73 research outputs found
Effects of eccentric exercise induced delayed onset muscle soreness on some endoplasmic reticulum stress parameters in athletes
No full textEndoplazmik retikulum (ER)'da katlanmamış ya da hatalı katlanmış proteinlerin birikmesi ER stres olarak tanımlanmaktadır ve tekrarlı eksentrik egzersizler ile oluşturulan kas hasarının, çalışan iskelet kaslarında ER strese neden olabileceği gösterilmiştir. Kas hasarı ve oluşan gecikmiş kas yorgunluğunun ise sporcu performansını olumsuz etkilediği bilinmektedir. Bu çalışmada genç sporcularda eksentrik egzersiz ile oluşturulan gecikmiş kas yorgunluğunun ER stres parametreleri üzerine etkisi incelenmiştir. Çalışmaya düzenli antrenman yapan 18 genç erkek futbolcu katıldı. Katılımcılara izokinetik dinamometre kullanılarak eksentrik kasılmaları içeren bir kas yorgunluğu protokolü uygulandı. Protokolden önce, hemen sonra, 24, 48 ve 72 saat sonra olmak üzere toplam 5 kez alınan kan örneklerinde ER stres belirteçlerinden apelin, interlökin 6 (IL6), pentraksin3 (PTX3) ile kas hasarı belirteçlerinden kreatin kinaz (CK) ve laktat dehidrogenaz (LDH) enzim düzeyleri bakıldı. Ayrıca kan alımının ardından katılımcılara aynı sıra ile maksimal kuvvet testi uygulandı ve görsel analog skalası (GAS) kullanılarak yorgunluk algısı düzeyi değerlendirildi. İstatistiksel analizler için tekrarlanan ölçümlerinin karşılaştırılmasında Friedman F testi, farkın hangi ölçümden kaynaklandığının tespiti için Wilcoxon işaretli sıra testi ile kuvvet verileri için tekrarlayan ölçümlerde varyans analizi, farkın hangi gruptan kaynaklandığını analiz etmek için ise Bonferroni post hoc prosedürü uygulandı. Veriler arasındaki anlamlı ilişkiyi saptamak için Spearman Korelasyon testi uygulandı. İstatistiksel anlamlılık için p ≤ 0.05 değeri kabul edildi. Egzersiz öncesi ve hemen sonrasındaki ölçüm sonuçları arasında IL6, CK, LDH düzeyleri, kuvvet testi ve GAS'da (p<0.05); tekrarlayan ölçümleri arasında PTX3 dışındaki tüm parametrelerde anlamlı farklılık bulundu. 24. saatteki ölçümlerde PTX3, IL6, CK; 48. saatte LDH düzeylerinin en yüksek değerine ulaştığı görüldü. Kas hasarı egzersiz protokolü sonrasında apelin, IL6 ve PTX3 düzeylerinde gözlenen artışlar ER stres oluşumunu; CK, LDH, GAS'taki artışlar ile kuvvet azalması ise GKY oluşumunu destekler görünmektedir.The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) is defined as ER stress and it has been shown that muscle damage caused by repeated eccentric exercises have provoked ER stress in the skeletal muscles. Muscle damage and delayed onset muscle soreness (DOMS) are known to negatively affect athlete performance. The aim of the study was to investigate the effect of eccentric exercise induced DOMS on ER stress parameters in young athletes. Eighteen young male football players participated in the study voluntarily. A muscle damage protocol with eccentric contractions with an isokinetic dynamometer was used for participants. Apelin, interleukin 6 (IL6), Pentraxin 3 (PTX3) and as muscle damage markers creatine kinase (CK) and lactate dehydrogenase (LDH) enzyme levels were assessed in totally 5 times from blood samples as baseline, immediately after, 24, 48 and 72 hours after the exercise protocol. In addition, maximal strength test and rate of perceived exertion using visual analogue scale (GAS) were applied to participants in the same order after blood collection. The Friedman F test was used to compare repeated measures for statistical analysis, Wilcoxon signed rank test to determine which measure the statistical difference originated from, analysis of variance in repeated measures for force data, and the Bonferroni post hoc procedure was used to analyze which group the difference originated from for only maximal strength data. Spearman correlation test was used to determine the significant relationship. Statistical significance was set at the 0.05 level of confidence. There were significant differences between baseline and first post-test of exercise protocol for IL6, CK, LDH levels and strength test, and GAS; and between repeated measures for all parameters except PTX3 (p<0.05). PTX3, IL6, CK levels reached peak at 24 h after exercise, while LDH level reached it's peak at 48h. Increases in apelin, IL6 and PTX3 levels following muscle damage protocol may have resulted in ER stress formation; increases in CK, LDH, GAS and decrease in strength levels seem to provide existence of DOMS
Resonance, Repetition, and Memetic Intervention: Analyzing 'I am sitting in a room' with Alvin Lucier, Brad Troemel, and Amalia Ulman in the Social Media Landscape
No full textThis dissertation explores the intersection of social media, memes, and artistic practice. The author argues that social media has become a tool for the commodification of identity, and that this process has led to a profound sense of alienation and distrust. The author examines the work of three artists, Alvin Lucier, Brad Troemel and Amalia Ulman, the latter of which have used social media to challenge the dominant narratives of identity and activism. The author establishes a metaphorical model based on Alvin Lucier’s ‘I am sitting in a room’ through resonance and repetition which is then extended to understand the complexity of social media echo chambers.</p
Resonance, Repetition, and Memetic Intervention: Analyzing 'I am sitting in a room' with Alvin Lucier, Brad Troemel, and Amalia Ulman in the Social Media Landscape
No full textThis dissertation explores the intersection of social media, memes, and artistic practice. The author argues that social media has become a tool for the commodification of identity, and that this process has led to a profound sense of alienation and distrust. The author examines the work of three artists, Alvin Lucier, Brad Troemel and Amalia Ulman, the latter of which have used social media to challenge the dominant narratives of identity and activism. The author establishes a metaphorical model based on Alvin Lucier’s ‘I am sitting in a room’ through resonance and repetition which is then extended to understand the complexity of social media echo chambers.</p
THE EFFECTS OF THE RESISTANCE TRAINING ON SERUM CORTISOL, IL-6, IL-8, AND TNF- alpha
No full textObjective: The purpose of this study is to investigate effects of resistance training on IL-6, IL-8, TNF-alpha, blood hematocrit and cortisol levels. Materials and Methods: Thirteen players from Manisa Celal Bayar University soccer team and 14 sedentary male students were used as the study subjects. The subjects, whose average age was 18-24 years old, were healthy and free of any cardiovascular diseases. Anthropometrics measurements and blood samples were obtained from all the subjects. Blood samples were obtained basal sample (before the exercise), immediately after the training program (post-exercise), and 2 hours after the training program (2h post-exercise). All subjects participated in the training program in which intensity prescribed individually in 10 different exercises; seated leg press, knee extension, knee flexion, chest press, chest flys, lat pull down, shoulder press, triceps extension, biceps curl and sit-ups. The exercise protocol was 8-10-12 repetitions of each exercise at 70 to 80 % of one-repetition maximum in accordance with the pyramid training system and three sets for each station. The volume of resistance training was 50-60 minutes. Results: Post exercise IL-6 (p=0.05) and IL-8 (p=0.04) concentration of athletes were statistically lower compared to that of sedentary group. Two hours after the exercise, the TNF-alpha values of the sedentary individuals were also statistically higher than those of the trained individuals. Furthermore, serum cortisol concentrations were found to be decreased in both study groups in post exercise and 2h post exercise samples compared to basal values (p<0.05). Post exercise IL-8 (p=0.04) and TNF-alpha (p=0.04) values of sedentary group increased significantly compared to values at 2h post exercise. There was no statistically significant change in IL 6 values of the trained and sedentary subjects immediately after the exercise. Conclusion: IL-6, IL-8, and TNF-alpha responses to resistance training vary depending on the recruitment of different muscle fiber types by the trained individuals during the resistance training and the recovery of glycogen storage, which is found to be different from that of sedentary individuals. The decrease in the serum IL-6 and IL-8 concentrations at post exercise and 2h post-exercise samples in the training group when compared to the sedantary group revealed us that, training lowers the proinflammatory marker IL-6 and IL-8 which reflects a positive effect of the training on the overall body inflammation status
The incidence and risk factors of neural tube defects in Izmir, Turkey: a nested case-control study
No full textThe aim of this study was to determine the incidence of neural tube defects (NTDs) in Izmir, Turkey, and to evaluate risk factors that may be associated with NTD-affected pregnancies. A nested case-control study was carried out in all hospitals in Izmir. Controls were matched with cases on an individual basis according to the newborn's age and hospital in which they were born. There were 56 newborns with NTD out of 36,331 deliveries in Izmir hospitals in 2000. The incidence of NTD was 1.5 per 1000 births. Forty-four cases and 88 controls were analyzed for risk factors. According to chi-square analysis, maternal education, paternal education, maternal nutritional status, maternal drug usage, and presence of maternal chronic diseases and acute infections during pregnancy were found significantly different between case and control groups
Analysis of cloud based monitoring tools
No full textThe goal of this research is to find out optimum cloud monitoring solution and proposing to technical implementation for a company. Thesis focuses on a specific topic in a cloud monitoring area and goes into more details.
Firstly, author makes critical literature review of the topic in general cloud computing, service and deployment models, cloud computing monitoring, taxonomy of monitoring areas. Secondly, analysis companys ambitions, visions, goals, short and long term strategic plans in general by making brief case study.
Thirdly, author starts analysis to find out best cloud monitoring solutions to monitor a large enterprise applications by applying empirical methods.
Fourthly, author designs and technically implements new solution as a proposal.
Author, include in his analyses new log-file based monitoring tool called Splunk and proposes as a best monitoring tool in this companys on-premise and hybrid cloud environments. At the end author proposes to implement Splunk by making component design of this tool.
This research is targeted also to:
Public, Private or Hybrid cloud solution integrated enterprises.
Enterprises that suppose to migrate data into cloud.
Enterprises that use very large scalable embedded systems
Careers and Research Performance of PhD Program Graduates of Health Sciences in Turkey
No full textIn this review, we aimed to evaluate PhD graduates of the period between 1985-2010 and analyze the status, motivation and positive and negative factors influencing research motivation of graduates in eight disciplines from three graduate schools of Health Sciences in Turkey and to compare with the present status in the world. Some information obtained by web-based survey is the following: The most of graduates (83%) have academic positions in basic sciences departments in the faculty of medicine in universities. 94.2 % of graduates recognized the importance of personal motivation, while 54% of them thought that finding the appropriate research environment was important for research. For 52%, the biggest hindrance to medical research was lack of funding and for 39%, lack of technic personnel for research. The studies in the literature related to PhD graduates pointed out to the following facts: The number of PhD graduates is increasing gradually and the graduates' career choices have changed from academic to non-academic positions, especially in the industry. This is not parallel to our pilot study findings. About the teaching perspective treated in the relevant literature, the concept of "one should be a good researcher, as well as a good teacher" is dominant. PhD graduates in our pilot study mentioned that they had responsibilities in the education activities during their PhD education. We think that these responsibilities are useful for their future academic career. In conclusion, the majority (83%) of graduates from Graduate Schools of Health Sciences in Turkey are enrolled into academic researcher positions in universities. They keep producing funded research work as a first author and publish despite some problems
Electronic medical report and e-health
No full textThis bachelor thesis is devoted to the topic of electronic health or eHealth. The main goal of the thesis is to identify and provide an overview of eHealth, electronic health in the Czech Republic along with Czech and European eHealth projects. Based on the gained findings from the practical part, author will provide a system solution.
The theoretical part focuses on the definition of eHealth, based on the literature. This mainly includes eHealth in the Czech Republic, Data standards and development of the eHealth.
The practical part is focused on the comparison of eHealth and eHealth related tools. From provided interview with eHealth systems specialist, two system solutions created by the author of the thesis are proposed. Solutions are later analyzed by the SWOT analysis.
In the last part of the thesis final evaluation of the topic and results from the practical part is given
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