101,970 research outputs found
Mesenchymal Stromal cells from Wharton's jelly (MSCs): coupling their hidden differentiative program to their frank immunomodulatory phenotype.
No full textNo abstrac
Wharton's jelly mesenchymal stem cells and immune modulation: regenerative medicine meets tissue repair
No full textBibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Beyond motor neurons: new insights on amyotrophic lateral sclerosis neurodegeneration provided by advanced MRI tecnique
No full textAim
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the progressive degeneration of upper and lower motor neurons, but does not spare extra-motor areas, causing cognitive and behavioural syndromes.
To better investigate structural and functional abnormalities in ALS, we used resting-state fMRI data combined to VBM analysis and a quantitative DTI approach, by a TBSS analysis, in a population of behaviour impaired ALS patients.
Methods
We investigated 20 ALS patients (10 women and 10 men) ranging from 34 to 80 years (mean age 60.7 ± 11.1) of age, fulfilling the diagnostic criteria for probable or definite ALS, according to the revised El Escorial criteria of the World Federation of Neurology.
The control group comprised 20 healthy controls (10 men, 10 women) aged from 46 to 78 years (mean age 62.1 + 8.5 years) with no history of neurological or psychiatric diseases and without any abnormalities detected on conventional MRI T1 and T2 weighted images.
Magnetic resonance images were acquired on a 3-T GE Medical System scanner equipped with an 8-channel parallel head coil.
Results
The sensori-motor network (SMN) showed significant disease effects, with signal suppression in patients in the primary and the supplementary motor cortices. The same was visible frontally in the right fronto-parietal network, possibly reflecting the patients' frontal dysfunction. Compared with controls, ALS patients had significant clusters of reduced GM density in the left premotor and right fronto-parietal cortex. DTI analysis showed reduced FA values in the body of corpus callosum (CC) and bilaterally in WM tracts from the central CC to primary motor and premotor cortices, also including, with slight prevalence in the left hemisphere, corona radiata, anterior cingulate, superior longitudinal, inferior longitudinal, inferior occipito-frontal and uncinate fasciculi. The DTI pattern of predominantly frontal WM injury clearly reflects the frontal executive dysfunction that characterizes our ALS patients, and is in agreement with the growing body of evidence that degeneration of the frontotemporal lobar type may occur in ALS with a variable range of behavioral and cognitive impairments among patients. In patients a significant decrease of FA compared to controls mainly in the midbody of the CC, where for reduced FA vs increased UMN score a strong significant correlation was also seen. Additionally, for reduced FA vs lower ALS functional rating scale revised (ALSFRS-R), index of patients' disability, a striking trend of correlation was found both in in the WM underneath the left premotor cortex, especially the left paracentral lobule, including also anterior cingulate and superior longitudinal fasciculus. We confirmed the effect of ALS on the SMN network and investigated the possible extramotor involvement in ALS. The correlations between reduction of FA in the body of CC with the UMN score indicate that the WM degeneration in the CC is strictly related to the ALS pyramidal impairment, whilst the correlation between FA and ALSFRS-R in the associative tracts underneath the left premotor cortex might reflect the progressive spread of the disease from motor towards extra-motor areas
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Flessibilità del lavoro e innovazione di prodotto: le tendenze divergenti nei paesi dell’UE
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