1,721,105 research outputs found
Pietra di Langa. Continuità e discontinuità nelle culture costruttive e nel paesaggio
Full text linkLa pietra come ruolo storico e potenzialità di innovazione e costruzione nell'attenzione alle culture del territorio della Lang
Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.
No full textMedullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The RET proto-oncogene plays a key role in the development of MTC. However, one half of sporadic MTC do not carry RET mutations. Mice models and early evidence obtained in human samples suggest that other genes, including those encoding components of the RB (retinoblastoma) and TP53 tumour suppressor pathways, may be involved in MTC formation. Here we review the data on the involvement of genes acting in the RET and RB/TP53 pathways in MTC. Understanding genetic lesions that occur in MTC is a prerequisite to identifying molecular therapeutic targets in MTC and to improving the efficacy of RET-targeted therapies
Enhancing Neuropsychological Testing with Gamification and Tangible Interfaces: The Baking Tray Task
No full textNeuropsychological tests are performance-based tasks to evaluate cognitive functions, but often they are particularly long and boring during their execution; these issues can interfere with performance provided by patients or healthy participants. In this paper, we present our gamified and virtually enhanced version of a specific neuropsychological test: The Baking Tray Task (BTT), aimed to assess unilateral spatial neglect (USN), a visuospatial processing disorder. This enhanced BTT version has been developed through STELT (Smart Technologies to Enhance Learning and Teaching) software, a platform which allows implementation of augmented reality systems based on RFID/NFC technology. These materials permit to link together smart technologies and physical materials, uniting the manipulative approach and digitalized technologies
Using technology and tangible interfaces in a visuospatial cognition task: The case of the Baking Tray Task
No full textThe Baking Tray Task (BTT) is a neuropsychological test, aimed to assess unilateral spatial neglect (USN), a visuospatial disorder mainly associated to right parietal lobe damage. Over the years, the BTT has been re-proposed in different forms, other materials to be placed and in both digital and virtual environment preserving the initial settings and the way of administration. In this paper, we present two versions of BTT, the E-BTT and the BTT-SCAN, improved by technology. The aim of these tools is to present a new technological version of the same test in order to preserve a high validity and reliability and to acquire massive and more precise data
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
La lactancia materna y sus representaciones sociales: Un hecho natural, una experiencia privada, un fenomeno social
No full textEn esto capitulo presentamos los resultados de nuestra investigaciòn sobre las representaciones sociales de la lactancia. La parte introductoria es de tipo històrico y tiene la funciòn de mostrar còmo la pràctica de la lactancia a estado influida también en el pasado por factores sociales y culturales, que han determinado la influencia de las "modas" pasajeras. Posteriormente, se presentan los resultados de tres estudios realizados par nosotros, que tienen por denominador comùn una asunciòn bàsica: "? La representaciones sociales de la lactancia varìan segùn los sujetos estén màs o menos cercanos a este objeto? qué principios organizan sus representaciones? El hecho es pertinente si consideramos las representaciones sociales como principios reguladores de tomas de postura que diferencian a un sujeto de otro, y que se derivan de sus inserciones en un conjunto de relaciones sociales (Doise, 1990)
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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