80 research outputs found
Developing, Validating and Using Internal Ratings: Methodologies and Case Studies
No full textWith a focus on practical applications of biophysical techniques, Biophysical Methods for Biotherapeutics helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods. Author Tapan K. Das links fundamental biophysics to the process of biopharmaceutical development using a chapter organization according to the steps of the drug development process. The text provides information to help organizations develop short- and long-term strategies for resource investment in biophysical research. © 2010 John Wiley & Sons, Ltd
Secure document management and distribution in an open network environment
No full textThis paper analyzes the problem of secure document management and distribution in an open network environment. Reader and author authentication, document integrity, origin, and privacy are addressed by a public-key based solution which exploits a combination of the PEM format with SSL-enhanced FTP and HTTP servers and clients. The solution is being implemented as part of a project to provide network security to the Italian public administratio
Cross-sectional imaging after pancreatic surgery: The dialogue between the radiologist and the surgeon
No full textPancreatic surgery is nowadays considered one of the most complex surgical approaches and not unscathed from complications. After the surgical procedure, cross-sectional imaging is considered the non-invasive reference standard to detect early and late compilations, and consequently to address patients to the best management possible. Contras-enhanced computed tomography (CECT) should be considered the most important and useful imaging technique to evaluate the surgical site. Thanks to its speed, contrast, and spatial resolution, it can help reach the final diagnosis with high accuracy. On the other hand, magnetic resonance imaging (MRI) should be considered as a second-line imaging approach, especially for the evaluation of biliary findings and late complications. In both cases, the radiologist should be aware of protocols and what to look at, to create a robust dialogue with the surgeon and outline a fitted treatment for each patient
Conditions at risk of pancreatic cancer: The radiology perspective
No full text: Pancreatic cancer remains one for the most aggressive cancer worldwide, with pancreatic ductal adenocarcinoma being the most common malignant pancreatic lesion, associated with poor prognosis. While surgical resection is the only curative treatment, only a minority of patients is eligible for surgery due to its diagnosis at advanced stages. Therefore, strategies for early detection of pancreatic cancer are needed. This article aims to provide a state-of-the-art review of the most common conditions associated to an increased risk of pancreatic cancer. Conditions linked to risk of pancreatic cancer development include certain pancreato-biliary anatomical variants, intraductal papillary mucinous neoplasms, mucinous cystic neoplasm, and familial pancreatic cancer with specific genetic mutations. Early imaging signs of pancreatic cancer can also be incidentally encountered on CT or MRI performed for other indications and they should be promptly recognized by the radiologists in order to avoid delays in the diagnosis. The features include focal pancreatic atrophy, contour deformity, dilation of the main pancreatic duct (MPD), changes in the caliber of the MPD, abrupt interruption of the MPD, and biliary tree dilation. MRI with the adoption of abbreviated protocols has been increasingly evaluated for the follow-up of cystic lesions. Although screening of the general population is not recommended due to the low incidence and high costs, surveillance with MRI can be considered in selected high-risk individuals
Un viaggio culturale attraverso le mostre fotografiche: dalla wilderness di A. Adams al parco dei divertimenti di M. Pesaresi
No full textIn this essay photography is regarded as a tool for the careful observation of the landscape, which keeps the observer’s perception through places of everyday life as well as remote places, sometimes non directly experienced. In both instances images represent landscape knowledge and documentation caught in the instant of photography shot. According to his observational point, the author offers his own “sight”. Photographic exhibitions are here described as an opportunity for carefully understanding the landscape. They take the observer to a cultural journey in which his look is led by the author with thoroughness and method, transmitting “indefinable feelings”. Their poetry remains fluctuating in the memory of the spectator, creating new geographical frontiers, new meeting spaces and differences
Gli inizi di Felice Giani, ovvero l’incamminamento alla pittura di un giovane prodigioso
No full textIl testo ripercorre i momenti e gli esiti del percorso bolognese di Felice Giani, giunto nella città universitaria per frequentare l'Accademia Clementina di Pittura, Scultura e Architettura dell'Istituto delle Scienze, una tra le più prestigiose istituzioni artistiche dell'epoca. Nei soli due anni che trascorse a Bologna il giovane poté legarsi in amicizia con altri allievi di vaglia ed entrare in contatto con Serafino Barozzi, l'artista che lo introdurrà presso la nobiltà faentina che tanta importanza avrebbe avuto nel suo percorso, e soprattutto con i fratelli Gandolfi, Ubaldo e Gaetano, dalle cui scelte maniere apprese i termini per accrescere il suo stile. Fu a Bologna che imparò, grazie alla sperimentazione che l'abate Requeno conduceva presso la casa del conte Cesare Massimiliano Gini, la tecnica della pittura ad encausto, il che gli concesse di collaborare, una volta giunto a Roma, alla realizzazione della replica con il legante a cera delle pitture della Loggia di Raffaello del Vaticano per Caterina II di Russia. Due soli anni, dunque, ma fondamentali per la crescita di questo artista agile e spiritos
Holocene Deformations at the Po Plain–Southern Alps Transition (Lake Maggiore, Italy): Inferences on Glacially vs. Tectonic-Induced Origin
No full textThe investigation of deformations in Quaternary deposits holds primary importance in understanding recent geological history and natural hazards in highly populated areas, such as the Po Plain. While civil excavations and trenches possess the potential to be pivotal in identifying and characterizing these deformations, they often remain underused due to the stringent regulation framework and timetables governing civil construction works. In this study, we demonstrate how digital photogrammetry and digital outcrop modelling (DOM) are useful techniques for obtaining a permanent digital representation of a trench situated in Castelletto Ticino (Po Plain–Southern Alps transition). This trench exhibits Holocene deformational structures: (i) an overall tilting of sedimentary deposits towards the SW; (ii) folds with a NE–SW trend; (iii) slumping and other soft-sediment deformations structures; and (iv) reverse faults with NE–SW and NW–SE directions. Using radiocarbon and archeological dating, we are able to confidently constrain the age of these deformations to between 8760 and 400 years BC, suggesting recent tectonic activity related to buried thrust faults
L'alfabeto "Osmanìa" in Somalia
No full textL'autore riferisce sulle vicende dell'alfabeto osmania, dopo le notizie fornite su di esso dal Cerulli, e dà alcuni testi in questa scrittura.Qoraagu wuxuu ka hadlayaa taariikhda farta Cusmaaniya, kaddib markii laga helay warkeeda Cerulli, iyo qoraallo ku saabsan fartan.The author reports on the history of the "osmania" alphabet, after the earlier account by E. Cerulli, and gives some texts in this writing
Role of age at diagnosis in defining potential familial nonmedullary thyroid cancer in kindreds with two affected members
No full textContext
The definition of familial nonmedullary thyroid cancer (FNMTC) in 2 or more first-degree relatives is controversial due to the high probability of observing a sporadic association when only 2 members of first-degree relatives are affected.
Objective
To evaluate the role of age at diagnosis in differentiating the true cases of FNMTC.
Design, Setting, Participants, and Main Outcome
From a group of 721 papillary thyroid cancer (PTC) patients, 95 familial PTC (FPTC) patients with 2 first-degree relatives have been identified. They were split in 2 groups: Group 1 consisted of both the proband and the affected relative, with age at diagnosis ≤ 45 years; Group 2 consisted of proband and/or the affected family member, with age at diagnosis > 45 years. The clinical-pathological features and outcome of both FPTC groups were compared with 626 sporadic PTC patients (SPTC).
Results
Familial PTC patients with age at diagnosis ≤ 45 years, compared with the matched group of sporadic PTCs, had a more frequent multifocal, bilateral, and extrathyroidal extension of tumor and showed worse outcome. No differences were found between FPTC and SPTC patients with age > 45 years. At multivariate analysis, distant metastases, American Thyroid Association (ATA) risk, and FPTC ≤ 45 years were independent predictors of outcome.
Conclusions
Based on the observation that PTC is more aggressive when the diagnosis is made in 2 family members, both with age < 45years, we suggest that the definition of FPTC in kindreds with 2 affected members should also take into account the age at diagnosis as a key element of familial cancer.
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved
Environmental adjustment, academic involvement and difficulties of students with disabilities in ecuador
No full textThis study examines the state of education for disabled students in Ecuador, and includes
information obtained through interviews with select disabled undergraduate students. The author
provides recommendations for how educational institutions and individuals can better support
disabled students.El estudio examina el estado de la education para estudiantes descapacitados en Ecuador, e incluye informacion obtenida mediante entrevistas con ciertos estudiantes descapacitados a nivel universitario. El autor provee recomendaciones para que las instituciones academicas e individuos puedan apoyar mejor a estudiantes descapacitados
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