only with ´Belladonna´ and the page number. All quotations have been translated from Croatian into German by the author of this article, as a German Translation of the novel Belladonna is not yet available. The novel Sonnenschein, which is on a paratextual level very important for this study, is currently being translated from Croatian into German (status: 29.9.2014). The German translation will be presented at the book fair in Leipzig in 2015.

    Solatro furioso, Ribes

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    1. Nome scientifico: Atropa belladonna L. (Solanaceae) Nome attuale: Belladonna 2. Nome scientifico: Ribes rubrum L. (Saxifragaceae) Nome attuale: Ribes Ross

    The (new) uses of enchantment: a framework for co-creating social purpose advertising with young people

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    Young people who have encountered challenging experiences are often motivated to assist others in similar situations. However, they frequently feel disempowered by co-creation workshops that are dominated by adult-centric methods (Cutter-Mackenzie-Knowles and Rousell, 2020) and "tokenistic" (McMellon and Tisdall, 2020, p.160) activities requiring advanced linguistic skills (Bragg, 2010). The onto-epistemologies of young people encompass emotion, play, enchantment, and imagination (Dunn and Mellor, 2017, p.288; Harris, 2013, p.40; Steele, 2013, p.540). For youth co-creation to thrive, methodologies must align with these realms of knowledge (Ergler, 2017, p.240). Such approaches are urgently needed (Dunn and Mellor, 2017, p.288).This research asks how facilitators can engage young people’s knowledge domains of imagination and enchantment to uncover insights and creative ideas and what project methodologies optimise young people’s agency to co-create social-purpose campaigns. The study employs two case studies in which teenagers co-create national-scale campaigns about loneliness and image-based abuse. Co-creators describe the workshops as like journeying through a parallel universe, referring to transformations, transmutations, and resurrections with fairytale- or fantastical qualities. The theme of ‘enchantment’ links these experiences. Therefore, the study draws on play and depth-hermeneutics methods and a theoretical lens of enchantment to understand the co-creators’ experiences of a set of social-purpose advertising workshops led by the author. It provides a ‘Framework for Enchantment’ comprising project designs, tools, guidelines for reflexive and emergent facilitation, and a collective leadership model. This framework addresses critical gaps in the co-creation literature regarding systems to engage young people’s imaginative, symbolic, emotional and enchanted domains of knowledge, techniques to support young people in synthesising collective creative insights and ideas, and project designs which support young people’s agency and meaningful engagement. Whilst this has been tested through social purpose advertising development, it is potentially relevant to the wider design community, including design futures, product and service design, experience design, play design and education design.</p

    Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization

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    © 2018, The Author(s). cc-byTropinone is the first intermediate in the biosynthesis of the pharmacologically important tropane alkaloids that possesses the 8-azabicyclo[3.2.1]octane core bicyclic structure that defines this alkaloid class. Chemical synthesis of tropinone was achieved in 1901 but the mechanism of tropinone biosynthesis has remained elusive. In this study, we identify a root-expressed type III polyketide synthase from Atropa belladonna (AbPYKS) that catalyzes the formation of 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid. This catalysis proceeds through a non-canonical mechanism that directly utilizes an unconjugated N-methyl-Δ1-pyrrolinium cation as the starter substrate for two rounds of malonyl-Coenzyme A mediated decarboxylative condensation. Subsequent formation of tropinone from 4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoic acid is achieved through cytochrome P450-mediated catalysis by AbCYP82M3. Silencing of AbPYKS and AbCYP82M3 reduces tropane levels in A. belladonna. This study reveals the mechanism of tropinone biosynthesis, explains the in planta co-occurrence of pyrrolidines and tropanes, and demonstrates the feasibility of tropane engineering in a non-tropane producing plant
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