156 research outputs found
Optimisation of formulation processes for active pharmaceutical ingredients in porous polymeric carriers
No full textNamen magistrske naloge je bil optimizirati formulacijo polimernih nosilcev kot sistemov za dostavo farmacevtskih učinkovin. Cilj je bil izboljšati topnost izbranih farmacevtskih učinkovin ter doseči podaljšano sproščanje v simuliranih telesnih tekočinah. Polimerni nosilci so obetavni na področju razvoja sistemov s formuliranimi zdravili, saj lahko z ustrezno prilagoditvijo njihovih fizikalno-kemijskih lastnosti dosežemo izboljšano formuliranje in sproščanje farmacevtskih učinkovin.
V sklopu laboratorijskega dela smo sintetizirali plastovite polimerne nosilce, v katere smo uspešno formulirali dve različni farmacevtski učinkovini z različno polarnostjo. Izbrana polimera sta bila hitozan in alginat. S procesom superkritičnega penjenja smo izdelali tudi porozne polimerne nosilce, kjer smo kot začetni polimer uporabili polikaprolakton. Kot farmacevtski učinkovini smo izbrali ketoprofen in klindamicin hidroklorid. Izbrali smo ju glede na njuno topnost v telesnih tekočinah. Ketoprofen se uporablja za zdravljenje akutne bolečine in je slabo topen, medtem ko je klindamicin hidroklorid bolj topen v telesnih tekočinah in se uporablja kot antibiotik.
Karakterizacijo formuliranih polimernih nosilcev z vsebnostjo farmacevtskih učinkovin smo izvedli z vrstično elektronsko mikroskopijo in tehniko oslabljenega totalnega odboja infrardeče spektroskopije s Fourierjevo transformacijo. Z in vitro testiranjem sproščanja smo prikazali spreminjanje vsebnosti formuliranih farmacevtskih učinkovin v polimernih nosilcih glede na čas sproščanja, pridobljene vzorce smo analizirali s tekočinsko kromatografijo visoke ločljivosti in z UV-Vis spektrofotometrijo.
Rezultati so nedvoumno pokazali, da je formulacija farmacevtskih učinkovin v polimerne nosilce omogočila podaljšano sproščanje v telesnih tekočinah. Ugotovitve kažejo, da so porozni polimerni nosilci bolj primerni za sisteme dostave zdravil s podaljšanim sproščanjem v primerjavi s plastovitimi polimernimi nosilci.The aim of the master\u27s thesis was to prepare the optimized polymer-based formulation for drug delivery. The objective was to improve the solubility of selected drugs and to achieve their sustained release in simulated body fluids. Polymer-based carriers are promising for the development of drug delivery systems, as improved drug release can be achieved by appropriate tailoring of their physiochemical properties.
The experimental work involved the synthesis of layered polymeric carriers in which two drugs with different polarities were successfully formulated. The selected polymers for the preparation of layered carriers were chitosan and alginate. Porous polymeric carriers were also prepared by supercritical CO2-assisted foaming, using polycaprolactone as the starting polymer. Ketoprofen and clindamycin hydrochloride were selected based on their polarity and solubility in body fluids. Ketoprofen is anti-inflammatory drug used to treat acute pain and is poorly soluble in water-based media, while clindamycin hydrochloride is used as an antibiotic and is freely soluble in body fluids.
The characterization of the formulated drug-loaded polymeric carriers was carried out using Scanning Electron Microscopy and Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy. In vitro drug release tests were used to evaluate the percentage of the drugs released from polymer carriers as a function of time. The concentrations of released drugs were determined using High-Performance Liquid Chromatography and UV-Vis spectrophotometry.
The results showed that the formulation of drug-loaded polymeric carriers enabled prolonged drug release into simulated body fluids. In addition, it was shown that the porous polymeric carriers are better suited for sustained-release drug delivery systems compared to layered polymer carriers
The impact of storing kombucha starter culture on activation rate and quality of fermented beverage
No full textV diplomskem delu je opisana študija vpliva časa shranjevanja starter kulture kombuče na hitrost aktivacije in kakovost fermentiranega napitka. Prav tako prikazujemo vpliv temperature shranjevanja starter kulture na fermentacijo. Fermentacija je v obeh primerih trajala 14 dni. Med procesom smo spremljali pH vrednosti ter koncentracije sladkorjev in ogljikovega dioksida v fermentiranem napitku.
Za določitev koncentracij sladkorjev smo uporabljali sistem za tekočinsko kromatografijo visoke ločljivosti, za merjenje ogljikovega dioksida smo uporabljali ion selektivno elektrodo ter pH elektrodo za določitev pH vrednosti. Vsi vzorci so fermentirali v posodi z volumnom 1000 mL. Z meritvami in rezultati smo potrdili, da se koncentracije sladkorjev in pH vrednosti med fermentacijo znižujejo, koncentracija CO2 pa narašča. Prav tako smo ugotovili, da starejši starter rabi več časa za aktivacijo, vendar je kakovost fermentiranega napitka enaka, kot pri vzorcu s svežim starterjem. Rezultati kažejo, da višja temperatura shranjevanja starterja pospeši fermentacijo in nastanek simbiotične kulture.The thesis describes a study of the effects of the storage time of the kombucha starter culture on the activation rate and the quality of the fermented beverage. We also show the effect of the storage temperature of the starter culture on the fermentation. The fermentation lasted 14 days in both cases. During the process, we monitored the pH values and the concentrations of sugars and carbon dioxide in the fermented beverage.
A high-performance liquid chromatography system was used to determine the sugar concentrations, an ion-selective electrode was used to measure the carbon dioxide, and a pH electrode was used to determine the pH. All samples were fermented in a vessel with a volume of 1000 mL. The measurements and results confirmed that the sugar concentrations and pH decreased during fermentation, while the CO2 concentration increased. We also found that the older starter takes longer to activate, but the quality of the fermented beverage is the same as that of the sample with the fresh starter. The results show that a higher storage temperature of the starter accelerates the fermentation and the formation of a symbiotic culture
Biologically inspired modeling of vehicle to vehicle communication for intelligent transportation systems applications
No full textIn this study we developed a macroscopic model for simulating the vehicle to vehicle communication process. Real-time information propagation via vehicle-to-vehicle communication is part of the Vehicle Infrastructure Integration (VII) initiative, aimed at
improving the traffic conditions on existing roadways. In VII, Vehicles communicate among themselves using wireless technology. Each vehicle broadcasts any available information regarding the roadway (which might include time taken to travel a small stretch, any hazardous conditions, incidents etc) and other vehicles upstream, which might not be aware of the conditions ahead, receive the information. In this thesis, a
fraction of the vehicles traveling on the network are assumed to be equipped with the wireless technology and have the ability to communicate. These are called the “instrumented” vehicles. The proposed model is based on the Susceptible – Infected –Removed (SIR) model that is used to model the spread of epidemics in a region. We call the vehicles that have received a signal from another vehicle as ‘infected vehicles’, and
those instrumented vehicles that have not received a wireless message are called ‘susceptible vehicles’. The present model predicts the number of infected vehicles present on the roadway at every instant of time. The model is developed for a variety of traffic conditions including different volumes, speed limits and number of lanes. Finally, it is validated using simulation results obtained from Paramics, a microscopic traffic simulation software. Various observations related to the process of vehicle to vehicle communication were also made.M.S.Includes bibliographical referencesby Teja Indrakant
Libro de inventario de limosnas, donativos y venta de teja y madera
No full textLibro de inventario de limosnas, donativos y venta de teja y madera, 197
Synthesis of Carboxamide and Sulfonyl Carboxamide Linked Azoles Under Green Conditions
No full textDirect coupling of heteroaldehydes with heteroaryl amines/sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron-withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines. © 2020 Author(s).One of the authors G. Lakshmi Teja is indebted to the University Grants Commission (UGC), New Delhi for sanction of UGC-BSR fellowship
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Series 6: Audio Recordings
No full textSound recording of panelists at the Lone Star Sesquicentennial conference hosted by the University of Texas at Austin. First panelist: Robin Doughty, PhD; Second panelist: Frank de la Teja, PhD; Third panelist: Fane Downs, PhD; Moderator: T. R. Fehrenbach, author of the book "Lone Star", described as a historian who made Texas larger than life. Doughty gives a biographical account of an early pioneer frontierswoman; de la Teja discusses life in San Antonio in the 1820s; Downs discusses the role women played on the frontier, debunks the myths of the helpless heroine, the sturdy helpmate, and the bad woman. Side A starts in the middle of Doughty's presentation, and ends in the middle of Downs' presentation. Side B starts in the middle of a Q&A with the panelists
Faktor-Faktor yang Berhubungan dengan Kejadian Stunting Pada Balita di Kelurahan Tunjung Teja Kecamatan Tunjung Teja Kabupaten Serang Provinsi Banten
No full textABSTRACT According to data from the toddler cohort at 4 Posyandu, Tunjung Teja District for the period January 2024 to June 2024, it was recorded that of the 172 toddlers aged 6-59 months who regularly attended posyandu, there were 39 (22.6%) toddlers whose height was below -2SD or included in the category stunting. Therefore, the author is interested in knowing the factors related to the incidence of stunting among toddlers in Tunjung Teja Village, Tunjung Teja District, Serang Regency, Banten Province in 2024. To find out the factors related to the incidence of stunting in toddlers. This type of research is descriptive analytical, using a cross sectional research design, and using Chi Square test analysis, conducted in June 2024 with a population of 172 toddlers aged 6 months to 59 months, a sample of 120 toddlers with a simple random sampling technique, tools Data collection for the dependent variable is a microscopic measuring instrument, measuring Body Length (PB) and Body Height (TB) with an accuracy of 0.1 cm, independent variables using interview and documentation techniques. Univariate and Bivariate data analysis using the chi square statistical test. The results of the study showed that of the 120 respondents who experienced stunting, 63 were toddlers (52.5%), from the 4 variables studied, the results showed that there was a relationship between history of exclusive breastfeeding, a p-value of 0.012 and an Odd Ratio (OR) value of 0.363. 363 means toddlers who did not receive breast milk Exclusives have a 0.363 times chance of experiencing stunting compared to toddlers who receive exclusive breast milk. Infectious Diseases p-value 0.000 and OR 4.038 means that toddlers who have a history of infectious diseases have a 4.038 times chance of experiencing stunting compared to toddlers who do not have a history of infectious diseases. Immunization History Basic p-value of 0.001 and OR 0.202 means that toddlers who have never been immunized have a 0.202 chance of experiencing stunting compared to toddlers who have been immunized. Maternal Education p-value 0.020 and OR 2.560 means that mothers with low education have a 2.560 times chance of having stunted children compared to mothers with higher education. There is a relationship between the variables Exclusive Breastfeeding, Infectious Diseases, Complete Basic Immunization History, Mother's Education and the incidence of stunting in toddlers. This research suggests that mothers can provide exclusive breast milk, maintain children's health so they do not experience infectious diseases, and provide complete basic immunization. Keywords: Exclusive Breastfeeding, Infectious Diseases, Complete Basic Immunization History, Maternal Education, Stunting. ABSTRAK Menurut data kohort balita di 4 Posyandu Kelurahan Tunjung Teja periode Januari 2024 sampai Juni 2024, tercatat dari 172 balita berusia 6-59 bulan yang rutin mengikuti posyandu terdapat 39 (22,6%) balita yang tinggi badan nya di bawah -2SD atau termasuk kategori stunting. Oleh karena itu penulis tertarik untuk mengetahui faktor-faktor yang berhubungan dengan kejadian stunting pada balita di Kelurahan Tunjung Teja Kecamatan Tunjung Teja Kabupaten Serang Provinsi Banten Tahun 2024. Untuk mengetahui faktor-faktor yang berhubungan dengan kejadian stunting pada balita. Jenis Penelitian ini adalah deskriptif analitik, menggunakan design penelitian cross sectional, dan menggunakan analisis uji Chi Square, dilakukan pada bulan Juni 2024 dengan jumlah populasi 172 balita berusia 6 bulan sampai 59 bulan, sampel 120 balita dengan teknik pengambilan sampel secara simple random sampling, alat pengumpulan data variable dependen adalah alat ukur mikrotois, pengkuran Panjang Badan (PB) dan Tinggi Badan (TB) dengan ketelitian 0,1 cm, variable independen dengan teknik wawancara dan dokumentasi. Analisa data univariat dan Bivariat dengan uji statistic chi square. Hasil penelitian menunjukan dari 120 responden yang mengalami stunting sebanyak 63 Balita (52,5%), Dari 4 variabel yang diteliti didapatkan hasil ada hubungan Riwayat ASI Ekslusif p-value 0,012 dan nilai Odd Rasio (OR) 0,363 berarti balita yang tidak mendapatkan ASI ekslusif mempunyai peluang 0,363 kali mengalami stunting dibandingkan balita yang mendapatkan ASI ekslusif. Penyakit Infeksi p-value 0,000 dan OR 4,038 berarti balita yang mempunyai riwayat penyakit infeksi mempunyai peluang 4,038 kali mengalami stunting dibandingkan balita yang tidak mempunyai riwayat penyakit infeksi. Riwayat Imunisasi Dasar Lengkap p-value 0,001 dan OR 0,202 berarti Balita yang tidak pernah di imunisasi mempunyai peluang 0,202 kali mengalami stunting dibandingkan balita yang pernah di imunisasi. Pendidikan Ibu p-value 0,020 dan OR 2,560 berarti ibu dengan pendidikan rendah mempunyai peluang 2,560 kali mempunyai anak stunting dibandingkan ibu dengan pendidikan tinggi. Terdapat hubungan antara variabel ASI Ekslusif, Penyakit Infeksi Riwayat Imunisasi Dasar Lengkap, Pendidikan Ibu dengan kejadian stunting pada balita. Penelitian ini menyarankan agar ibu dapat memberikan ASi ekslusif, menjaga kesehatan anak agar tidak mengalami penyakit infeksi, memberikan imunisai dasar secara lengkap. Kata Kunci: ASI Ekslusif, Penyakit Infeksi, Riwayat Imunisasi Dasar Lengkap, Pendidikan Ibu, Stuntin
Plan de branding para el posicionamiento de teja toledo y el desarrollo del hábito de consumo de tejas metálicas en el mercado ecuatoriano
No full textEn la actualidad los índices de crecimiento de los diferentes sectores productivos del país no son para nada alentadores y hablan acertadamente de los problemas que nuestra economía hoy en día se encuentra afrontando debido a la falta de políticas de estado y planeamiento de estrategias económicas que aseguren un crecimiento sostenido. Uno de los sectores que rompe esta tendencia y se encuentra en auge de crecimiento es el sector de la construcción; aprovechando esta gran oportunidad, ROOFTEC Ecuador S.A., empresa del grupo ACESCO (Acerías de Colombia) especializada en la fabricación de paneles metálicos para cubiertas, cuyo producto de nuestro estudio se comercializa como TEJA TOLEDO, es la primera y única cubierta metálica en el país desde el año 2005. Desde sus inicios tuvo gran acogida en la zona de Azuay y Pichincha del país, mientras que en la zona guayas y sus zonas de influencia (Los Ríos, El oro y Sta. Elena) no se han obtenido los resultados en ventas proyectados.
El propósito fundamental del proyecto es posicionar a la marca Teja Toledo a nivel nacional y generar una recordación de la misma como una opción durable y estética, accesible al consumidor. En el plan operativo de branding se creará una identidad de marca basada en la asociación con la durabilidad y el diseño, y se desarrollarán estrategias de mercadeo en función de su posicionamiento. El resultado esperado será el incremento en ventas y la recordación de la marca al momento de construir una cas
Study of Phospholipid/Graphene interfaces and the effect of substrate curvature on lipid morphology and dynamics.
No full textPhospholipids are an important class of lipids which are widely used as model platforms to study biological processes and interactions. They have been known to form stable interfaces with solid substrates like graphene, and these interfaces have potential applications in bio-sensing and targeted drug-delivery. In this paper, we perform molecular dynamics simulations of graphene supported lipid monolayers to characterize lipid properties in such interfaces. We observed substantial differences in lipid properties like tail order-parameter, density profile, diffusion rate, etc., between lipids in a supported monolayer and free-standing bilayer. Further, we studied these interfaces on sinusoidally deformed graphene substrates to understand the effect of curvature on the supported lipids. Here, we observed that the nature of substrate curvature—concave, convex or flat—can affect the lipid/substrate adhesion strength as well as induce structural and dynamical changes in the adsorbed lipid monolayer. Together, these results help characterize the properties of lipid/graphene interfaces, as well as understand the effect of substrate curvature on these interfaces, which can enable tuning of lipid properties for various sensor device and drug delivery applications.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-08-01The student, Mohan Teja Dronadula, accepted the attached license on 2021-07-21 at 14:29.The student, Mohan Teja Dronadula, submitted this Thesis for approval on 2021-07-21 at 14:57.This Thesis was approved for publication on 2021-07-22 at 16:43.DSpace SAF Submission Ingestion Package generated from Vireo submission #17054 on 2022-01-12 at 13:05:30Made available in DSpace on 2022-01-12T22:56:15Z (GMT). No. of bitstreams: 3
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