737 research outputs found
A Conversation about Aliens, AIs and Jack Benny
No full textPresented on March 14, 2019 at 11:00 a.m. in the Crosland Tower, 7th floor reading room.Jack McDevitt is a former English teacher, naval officer, Philadelphia taxi driver, customs officer and motivational trainer. His work has been on the final ballot for the Nebula Awards for 12 of the past 13 years, and he holds 16 nominations in total. His first novel, The Hercules Text, was published in the celebrated Ace Specials series and won the Philip K. Dick Special Award. In 1991, McDevitt won the first $10,000 UPC International Prize for his novella, "Ships in the Night." The Engines of God was a finalist for the Arthur C. Clarke Award, and his novella, "Time Travelers Never Die," was nominated for both the Hugo and the Nebula awards.Runtime: 60:59 minutesThe Georgia Tech Library is proud to host Nebula Award-winning author Jack McDevitt in the Seventh Floor Reading Room Thursday, March 14 for “A Conversation about Aliens, AIs and Jack Benny with Sci-Fi Author Jack McDevitt
[Photograph of Benny Barnes]
No full textPhotograph of Benny Barnes, taken portrait style. He poses in dark clothing, his shirt open slightly revealing his chest and a chain necklace. Rings adorn two fingers on his left hand
Benny to Mr. H. B. Smith, 30 September 1962
No full textBenny states we are okay and says things in Oxford are a mess. Asks recipients to call Bob\u27s mother.https://egrove.olemiss.edu/west_union_tel/1134/thumbnail.jp
Henri Temianka Correspondence; (benny)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/1144/thumbnail.jp
[Letter to "Bo" Mildred, "Benny" Connie and "Bill"]
No full textLetter from unknown author to "Bo" Mildred, "Benny" Connie and "Bill" telling them of the new occurrences in his life and work
Regulation of the mouse T cell receptor repertoire
No full textIn both mice and humans, as they age, the thymus involutes and decreases in size
and function, with the majority being replaced by adipose tissue, and the number of
lymphocytes and thymic epithelial cells (TEC) decline. The first aim of this thesis was
to characterise the differences in T cell receptor (TCR) repertoires between foetal,
young adult and ageing mice by next generation sequencing the recombined TCRa
and TCRb gene transcripts expressed in WT thymocytes and peripheral T cells.
Wildtype (WT) E18.5 embryos was dissociated and FACS-sorted for CD69- doublepositive (DP), CD69+DP, SP4 (CD3+CD4+) and SP8 (CD3+CD8+) T cells. In adult
mice (4 weeks and 1 year old WT mice), the thymocytes were FACS-sorted for CD3-
DP, CD3+DP, SP4 and SP8 T cells. Furthermore, the combined lymph nodes and
spleen were FACS-sorted for naive CD4 and CD8, effector memory CD4 and CD8,
and central memory CD4 and CD8.
Analysis of TCR repertoires revealed greater clonality of peripheral effector memory
CD4 and CD8 and central memory CD8 aged repertories compared to young adult.
Using ecological estimators of diversity, TCR diversity was found to modestly
decrease with age, especially in b chain repertoires from CD3+DP and SP8
thymocytes, and in effector memory CD4 and CD8, along with central memory CD8
populations. The diversity of b chain repertoires was more affected than a chain,
suggesting that there are age-dependent changes to the rearrangement process of b
chains. As mice aged, there was a divergence of sharing in complementary
determining region 3 (CDR3) repertoires that could be due to a result of environmental
influences to the repertoire. Taken together, the data in this thesis show that the TCR
remains highly diverse in aged mice in both thymus and periphery, challenging the
idea that thymic rejuvenation is required to produce a good immune response in the
elderly.
When comparing foetal repertoires to adult repertoires, they were found to be less
diverse and contain less information with higher sharing of CDR3 sequences than
young adult and aged repertoires. Foetal repertoires were also observed to display
biases in TRAV, TRAJ and TRBV gene usage depending on the chromosomal location
of the genes. These results point towards the process of rearrangement being more
programmed in foetal repertoires.
The Hedgehog (Hh) signalling pathway regulates T cell development in the thymus by
regulating differentiation, survival and proliferation of the earliest DN thymocytes and
reducing TCR signal strength at later stages of development. The second aim of this
thesis was to investigate the impact of these changes in TCR signal strength induced
by Hh signalling on TCR repertoire selection by next generation sequencing the
repertoires from CD3-DP, CD3+DP, SP4 and SP8 thymocyte populations in lckGli2∆N2-transgenic, lck-Gli2∆C2-transgenic, Shh+/-
, Gli3+/-
, Shhfl/flFoxN1-Cre, and
Gli3fl/flFoxN1-Cre compared to wildtype or control mice.
The inhibition of Shh signalling in the lck-Gli2∆C2-transgenic mouse significantly
reduced the diversity and increased the clonality of the TCR repertoire in the SP4
population and altered the variable joining (VJ) gene usage in comparison to the
wildtype. On the other hand, increasing the Hh signal to above wildtype levels in the
lck-Gli2∆N2-transgenic increased the diversity of the TCR repertoire in both the CD3-
DP population. Heterozygous deletion of Gli3 enriched the TCR diversity and
increased sharing of sequences. Conditional deletion of Shh from TEC cells affected
the clonality of SP4 cells and VJ gene usage. Taken together, the work in this thesis
shows how the TCR repertoire can be altered through changes in TCR signal by
modulating Hh signalling
Optimal capacity adjustment for supply chain control
No full textThesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2004.Includes bibliographical references (p. 117-124).This research attempts to answer the questions involving the time and size of capacity adjustments for better supply chain management. The objective of this research is to analytically determine simple structures to adjust capacity that require minimal computational resources and are relatively easy to implement. The research focuses on manufacturing companies that operate a make-to-order environment in which there is no inventory of finished products. The model used in the analysis is make to order with lost sales. The optimal capacity planning problem is formulated as a dynamic program that is solved analytically using Karush-Kuhn-Tucker conditions. The technique is used to derive optimal structures for three types of capacity planning: (a) making adjustment to aggregate capacity, (b) using overtime and making adjustment to the level of aggregate physical capacity, and (c) making adjustments to the levels of worker- and production-line-limited capacity. For aggregate capacity planning, the optimal structure is a capacity band whose lower and upper bounds depend on the probability distributions of demand and the cost parameters in a planning horizon. When attempting to plan capacity by simultaneously using overtime and making adjustment to physical capacity, it is optimal to either use overtime or adjust the level of aggregate capacity. The optimal structure for either using overtime or making adjustment to the level of physical capacity is also of the form of a capacity band. The optimal structures for optimal planning of the levels of worker- and production-line-limited capacity consist of two-dimensional capacity regions in which the levels of worker- and line-limited capacity are equal if reducing the levels of capacity yields nonnegative cost saving. This symmetry disappears(cont.) when reducing either level of capacity yields negative cost saving.by Benny S. Budiman.Sc.D
Weight Annotation in Information Extraction
No full textThe framework of document spanners abstracts the task of information extraction from text as a function that maps every document (a string) into a relation over the document's spans (intervals identified by their start and end indices). For instance, the regular spanners are the closure under the Relational Algebra (RA) of the regular expressions with capture variables, and the expressive power of the regular spanners is precisely captured by the class of vset-automata-a restricted class of transducers that mark the endpoints of selected spans. In this work, we embark on the investigation of document spanners that can annotate extractions with auxiliary information such as confidence, support, and confidentiality measures. To this end, we adopt the abstraction of provenance semirings by Green et al., where tuples of a relation are annotated with the elements of a commutative semiring, and where the annotation propagates through the (positive) RA operators via the semiring operators. Hence, the proposed spanner extension, referred to as an annotator, maps every string into an annotated relation over the spans. As a specific instantiation, we explore weighted vset-automata that, similarly to weighted automata and transducers, attach semiring elements to transitions. We investigate key aspects of expressiveness, such as the closure under the positive RA, and key aspects of computational complexity, such as the enumeration of annotated answers and their ranked enumeration in the case of numeric semirings. For a number of these problems, fundamental properties of the underlying semiring, such as positivity, are crucial for establishing tractability.Funding
This work was supported by the German-Israeli Foundation for Scientific Research and
Development (GIF), grant I-1502-407.6/2019. The work of Johannes Doleschal and Wim Martens
was also supported by the Deutsche Forschungsgemeinschaft (DFG), grant MA 4938/4-1. The work
of Benny Kimelfeld and Liat Peterfreund was also supported by the Israel Science Foundation (ISF),
grants 1295/15 and 768/19, and the DFG project 412400621 (DIP program).
Liat Peterfreund: A part of the work was donewhile the author was affiliated with the Technion.
Acknowledgements
We are grateful to Matthias Niewerth for many useful discussions and his help
regarding Theorem 7.1 and Shaull Almagor for many helpful comments regarding weighted automata.
Furthermore, we thank the anonymous reviewers for ICDT 2020 for many helpful remarks
Methods and Applications of Computational Immunology
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Methods and Applications of Computational Immunology
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
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