4,979 research outputs found
Mass spectrometry strategies to understand treatment effects and heterogeneity in soft tissue sarcomas
No full textSoft Tissue sarcoma are rare and heterogenous mesenchymal malignancies. Optimal disease management in STS is surgical excision as the primary treatment modality. Despite negative surgical margins, ~50% of patients relapse. Neoadjuvant therapy (NAT) is given prior to surgery for locally advanced and/metastatic disease. However, its use as a standard treatment is contentious due to conflicting results from clinical trials. Additionally, there remains a limited understanding of the underlying biology governing NAT response and resistance. There is an urgent need for improved prognostication to identify patients who would derive substantial benefits from NAT, as well as the identification of predictive biomarkers for NAT response. Proteomic analysis of Sarculator-nomogram risk group, a prognostic tool, rationalized the effectiveness of anthracycline therapy in high-risk patients. This has translated into enhanced overall survival outcomes among high-risk patients, attributed to elevated levels of MCM proteins, integral components of the MCM complex responsible for initiating DNA replication prior to the G1 phase of the cell cycle. Notably, this study marks the first integration of proteomics data with the Sarculator nomogram to develop advanced prognostic tools. Furthermore, both transcriptomics and proteomics data identified the presence of two distinct molecular subtypes within synovial sarcoma (SS), each characterized by unique biological features. The analysis has also unveiled pathways associated with NAT response, including epithelial-mesenchymal transition, MYC targets, and heightened immune signalling. Moreover, through comparative analysis of transcriptomic and proteomic datasets, distinct prognostic biomarkers associated with each omics platform have been identified, emphasizing the valuable and distinct information contained within each dataset. By integrating these two datasets, a panel of 58 biomarkers (comprising 45 proteins and 13 genes) have been identified, effectively segregating NAT-treated SS samples from treatment-naïve samples. In summary, this project offers valuable insights into the biology underlying NAT and demonstrates the potential of integrating proteomic signatures with nomograms to create advanced prognostic tools for the future
RDLS-SS-DWT v. 0.9
No full textThis fileset contains the implementation of RDLS-DWT and SS-DWT in JPEG 2000 (RDLS-SS-DWT v. 0.9), which was used in a research described in: R. Starosolski, “Application of reversible denoising and lifting steps to DWT in lossless JPEG 2000 for improved bitrates,” Signal Processing: Image Communication, Vol. 39, Part A, pp. 249-63, DOI: 10.1016/j.image.2015.09.013, 2015 and R. Starosolski, “Skipping selected steps of DWT computation in lossless JPEG 2000 for improved bitrates,” submitted. This software is intended for research purposes only; it is provided "as is"; author makes no warranty of any kind, either express or implied, with respect to this software. <br
SS Northland Echo
No full textPhotograph - A view of the steamboat, SS Northland Echo on the Athabasca River. Athabasca, Albert
SS Athabasca River - 02
No full textPhotograph - A view of the SS Athabasca River paddle steamer on the river, Athabasca, Albert
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
SS Northland Sun at Mirror Landing, AB
No full textPhotograph - The paddle-wheeler, SS Northland Sun, docked at shore in Mirror Landing, Albert
SS Northland Light at Sawridge, AB
No full textPhotograph - Paddle-wheeler, SS Northland Light, docked at the shore. Sawridge, A
That's 'é' not 'þ' '?' or '☐': a user-driven context-aware approach to erroneous metadata in digital libraries
No full textIn this paper we present a novel system for user-driven integration of name variants when interacting with web-based information systems. The growth and diversity of online information means that many users experience disambiguation and collocation errors in their information searching. We approach these issues via a client-side JavaScript browser extension that can reorganise web content and also integrate remote data sources. The system is illustrated through three worked examples using existing digital libraries
SS-Sonderkommando Bełżec. Portret zbiorowy
No full textSS-SONDERKOMMANDO BELZEC. A COLLECTIVE PORTRAIT The subject-matter of this paper’s analysis revolves around the members of SS and German police who, during the 1941–1943 period, belonged to SS-Sonderkommando Belzec or Dienstelle Belzec der Waffen SS — as the extermination camp in Belzec was officially known. It was the first center of “Action Reinhardt,” implemented in the General Government and in Białystok District, in which around four hundred fifty thousand Jews were murdered by the Nazis. In writing of this article its author used documents from German and Polish archives, scholarly and popular literature on the subject and memories. These sources served as a foundation on the basis of which the attempt to create a collective portrait of perpetrators was undertaken. The author of the article, as it is accepted in historiography, based his conclusions on thirty seven members of SS-Sonderkommando Belzec who were at least temporarily employed in the camp — during its building, its operation, the extermination or the erasing of traces. The article analyzes the age of the members of Belzec camp’s personnel, their nationality and birthplace, education, participation in National Socialist organizations, engagement in “T4” action and — in the widest possible terms — participation in the Holocaust. The article describes the process of selection to the SS crew, the principles governing the assignation of functions and duties in the camp, the exchange of members between different centers of “Action Reinhardt,” their future fate and the question of their postwar legal punishment. More attention is paid to two commandants, i.e. Christian Wirth and Gottlieb Hering. The article indicates the similarities and differences between them, their impact on the camp’s operation and their influence over other members of SS-Sonderkommando Belzec.SS-SONDERKOMMANDO BELZEC. A COLLECTIVE PORTRAIT The subject-matter of this paper’s analysis revolves around the members of SS and German police who, during the 1941–1943 period, belonged to SS-Sonderkommando Belzec or Dienstelle Belzec der Waffen SS — as the extermination camp in Belzec was officially known. It was the first center of “Action Reinhardt,” implemented in the General Government and in Białystok District, in which around four hundred fifty thousand Jews were murdered by the Nazis. In writing of this article its author used documents from German and Polish archives, scholarly and popular literature on the subject and memories. These sources served as a foundation on the basis of which the attempt to create a collective portrait of perpetrators was undertaken. The author of the article, as it is accepted in historiography, based his conclusions on thirty seven members of SS-Sonderkommando Belzec who were at least temporarily employed in the camp — during its building, its operation, the extermination or the erasing of traces. The article analyzes the age of the members of Belzec camp’s personnel, their nationality and birthplace, education, participation in National Socialist organizations, engagement in “T4” action and — in the widest possible terms — participation in the Holocaust. The article describes the process of selection to the SS crew, the principles governing the assignation of functions and duties in the camp, the exchange of members between different centers of “Action Reinhardt,” their future fate and the question of their postwar legal punishment. More attention is paid to two commandants, i.e. Christian Wirth and Gottlieb Hering. The article indicates the similarities and differences between them, their impact on the camp’s operation and their influence over other members of SS-Sonderkommando Belzec
German SS Feldpost Correspondence from the SS Freiwilligen Legion Niederlande
No full textEnvelope address written in blue ink, “SS Feldpost” written in top right corner, stamped with round “FELDPOST” stamp dated “06.10.41” Letter written in blue ink, dated “5.10.1941” in upper right corner.
Information Provided by Michael D. Bulmash: The author of this letter was a member of the collaborationist Dutch volunteer SS-legion formed soon after the commencement of Operation Barbarossa in 1941, to assist Germans in their war against Bolshevism and Communism. Himmler and Hitler could make much of the idea that Germanic Europe was supporting their cause, since a number of Danes, Dutch, Finns, and Swedes had volunteered to serve in the Waffen-SS.https://digital.kenyon.edu/bulmash/2612/thumbnail.jp
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