1,720,969 research outputs found
Fattori predittivi di colite ulcerosa severa in una coorte italiana
No full textABSTRACT BACKGROUND La colite acuta severa (ASC) presenta dei criteri diagnostici ben definiti (4,111) che permettono di seguirne l’evoluzione ed aiutano nella gestione dei pazienti. Ancora nel 2019 rimane una condizione potenzialmente mortale: in uno studio retrospettivo inglese, la mortalità complessiva di 2981 pazienti ricoverati con colite severa era dell’ 1.2%, dell’ 1.9% in pazienti di età compresa tra 50-59 anni, 3.5% tra 60-69 anni e oltre il 10% in pazienti con età superiore agli 80 anni. Inoltre , 93/750 (12%) pazienti con colite ulcerosa (UC) diagnosticati e seguiti nel follow-up presso l’università di Oxford, hanno fatto ricorso alla colectomia proprio per colite severa non responsiva a trattamenti medici, facendo di questa condizione la principale causa di colectomia (20). SCOPO DELLO STUDIO Lo scopo del presente studio è stato quello di validare un indice prognostico di rischio di sviluppo di un episodio di colite severa entro tre anni dalla diagnosi in una coorte italiana per la prima volta. METODI Disegno dello studio e pazienti: Il nostro è stato uno studio retrospettivo, caso-controllo, che ha incluso pazienti con colite ulcerosa diagnosticati a Roma, presso l’Università “Sapienza” tra il settembre del 2007 e il Settembre del 2010. RISULTATI Demografica dei pazienti 243 pazienti sono stati inclusi nello studio (median follow-up 46m, range 36-60). Su 243 pazienti inclusi nello studio, 88/243 (36%) sono stati ricoverati almeno una volta entro i tre anni dalla diagnosi con colite severa, mentre 155/243 (64%) non sono mai stati ricoverati. Alla regressione multivariata l’estensione di malattia, i livelli di PCR ed Hb e l’apparenza endoscopica risultavano tutti fattori di rischio significativamente diversi tra i due gruppi alla diagnosi di malattia. In particolare la pancolite e l’apparenza endoscopica severa risultavano piu frequenti alla diagnosi e la PCR e l’Hb si presentavano rispettivamente piu alta e piu bassa alla diagnosi nei pazienti che avrebbero sviluppato colite severa entro 3 anni. Il passo successivo, dal momento che le la variabile “apparenza endoscopica” anche se significativa è stata ottenuta senza l’utilizzo di uno score validato e standardizzato, e quindi riproducibile, è stato quello di escludere questa voce dall’analisi finale. Un modello predittivo semplificato è stato quindi individuato basato su 3 componenti: estensione della malattia, PCR, Hb alla diagnosi di colite ulcerosa
Guillain-Barrè syndrome after treatment with human anti-tumor necrosis factorα (adalimumab) in a Crohn's disease patient: case report and literature review
No full textThe central role of psychopathology and its association with disease severity in inflammatory bowel disease and irritable bowel syndrome
No full textBACKGROUND: Biopsychosocial models for both organic and functional gastrointestinal (GI) disorders can be found in the literature. To clarify the role of psychopathological factors and their relationship with GI symptom severity, several studies have examined them in inflammatory bowel disease (IBD) - occasionally distinguishing between ulcerative colitis (UC) and Crohn's disease (CD) - and in irritable bowel syndrome (IBS), leading to unclear results. AIMS: We aimed to evaluate the psychopathological features of IBD and IBS patients in comparison with healthy individuals and assess the association with disease severity. MATERIALS AND METHODS: Sixty-nine IBD outpatients, of which 35 UC and 34 CD, and 75 IBS ones were consecutively recruited at the third level Gastroenterological Center of our University Hospital; 76 healthy controls were also recruited. The psychological status was assessed with the Symptom Checklist-90-Revised (SCL-90-R). RESULTS: IBD and IBS patients showed significantly higher scores on the SCL-90-R Global Severity Index (GSI) and subscales than controls (all p-values<0.001), and IBS patients showed significantly higher GSI, depression, and anxiety scores than IBD patients (all p-values<0.01). Psychopathology was comparable between UC and CD patients. In IBD and IBS patients the SCL-90-R GSI was significantly associated with disease severity (p<0.001). CONCLUSIONS: The presence of chronic bowel symptoms, either organic or functional, is linked to a greater severity of psychopathology compared to the general population, possibly as a consequence of higher loads of stress due to the symptoms affecting everyday life. In both IBD and IBS patients, greater disease severity and worse psychopathological functioning are related
Postoperative recurrence of Crohn's disease and videocapsule endoscopy: It is necessary to leave no stone unturned.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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