4 research outputs found
A case series on uterine inversion: diagnostic and surgical considerations
No full textUterine inversion defined as descent of fundus of uterus to or through the cervix, so uterus is turned inside out. It may be puerperal and non-puerperal/gynecological, the latter being extremely rare. This rarity, delayed presentation and atypical presentation contribute to the clinical challenges. We present a case series four cases of uterine inversion including three cases of gynecological inversion and one case of puerperal inversion, managed at a tertiary care hospital in India. Clinical presentation, diagnostic methods, surgical techniques, and outcomes were documented. Non-puerperal cases were associated with submucosal fibroids and presented with mass protrusion, bleeding, and urinary complaints. Diagnosis was confirmed using clinical examination and magnetic resonance imaging (MRI). Surgical management included Huntington’s and Haultain’s techniques followed by hysterectomy. The puerperal case presented with acute hemorrhage postpartum and was managed successfully with Johnson’s maneuver and uterine balloon tamponade. It could be concluded from series that non-puerperal uterine inversion requires individualized surgical management based on underlying pathology. Acute puerperal inversion demands rapid resuscitation and repositioning to reduce maternal morbidity. MRI plays a pivotal role in diagnosis and planning. This series delineates the challenges involved in the diagnosis and operative management of the condition
Ovarian tumors: a case series from a tertiary care center
No full textOvarian cancer is the third most common malignancy among women in India and accounts for approximately 6% of cancer-related deaths, with late-stage presentation being frequent due to vague and nonspecific symptoms. This case series describes twelve patients with ovarian neoplasms diagnosed over six months at a tertiary care center, highlighting the clinical diversity and age-related distribution of these tumors. Most cases were observed in postmenopausal women above 50 years of age, with histopathological types ranging from high-grade serous carcinoma and mucinous carcinoma to mucinous cystadenoma, granulosa cell tumor, dysgerminoma, and metastatic malignant melanoma. Clinical manifestations included abdominal pain, distension, ascites, respiratory difficulty, and in one case, incidental detection during infertility evaluation. Risk factors such as nulliparity, delayed childbearing, and family history were noted. Management strategies varied from surgical excision for benign lesions to cytoreductive surgery with adjuvant chemotherapy for malignant cases. This study underscores the heterogeneity of ovarian tumors and the critical importance of early recognition, accurate histopathological classification, and individualized treatment planning. Despite advances in surgical and chemotherapeutic modalities, prognosis in advanced disease remains poor, emphasizing the need for improved screening strategies, molecular research, and targeted therapies to enhance survival and quality of life
Exploring microbial chain elongation for production of organics and hydrogen in soils
No full textabstract: This research explores microbial chain elongation as a pathway for production of complex organic compounds in soils with implication for the carbon cycle. In chain elongation, simple substrates such as ethanol and short chain carboxylates such as acetate can be converted to longer carbon chain carboxylates under anaerobic conditions through cyclic, reverse β oxidation. This pathway elongates the carboxylate by two carbons. The chain elongation process is overall thermodynamically feasible, and microorganisms gain energy through this process. There have been limited insights into the versatility of chain elongating substrates, understanding the chain elongating microbial community, and its importance in sequestering carbon in the soils.
We used ethanol, methanol, butanol, and hydrogen as electron donors and acetate and propionate as electron acceptors to test the occurrence of microbial chain elongation in four soils with different physicochemical properties and microbial communities. Common chain elongation products were the even numbered chains butyrate, caproate, and butanol, the odd numbered carboxylates valerate and heptanoate, along with molecular hydrogen. At a near neutral pH and mesophilic temperature, we observed a stable and sustained production of longer fatty acids along with hydrogen. Microbial community analysis show phylotypes from families such as Clostridiaceae, Bacillaceae, and Ruminococcaceae in all tested conditions. Through chain elongation, the products formed are less biodegradable. They may undergo transformations and end up as organic carbon, decreasing the greenhouse gas emissions, thus, making this process important to study.Dissertation/ThesisMasters Thesis Chemical Engineering 201
Real world, Non-interventional, Observational Study of Hydroxyzine Hydrochloride in Chronic Pruritus: A Prospective, Non-comparative Study
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