1,720,958 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Décryptage multi-échelle des effets du BMP2 sur la migration collective et le remodelage de l'épithélium mammaire : un rôle clef de l’intégrine β1?
No full textDuring the neoplastic transformation, a solid-to-liquid transition can overcome the motility arrest of healthy, confluent epithelial cells, and promote tissue fluidization through large-scale collective cell migration. How cells control such transitions needs to be explored. Whether and how integrins, as cell-matrix receptors, participate in intercellular communications to support collective cell migration remains unexplored. Previous works of our team have shown the role of BMP2 as member of TGFβ family in the induction of the migration of isolated cells through not only the cooperation between integrins and BMP2 receptors but also the segregation of ALK3 and not BMPR2 in integrin-mediated adhesion sites. Knowing the involvement of BMP2 in morphogenesis and cancer, we sought to test whether and how BMP2 may influence the coordination of movement in breast epithelium. As contrary to TGFβ, BMP2 enhances cell coordination and sustains E-cadherin at cell-cell contact to support collective migration. This collective network migration and cell cluster migration in 2D induced by BMP2 is associated with a partial Epithelio-Mesenchymal Transition (EMT) of MCF10A cells. MCF10A cells adopt an elongated shape through junctional plasticity. BMP2-treated 3D breast acini undergo disorganisation of actin cytoskeleton and perturbation of the apico-basal polarity. Solid-liquid and acini-spheroid transitions are correlated with a perturbed distribution of β1 integrin at cell-cell and cell-ECM contacts. The fluidization of MCF-10A monolayer required β1 integrin to control collective migration. Mechanistically, our results suggest that β1 integrin might contribute to epithelial tissue cohesion through the building of mechanosensitive structures to safeguard breast epithelium integrity.Au cours de la transformation néoplasique, une transition solide-liquide peut déclencher la motilité des cellules épithéliales et favoriser la fluidification des tissus par une migration collective des cellules à grande échelle. La manière dont les cellules contrôlent ces transitions doit être étudiée. La question de savoir si et comment les intégrines, en tant que récepteurs de la matrice cellulaire, participent aux communications intercellulaires pour soutenir la migration collective des cellules reste inexplorée. Des travaux antérieurs de notre équipe ont montré le rôle de BMP2, membre de la famille TGFβ, dans l'induction de la migration de cellules isolées par le biais non seulement de la coopération entre les intégrines et les récepteurs de BMP2, mais aussi de la ségrégation d'ALK3 et non de BMPR2 dans les sites d'adhésion médiés par les intégrines. Connaissant l'implication de BMP2 dans la morphogenèse et le cancer, nous avons cherché à vérifier si et comment BMP2 pouvait influencer la coordination des mouvements dans l'épithélium mammaire. Contrairement au TGFβ, la BMP2 induit la coordination cellulaire et maintient la E-cadhérine au niveau du contact cellule-cellule pour favoriser la migration collective. Cette migration collective caractérisée par une coordination au sein de groupes de cellules est associée à une transition épithélio-mésenchymateuse partielle des cellules MCF10A. Les cellules MCF10A adoptent une forme allongée ainsi qu’une plasticité jonctionnelle. Les acini mammaires 3D traités au BMP2 subissent une désorganisation du cytosquelette d'actine et une perturbation de la polarité apico-basale. Les transitions solide-liquide et acini-sphéroïde sont corrélées à une distribution perturbée de l'intégrine β1 aux contacts cellule-cellule et cellule-matrice. La fluidité de l’épithélium mammaire nécessite l'intégrine β1 pour contrôler la migration collective. D'un point de vue mécanique, nos résultats suggèrent que l'intégrine β1 pourrait contribuer à la cohésion du tissu par la construction de structures mécanosensibles pour sauvegarder l'intégrité de l'épithélium mammaire
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Multi-scale Analysis of BMP2 Effects on Collective Migration and Remodeling of Mammary Epithelium : A Key Role of β1 Integrin?
No full textAu cours de la transformation néoplasique, une transition solide-liquide peut déclencher la motilité des cellules épithéliales et favoriser la fluidification des tissus par une migration collective des cellules à grande échelle. La manière dont les cellules contrôlent ces transitions doit être étudiée. La question de savoir si et comment les intégrines, en tant que récepteurs de la matrice cellulaire, participent aux communications intercellulaires pour soutenir la migration collective des cellules reste inexplorée. Des travaux antérieurs de notre équipe ont montré le rôle de BMP2, membre de la famille TGFβ, dans l'induction de la migration de cellules isolées par le biais non seulement de la coopération entre les intégrines et les récepteurs de BMP2, mais aussi de la ségrégation d'ALK3 et non de BMPR2 dans les sites d'adhésion médiés par les intégrines. Connaissant l'implication de BMP2 dans la morphogenèse et le cancer, nous avons cherché à vérifier si et comment BMP2 pouvait influencer la coordination des mouvements dans l'épithélium mammaire. Contrairement au TGFβ, la BMP2 induit la coordination cellulaire et maintient la E-cadhérine au niveau du contact cellule-cellule pour favoriser la migration collective. Cette migration collective caractérisée par une coordination au sein de groupes de cellules est associée à une transition épithélio-mésenchymateuse partielle des cellules MCF10A. Les cellules MCF10A adoptent une forme allongée ainsi qu’une plasticité jonctionnelle. Les acini mammaires 3D traités au BMP2 subissent une désorganisation du cytosquelette d'actine et une perturbation de la polarité apico-basale. Les transitions solide-liquide et acini-sphéroïde sont corrélées à une distribution perturbée de l'intégrine β1 aux contacts cellule-cellule et cellule-matrice. La fluidité de l’épithélium mammaire nécessite l'intégrine β1 pour contrôler la migration collective. D'un point de vue mécanique, nos résultats suggèrent que l'intégrine β1 pourrait contribuer à la cohésion du tissu par la construction de structures mécanosensibles pour sauvegarder l'intégrité de l'épithélium mammaire.During the neoplastic transformation, a solid-to-liquid transition can overcome the motility arrest of healthy, confluent epithelial cells, and promote tissue fluidization through large-scale collective cell migration. How cells control such transitions needs to be explored. Whether and how integrins, as cell-matrix receptors, participate in intercellular communications to support collective cell migration remains unexplored. Previous works of our team have shown the role of BMP2 as member of TGFβ family in the induction of the migration of isolated cells through not only the cooperation between integrins and BMP2 receptors but also the segregation of ALK3 and not BMPR2 in integrin-mediated adhesion sites. Knowing the involvement of BMP2 in morphogenesis and cancer, we sought to test whether and how BMP2 may influence the coordination of movement in breast epithelium. As contrary to TGFβ, BMP2 enhances cell coordination and sustains E-cadherin at cell-cell contact to support collective migration. This collective network migration and cell cluster migration in 2D induced by BMP2 is associated with a partial Epithelio-Mesenchymal Transition (EMT) of MCF10A cells. MCF10A cells adopt an elongated shape through junctional plasticity. BMP2-treated 3D breast acini undergo disorganisation of actin cytoskeleton and perturbation of the apico-basal polarity. Solid-liquid and acini-spheroid transitions are correlated with a perturbed distribution of β1 integrin at cell-cell and cell-ECM contacts. The fluidization of MCF-10A monolayer required β1 integrin to control collective migration. Mechanistically, our results suggest that β1 integrin might contribute to epithelial tissue cohesion through the building of mechanosensitive structures to safeguard breast epithelium integrity
Décryptage multi-échelle des effets du BMP2 sur la migration collective et le remodelage de l'épithélium mammaire : un rôle clef de l’intégrine β1?
No full textDuring the neoplastic transformation, a solid-to-liquid transition can overcome the motility arrest of healthy, confluent epithelial cells, and promote tissue fluidization through large-scale collective cell migration. How cells control such transitions needs to be explored. Whether and how integrins, as cell-matrix receptors, participate in intercellular communications to support collective cell migration remains unexplored. Previous works of our team have shown the role of BMP2 as member of TGFβ family in the induction of the migration of isolated cells through not only the cooperation between integrins and BMP2 receptors but also the segregation of ALK3 and not BMPR2 in integrin-mediated adhesion sites. Knowing the involvement of BMP2 in morphogenesis and cancer, we sought to test whether and how BMP2 may influence the coordination of movement in breast epithelium. As contrary to TGFβ, BMP2 enhances cell coordination and sustains E-cadherin at cell-cell contact to support collective migration. This collective network migration and cell cluster migration in 2D induced by BMP2 is associated with a partial Epithelio-Mesenchymal Transition (EMT) of MCF10A cells. MCF10A cells adopt an elongated shape through junctional plasticity. BMP2-treated 3D breast acini undergo disorganisation of actin cytoskeleton and perturbation of the apico-basal polarity. Solid-liquid and acini-spheroid transitions are correlated with a perturbed distribution of β1 integrin at cell-cell and cell-ECM contacts. The fluidization of MCF-10A monolayer required β1 integrin to control collective migration. Mechanistically, our results suggest that β1 integrin might contribute to epithelial tissue cohesion through the building of mechanosensitive structures to safeguard breast epithelium integrity.Au cours de la transformation néoplasique, une transition solide-liquide peut déclencher la motilité des cellules épithéliales et favoriser la fluidification des tissus par une migration collective des cellules à grande échelle. La manière dont les cellules contrôlent ces transitions doit être étudiée. La question de savoir si et comment les intégrines, en tant que récepteurs de la matrice cellulaire, participent aux communications intercellulaires pour soutenir la migration collective des cellules reste inexplorée. Des travaux antérieurs de notre équipe ont montré le rôle de BMP2, membre de la famille TGFβ, dans l'induction de la migration de cellules isolées par le biais non seulement de la coopération entre les intégrines et les récepteurs de BMP2, mais aussi de la ségrégation d'ALK3 et non de BMPR2 dans les sites d'adhésion médiés par les intégrines. Connaissant l'implication de BMP2 dans la morphogenèse et le cancer, nous avons cherché à vérifier si et comment BMP2 pouvait influencer la coordination des mouvements dans l'épithélium mammaire. Contrairement au TGFβ, la BMP2 induit la coordination cellulaire et maintient la E-cadhérine au niveau du contact cellule-cellule pour favoriser la migration collective. Cette migration collective caractérisée par une coordination au sein de groupes de cellules est associée à une transition épithélio-mésenchymateuse partielle des cellules MCF10A. Les cellules MCF10A adoptent une forme allongée ainsi qu’une plasticité jonctionnelle. Les acini mammaires 3D traités au BMP2 subissent une désorganisation du cytosquelette d'actine et une perturbation de la polarité apico-basale. Les transitions solide-liquide et acini-sphéroïde sont corrélées à une distribution perturbée de l'intégrine β1 aux contacts cellule-cellule et cellule-matrice. La fluidité de l’épithélium mammaire nécessite l'intégrine β1 pour contrôler la migration collective. D'un point de vue mécanique, nos résultats suggèrent que l'intégrine β1 pourrait contribuer à la cohésion du tissu par la construction de structures mécanosensibles pour sauvegarder l'intégrité de l'épithélium mammaire
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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