131,289 research outputs found
Halloysite nanotubes as a carrier of cornelian cherry (Cornus mas L.) bioactives
No full textCornelian cherry fruit extract rich in anthocyanins and iridoids was encapsulated in the halloysite nanotubes in order to obtain a stable nanoscale system for better delivery and prolonged release of bioactive constituents. The cyclic vacuum technique was used for halloysite nanotubes-cornelian cherry composite preparation and the loading of 8.5 wt% was achieved. Pure cornelian cherry extract exhibited antiproliferative effect on HT-29, MCF7, and MRC-5 cells, pristine halloysite nanotubes affected the growth of MCF7 cells, while halloysite nanotubes-cornelian cherry composites demonstrated proliferative activity in all tested cells. The sustained release of anthocyanins was achieved by this encapsulation strategy. Additional implementation of halloysite nanotubes-cornelian cherry into yogurt prolonged the release of iridoid molecules. Obtained results indicate that halloysite nanoclay is a suitable nanocarrier for cornelian cherry constituents that can be utilized in food and pharmaceutical industries
A one step enhanced extraction and encapsulation system of cornelian cherry (Cornus mas L.) polyphenols and iridoids with β-cyclodextrin
No full textThe objective of this study was simultaneous extraction and encapsulation of cornelian cherry active principles. As an encapsulating agent, β-cyclodextrin (β-CD) was used to enhance the ultrasound-assisted extraction of cornelian cherry polyphenols and iridoids. Lyophilized cornelian cherry fruit was extracted by four different solvents: pure water, 50% aqueous ethanol (conventional system), 1.5% β-CD water solution and 1.5% β-CD aqueous ethanol solution. The highest enhancement of the extraction efficiency was observed for flavonoids and anthocyanins, especially for cyaniding 3-galactoside and pelargonidin 3-galactoside. Water-ethanolic extract was used to form inclusion complexes between β-CD and cornelian cherry bioactives in the solid form. The encapsulation efficiency of cornelian cherry polyphenols in β-CD was 65.62%. Due to the polyphenol encapsulation within β-CD, the extract showed better solubility in water, higher antioxidant power (for 40.61%), and the release of anthocyanins from the dried powder was prolonged for 50% in the first 2 h making it suitable for diverse applications in food and pharmaceutical industries
Anthocyanins and phenolic acids from Prunus spinosa L. encapsulation in halloysite and maltodextrin based carriers
No full textHalloysite, as an inorganic nanoclay material, maltodextrin, as a carbohydrate polymer, and the composite made of them were tested as encapsulating agents for blackthorn (Prunus spinosa L.) extract rich in phenolic acids and anthocyanins. For the halloysite nanotubes loading cyclic vacuum technique was applied, and maltodextrin encapsulates were prepared by freeze-drying process. Thermogravimetric analysis confirmed that blackthorn extract was encapsulated with halloysite, maltodextrin, and maltodextrin-halloysite composite. The cytotoxic effect of the encapsulates was tested in tumor (MCF7 and HT-29) and non-tumor (MRC-5) cells. The release of four major phenolic compounds: 3-O-caffeoylquinic acid (neochlorogenic acid) and, cyanidin 3-O-glucoside, cyanidin 3-O-rutinoside, and peonidin 3-O-rutinoside was tested. Addition of extract and encapsulates in yoghurt prolonged the release of blackthorn bioactives. These results indicate that blackthorn extract and its halloysite and maltodextrin encapsulates have potential in the production of functional foods, food supplements, and pharmaceuticals
Composition, texture, sensorial quality, and biological activity after in vitro digestion of durum wheat pasta enriched with carrot waste extract encapsulates
No full textAim of this research was to evaluate durum-wheat pasta enriched with encapsulated carrot waste extracts in oil, obtained by freeze drying (FDE) or spray drying techniques (SDE). Five pastas (control, enriched with 10% FDE, or 10% SDE, or 20% FDE, or 20% SDE) were evaluated for furosine, carotenoids, tocols, colour, in vitro bioactivities, cooking performance, texture and sensory quality. The encapsulates added to the enriched pastas α-carotene (0.58–1.24 mg/kg), β-carotene (1.43–3.29 mg/kg), cis-β-carotene (0.51–1.11 mg/kg) and total tocols (10.9–33.6 mg/kg). The carotenes were stable and the tocols diminished (-13%) during pasta manufacturing; both decreased (2–18% and 4–15%, respectively) during cooking, but they were still more abundant in the enriched pastas. Antioxidant, anti-hyperglycaemic, anti-inflammatory and anti-proliferative activities after in vitro digestion of cooked pastas improved, while sensory acceptability of control and 10% enriched pastas were similar. The encapsulates addition significantly improved the nutritional and technological qualities of durum-wheat pasta
FIGURE 3 in Donysia avia (Primulaceae), a new species from Zagros Mountains, Iran
No full textFIGURE 3. Distribution map of Dionysia avia, D. bachtiarica and D. lamingtonii.Published as part of Mehregan, Iraj, Younesi, Simin & Lidén, Magnus, 2021, Donysia avia (Primulaceae), a new species from Zagros Mountains, Iran, pp. 296-300 in Phytotaxa 511 (3) on page 299, DOI: 10.11646/phytotaxa.511.3.9, http://zenodo.org/record/542678
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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